DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vom2r27

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_775153.2	Gene:	Vom2r27 / 286914	RGDID:	708442	Length:	862	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	214/892 - (23%)
Similarity:	367/892 - (41%)	Gaps:	110/892 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVHEKGEGAPCGPKVY--NRGV--------------------QRLEAMLYAIDRVN 85
            |::::.|.||..          .||  |:.:                    |.:.||.:||:.:|
  Rat    38 GNVVIVGFFPAF----------AVYPLNKTIDWWMLKFSKEVMIEFKLKSYQYILAMRFAIEEIN 92

  Fly    86 NDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVF 150
            ::|::||..::|..|.:......|.|.:  .|...|.:|.|...|..|..|      |:::
  Rat    93 SNPHLLPNTSLGFEINNVPHGQRYTLVK--LFSSLSGSNYDIPNYISASES------NSAA---- 145

  Fly   151 GVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNF 215
             |:.|...::|..|..||.|:..||::.......||::.||....:..|.|||.:..:|.::.:|
  Rat   146 -VLTGPSWTISECVGTLLDLYKFPQLTFGPFDSLLSEQRRFSSLYQVAPKDTFLTPGIVSLMLHF 209

  Fly   216 NWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVP---SAADDKVFDSIISKLQKKPNAR 277
            :|::|.....:...|...:..|..|..:..||.|..|.:|   .:...|.:.:.:..|:...|.
  Rat   210 HWNWVGLFIIDDDKGAQTLSDLRNEMDKNGVCTAFVEMIPVIKGSFFTKSWKNHVQILESSSNV- 273

  Fly   278 GVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADF 342
             ::::..::....::...|:..|:... |:....|...:.....:.|...||:......|.|.:|
  Rat   274 -IIIYGDSDSLLSLIVNIKQKLLTWKV-WVLISQWDVSKFDDYFMVDSLHGALIFSHHREEIPNF 336

  Fly   343 DRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDN-KIGVKAKTECDDSYRL 406
            ..:|.:..|.....:.:....|...|||..    ||.|.....|...| .:|.......|
  Rat   337 TDFMQKYNPSKYPEDTYLHVLWHMYFNCSF----VKKDCKIVHNCLPNASLGFLPGNIFD----- 392

  Fly   407 SEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQ 471
               :...:||..  |.:||||.|   |:||....|....||.|..|.:    |::       ..|
  Rat   393 ---MAMSEESYN--VYNAVYAVA---HSLHEMILNQVQFQTHEKGKKM----VFF-------PWQ 438

  Fly   472 ACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKW 536
            ..|             :|.....|:..|:....|........|||||:.......|...|| |.:
  Rat   439 LHP-------------FLRERQLINQNGANEDLDCTRKSHVEYDILNFWNFPKGLGLNVKV-GTF 489

  Fly   537 F------NGLQLNSETVVW-NKETEQPTSACSLPCEVGMIKKQQGD--TCCWICDSCESFEY--V 590
            .      ..|.::|..:.| ...||.|.|.||..|..|..|..|..  .||:.|..|...|.  .
  Rat   490 SPSAPKEQKLSISSNMIQWATGSTEIPQSVCSESCHPGFRKTHQEGRVACCFDCIPCPENEISNE 554

  Fly   591 YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTP 655
            .|...|..|....:...:|:.|....:.::.::.........:::...:||:.|:|:|.||.|||
  Rat   555 TDVDQCVKCPETHYANIEKIHCLQKTVTFLYYDDPLGKTLCFMSLGFSSLTAAVLVVFLKNRDTP 619

  Fly   656 LVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIF 720
            :|:|:...||||||..:::|:......|.:|:..||:||:...|:.|::..|.:|.||..:...|
  Rat   620 IVKANNLALSYTLLITLMLCFLCPLLFIGRPSTASCILQQNIFGLLFTVALSTVLAKTITVVIAF 684

  Fly   721 HSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPG-TRFYYPDRREVILKC-KIQDM 783
            ...|....|...:..::...|......:||.::.||:...||. .:..:.:...:|:.| |...:
  Rat   685 KITSPGRIRRWLLISRAPNFIIPLCTLLQVFLSGIWLTTSPPFIDKDAHSEHGHIIIICNKGSAV 749

  Fly   784 SFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQT 848
            :|..:..|...|..:....|..:|.:|:.|||:||:.|:|...|.:|:.|:|:|..|.....|..
  Rat   750 AFHCNLGYLGALALVSYFMAFLSRNLPDTFNEAKFLAFSMLVFCSVWVTFLPVYHSTKGKNMVAM 814

  Fly   849 TTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRS 895
            ..  .||..|::..|..:::||.|:::..|::|......:.| |.:|
  Rat   815 EV--FSILASSTSLLGIIFAPKCYLILLRPERNSLSYIRDKT-YAKS 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	116/530 (22%)
		ANF_receptor	72..518	CDD:279440	102/449 (23%)
		NCD3G	557..604	CDD:284890	15/50 (30%)
		7tm_3	638..873	CDD:278433	70/236 (30%)
Vom2r27	NP_775153.2	PBP1_pheromone_receptor	41..508	CDD:380588	116/534 (22%)
		7tmC_V2R_pheromone	589..840	CDD:320410	71/252 (28%)
		TM helix 1	590..614	CDD:320410	5/23 (22%)
		TM helix 2	626..647	CDD:320410	7/20 (35%)
		TM helix 3	656..678	CDD:320410	7/21 (33%)
		TM helix 4	704..720	CDD:320410	3/15 (20%)
		TM helix 5	747..770	CDD:320410	3/22 (14%)
		TM helix 6	782..804	CDD:320410	8/21 (38%)
		TM helix 7	809..834	CDD:320410	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910