Protein Alignment mGluR and Casr

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_058692.1
• Gene: Casr / 24247
• RGDID: 2277
• Length: 1079
• Species: Rattus norvegicus
• Alignment Length: 971
• Identity: 289/971 - (29%)
• Similarity: 478/971 - (49%)
• Gaps: 101/971 - (10%)

  Fly    12 VVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVH-----------EKGEGAPCGPK 65
            :.::.|:|.        |:.:..|. .....||||||||||:|           .:.|...|  .
  Rat     8 LALLALAWH--------SSAYGPDQ-RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC--I 61

  Fly    66 VYN-RGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSG 129
            .|| ||.:.|:||::||:.:|:.|::||.:|:|..|.|||:..:.||..:|.||  :.|.:|:..
  Rat    62 RYNFRGFRWLQAMIFAIEEINSSPSLLPNMTLGYRIFDTCNTVSKALEATLSFV--AQNKIDSLN 124

  Fly   130 YE----CADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTR 190
            .:    |::.....:          .|:|.:.|.||..|||||.||:|||||.||:::.||:|.:
  Rat   125 LDEFCNCSEHIPSTI----------AVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179

  Fly   191 FDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVP 255
            :..|.||:|.|..|:.|:.||::.|.|::|.||.::..||..|||...:||.||::||..:|.:.
  Rat   180 YKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELIS 244

  Fly   256 SAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKL-L 319
            ..:|::....::..:|.. .|:.:|:|:...|...:::...|.|::... |:||:.|.....: :
  Rat   245 QYSDEEEIQQVVEVIQNS-TAKVIVVFSSGPDLEPLIKEIVRRNITGRI-WLASEAWASSSLIAM 307

  Fly   320 EGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKP---DT 381
            .....:..|.|...|::..|..|..::.::.|..:..|.:..|:||:||||.|...:..|   ||
  Rat   308 PEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHLQEGAKGPLPVDT 372

  Fly   382 SNSANSTDNKIGVKAKTE----C--DDSYRLSEK--VGYEQESKTQFVVDAVYAFAYALHNLHND 438
            ...::.......:.:.|.    |  |::....|.  :.||....:..|..|||:.|:||.:::.
  Rat   373 FVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNVYLAVYSIAHALQDIYT- 436

  Fly   439 RCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVK 503
             |             |....::        .:.:|.|:...:..:.. .:|.:::|.:..|.:|.
  Rat   437 -C-------------LPGRGLF--------TNGSCADIKKVEAWQVL-KHLRHLNFTNNMGEQVT 478

  Fly   504 FDRQGDGLARYDILNYQ-RQENSS------GYQYKVIGKWFNGLQLNSETVVWNK-ETEQPTSAC 560
            ||..||.:..|.|:|:. ..|:.|      || |.|..|....|.:|.|.::|:. ..|.|.|.|
  Rat   479 FDECGDLVGNYSIINWHLSPEDGSIVFKEVGY-YNVYAKKGERLFINEEKILWSGFSREVPFSNC 542

  Fly   561 SLPCEVGMIKK-QQGD-TCCWICDSCESFEY--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMK 621
            |..|:.|..|. .:|: |||:.|..|...||  ..|...|..|....|...:..||.|.:|:::.
  Rat   543 SRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIAKEIEFLA 607

  Fly   622 WNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKP 686
            |...|.:.....|:.||.||:.|:.:|.|..:||:|:|:.|||||.|||.:|.|:.::...|.:|
  Rat   608 WTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEP 672

  Fly   687 TIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVL 751
            ...:|.|::...|:.|.:..|.:|.||||:..:|.:...::...|:.....|.::......:|:|
  Rat   673 QDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIL 737

  Fly   752 ITMIWMVVEPPGTRFYYPDRREVI-LKCKIQDMSFLFSQL-YNMILITICTIYAIKTRKIPENFN 814
            |.:||:...||.:...:....|:| :.|....:..|.|.: |..:|..||..:|.|:||:|||||
  Rat   738 ICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYTCLLAAICFFFAFKSRKLPENFN 802

  Fly   815 ESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFHP 878
            |:|||.|:|....|:|::|:|.|..|...:......:.|   |:||..|: |::..||||::|.|
  Rat   803 EAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAI---LAASFGLLACIFFNKVYIILFKP 864

  Fly   879 DKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNS 939
            .:|..:...:||.......| |:........||..    |:..||:.|:..|||.....||
  Rat   865 SRNTIEEVRSSTAAHAFKVA-ARATLRRPNISRKR----SSSLGGSTGSIPSSSISSKSNS 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	154/537 (29%)
		NCD3G	556..605	CDD:462210	18/52 (35%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	85/253 (34%)
		TM helix 1	625..650	CDD:320600	8/24 (33%)
		TM helix 2	662..683	CDD:320600	10/20 (50%)
		TM helix 3	692..716	CDD:320600	8/23 (35%)
		TM helix 4	738..758	CDD:320600	6/19 (32%)
		TM helix 5	781..807	CDD:320600	8/26 (31%)
		TM helix 6	815..838	CDD:320600	10/22 (45%)
		TM helix 7	845..870	CDD:320600	6/25 (24%)
Casr	NP_058692.1	Ligand-binding 1 (LB1). /evidence=ECO:0000250|UniProtKB:P41180	22..188		66/180 (37%)
		PBP1_CaSR	33..530	CDD:380587	153/537 (28%)
		Ligand-binding 2 (LB2). /evidence=ECO:0000250|UniProtKB:P41180	189..324		37/136 (27%)
		NCD3G	538..591	CDD:462210	18/52 (35%)
		Cysteine-rich (CR). /evidence=ECO:0000250|UniProtKB:P41180	542..612		22/69 (32%)
		7tmC_CaSR	611..862	CDD:320409	85/253 (34%)
		TM helix 1	611..636	CDD:320409	8/24 (33%)
		Intracellular loop 1 (ICL1). /evidence=ECO:0000250|UniProtKB:P41180	637..648		4/10 (40%)
		TM helix 2	648..669	CDD:320409	10/20 (50%)
		TM helix 3	678..702	CDD:320409	8/23 (35%)
		Intracellular loop 2 (ICL2). /evidence=ECO:0000250|UniProtKB:P41180	699..722		5/22 (23%)
		TM helix 4	726..742	CDD:320409	3/15 (20%)
		TM helix 5	769..795	CDD:320409	8/25 (32%)
		Intracellular loop 3 (ICL3). /evidence=ECO:0000250|UniProtKB:P41180	790..805		10/14 (71%)
		TM helix 6	803..826	CDD:320409	10/22 (45%)
		TM helix 7	831..856	CDD:320409	6/27 (22%)
		C-terminus. /evidence=ECO:0000250|UniProtKB:P41180	855..1079		22/71 (31%)
		Interaction with RNF19A. /evidence=ECO:0000250|UniProtKB:P41180	880..900		4/24 (17%)
		Arginine-rich retention motif. /evidence=ECO:0000250|UniProtKB:P41180	890..898		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	894..964		11/31 (35%)