Protein Alignment mGluR and Grm4

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001277974.1
• Gene: Grm4 / 268934
• MGIID: 1351341
• Length: 912
• Species: Mus musculus
• Alignment Length: 933
• Identity: 415/933 - (44%)
• Similarity: 571/933 - (61%)
• Gaps: 79/933 - (8%)

  Fly    38 SVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHIL 101
            |:.:.|||.||||||||.:| ||..||.....:|:.||||||:|:||:||||::||.||:|..||
Mouse    42 SIRIDGDITLGGLFPVHGRGSEGKACGELKKEKGIHRLEAMLFALDRINNDPDLLPNITLGARIL 106

  Fly   102 DTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVAN 166
            |||||||:||.|||.||:|.:.. |.:...|..|..|.:.|...   |.||||.|.||||:.|||
Mouse   107 DTCSRDTHALEQSLTFVQALIEK-DGTEVRCGSGGPPIITKPER---VVGVIGASGSSVSIMVAN 167

  Fly   167 LLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGE 231
            :||||.|||:|.||||..|||.:|:|.|:|.||.||:|:.|:|||::...|:||||:.|||||||
Mouse   168 ILRLFKIPQISYASTAPDLSDNSRYDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTLASEGSYGE 232

  Fly   232 YGIEALHKEATER-NVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAA 295
            .|:||..:::.|. .||||.:.|:|.......||.||.:|.:..|||.:::|...:|.||:|:||
Mouse   233 SGVEAFIQKSRENGGVCIAQSVKIPREPKTGEFDKIIKRLLETSNARAIIIFANEDDIRRVLEAA 297

  Fly   296 KRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWF 360
            :|||.:..|.|:.||.||.:...:..||::||||:|:..:...:..||||....|.:.|:||.||
Mouse   298 RRANQTGHFFWMGSDSWGSKSAPVLRLEEVAEGAVTILPKRTSVRGFDRYFSSRTLDNNRRNIWF 362

  Fly   361 AEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAV 425
            ||:|||.|:|.|:..::|.             |...| :|.:..|:.:...||||.|.|||:|||
Mouse   363 AEFWEDNFHCKLSRHALKK-------------GSHIK-KCTNRERIGQDSAYEQEGKVQFVIDAV 413

  Fly   426 YAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLL 490
            ||..:|||.:|.|.|                          ..:...||.|...||.:.. .|:.
Mouse   414 YAMGHALHAMHRDLC--------------------------PGRVGLCPRMDPVDGTQLL-KYIR 451

  Fly   491 NVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQ 555
            ||:|..:||:.|.|:..||...||||..|||:..|:  :|||||.|.:.|.|..|.:.|....:|
Mouse   452 NVNFSGIAGNPVTFNENGDAPGRYDIYQYQRRNGSA--EYKVIGSWTDHLHLRIERMQWPGSGQQ 514

  Fly   556 -PTSACSLPCEVGMIKKQ-QGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQ 618
             |.|.|||||:.|..||. :|..|||.|:.|..::|..|.:|||.|...:.|..::.||..:.|.
Mouse   515 LPRSICSLPCQPGERKKTVKGMACCWHCEPCTGYQYQVDRYTCKTCPYDMRPTENRTSCQPIPIV 579

  Fly   619 YMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALI 683
            .::|:|.:|::|:.:|:.|||.|..|:|.|.:.:|||:|:||||||||.||.||.:||..||.:|
Mouse   580 KLEWDSPWAVLPLFLAVVGIAATLFVVVTFVRYNDTPIVKASGRELSYVLLAGIFLCYATTFLMI 644

  Fly   684 AKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAI 748
            |:|.:|:|.|:|..:|:|.||.|:|||||||||.|||....:|....::|||.||:.||..||::
Mouse   645 AEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIFEQGKRSVSAPRFISPASQLAITFVLISL 709

  Fly   749 QVLITMIWMVVEPPGTRFYYPDRREV-------ILKCKIQDMSFLFSQLYNMILITICTIYAIKT 806
            |:|...:|.||:|..:...:.|:|.:       :|||.|.|:|.:....|:|:|:..||:|||||
Mouse   710 QLLGICVWFVVDPSHSVVDFQDQRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKT 774

  Fly   807 RKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYE---VQTTTLCISISLSASVALVCLYS 868
            |.:||.|||:|.||||||||||:||||:||:|||..|.:   :|||||.:|:||||||:|..||.
Mouse   775 RGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYM 839

  Fly   869 PKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSST 933
            |||||::|||::||.|       .:||..||...|..|:.:::   .|.....|     .|.|..
Mouse   840 PKVYIILFHPEQNVPK-------RKRSLKAVVTAATMSNKFTQ---KGNFRPNG-----EAKSEL 889

  Fly   934 LPTQNSPHLDEASAQTNVAHKTN 956
            .....:|.|  |:.||.|.: ||
Mouse   890 CENLEAPAL--ATKQTYVTY-TN 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	223/504 (44%)
		NCD3G	556..605	CDD:462210	22/49 (45%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	135/260 (52%)
		TM helix 1	625..650	CDD:320600	10/24 (42%)
		TM helix 2	662..683	CDD:320600	13/20 (65%)
		TM helix 3	692..716	CDD:320600	14/23 (61%)
		TM helix 4	738..758	CDD:320600	8/19 (42%)
		TM helix 5	781..807	CDD:320600	11/25 (44%)
		TM helix 6	815..838	CDD:320600	18/22 (82%)
		TM helix 7	845..870	CDD:320600	15/27 (56%)
Grm4	NP_001277974.1	PBP1_mGluR_groupIII	43..508	CDD:380599	225/511 (44%)
		NCD3G	516..566	CDD:462210	22/49 (45%)
		7tmC_mGluR4	586..912	CDD:320568	159/342 (46%)
		TM helix 1	586..611	CDD:320568	10/24 (42%)
		TM helix 2	623..644	CDD:320568	13/20 (65%)
		TM helix 3	653..677	CDD:320568	14/23 (61%)
		TM helix 4	699..719	CDD:320568	8/19 (42%)
		TM helix 5	749..775	CDD:320568	11/25 (44%)
		TM helix 6	783..806	CDD:320568	18/22 (82%)
		TM helix 7	816..841	CDD:320568	15/24 (63%)