DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Gprc5c

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_006247740.2	Gene:	Gprc5c / 287805	RGDID:	1311408	Length:	538	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	99/410 - (24%)
Similarity:	158/410 - (38%)	Gaps:	95/410 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 PGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELS 665
            ||..|..|.| .|.|..:...|..:...:..|..|....||.|::.......||......|.::.
  Rat   125 PGCSPDLDPL-YYNLCDRSGAWGIVLEAVAGAGIITTFVLTIILVASLPFVQDTKKRSLLGTQVF 188

  Fly   666 YTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKT---NRISRIFHSASKSA 727
            :  |.|.|..:|..||.:.||...:|..:||..||.|:|.:|.|:..|   |.::|..|
  Rat   189 F--LLGTLGLFCLVFACVVKPDFSTCASRRFLFGVLFAICFSCLIAHTLSLNFLARKNH------ 245

  Fly   728 QRLKYISPQSQVVITTSLI--AIQVLITMIWMV---------VEPPG------TRFYYPDRREVI 775
                  .|:..|:.|.:|:  .::|:|...|::         |..||      |         |.
  Rat   246 ------GPRGWVIFTVALLLTLVEVIINTEWLIITLVRGGGQVSTPGNGSADWT---------VT 295

  Fly   776 LKCKIQDMSFLFSQLYNMILI---------TICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWL 831
            ..|.|.:|.|:.:.:|.|:|:         |:|..:. :.||      ...|:..|..|:..||:
  Rat   296 SPCAIANMDFVMALIYVMLLLLAAFLGAWPTLCGRFK-RWRK------HGVFVLLTTATSIAIWV 353

  Fly   832 AFVPIYFGTGNSYEVQTT----TLCISISLSA----------SVALVCLYSP-KVYILVFHPDKN 881
            .::.:| ..||......|    ||.|:::.:|          .|:.|...|| :.|....:|.:.
  Rat   354 VWIVMY-TYGNKQHHSPTWDDPTLAIALAANAWTFVFFYVIPEVSQVTKPSPEQSYQGDMYPTRG 417

  Fly   882 V------RKLTMNSTVYRRSAAAVAQGA----PTS--SGY-----SRTHAPGTSALTGGAVGTNA 929
            |      ::.|..|......|.::.:.|    |.|  |||     :..:.|...||........|
  Rat   418 VGYETILKEQTGQSMFVENKAFSMDEPASAKRPVSPYSGYNGQLLTSVYQPTEMALMHKGPSEGA 482

  Fly   930 SSSTLP--TQNSPHLDEASA 947
            ....||  |.||..:..|::
  Rat   483 YDVILPRATANSQVMGSANS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141
		ANF_receptor	72..518	CDD:279440
		NCD3G	557..604	CDD:284890	2/2 (100%)
		7tm_3	638..873	CDD:278433	67/278 (24%)
Gprc5c	XP_006247740.2	7tmC_RAIG3_GPRC5C	144..401	CDD:320404	68/287 (24%)
		TM helix 1	145..169	CDD:320404	6/23 (26%)
		TM helix 2	183..204	CDD:320404	7/22 (32%)
		TM helix 3	213..235	CDD:320404	8/21 (38%)
		TM helix 4	254..270	CDD:320404	4/15 (27%)
		TM helix 5	301..324	CDD:320404	5/22 (23%)
		TM helix 6	338..360	CDD:320404	6/22 (27%)
		TM helix 7	370..395	CDD:320404	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910