Protein Alignment mGluR and Vmn2r104

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001098036.1
• Gene: Vmn2r104 / 22313
• MGIID: 1316665
• Length: 860
• Species: Mus musculus
• Alignment Length: 896
• Identity: 216/896 - (24%)
• Similarity: 367/896 - (40%)
• Gaps: 137/896 - (15%)

  Fly    44 DIILGGLFPVH----EKGEGAPCGPKVY--------NRGVQRLEAMLYAIDRVNNDPNILPGITI 96
            |:::|..||:|    ||.:.....|.||        .:..|.:.|:|:||:.:|.:|||||.|::
Mouse    43 DVMIGAFFPLHTLYTEKKKPHSTKPYVYLDYYIQYNFKNYQYILALLFAIEEINRNPNILPNISL 107

  Fly    97 GVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVS 161
            |....:....:...|..:.:::.|.:.......|.|.       |:|     |...:.||....|
Mouse   108 GFDFYNNEYTERNILRFTCRWLTAHVKRAMIPNYTCK-------RRN-----VIAALTGSSWITS 160

  Fly   162 LQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSE 226
            .|:..||:||..||::......||||..::....:..|.||..|:|:|..:.:|:||::..|..:
Mouse   161 AQIGTLLQLFKFPQITFGPYEPTLSDDGQYSSLYQMAPKDTSLSLAIVSFMVHFSWSWIGLIIPD 225

  Fly   227 GSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRI 291
            ...|...:....:|.....:|||..:.:|:     .:.|..::..:..:...|::.....|:..|
Mouse   226 NHKGNKILSEFREEMERNKICIAFLKMIPA-----TWTSYFTRFWENMDETNVIIIYGDIDSLEI 285

  Fly   292 LQAAKRANLSQPFHWIASDGWGKQQKLLE----GLEDIAEGAITVELQSEIIADFDRYMMQLTPE 352
            |.......|.....||.::    :..::|    .:.|...|:...........:|.:::.::.|.
Mouse   286 LMQIIGQRLLTWNIWIMNN----EPHIIELSDYFMLDSFHGSFIFRHNYRDNIEFTKFIQRVNPY 346

  Fly   353 TNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESK 417
            ....:.:..:.|...|.|..:.:        :.:..||   .|.....|........|...:||.
Mouse   347 KYPEDIYLPKLWNFFFKCSFSDI--------NCHVLDN---CKTNASLDLLPSFIFDVVMSEEST 400

  Fly   418 TQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYR-KISTDTKSQACPDMANYDG 481
            .  :.:.|||.|::||.:.......|:.:..|       |.|::. :::|..|.....|..|.|.
Mouse   401 N--IYNGVYALAHSLHQMRLQLLQMQAFENGE-------EMVFFPWQLNTFLKDIEVKDKRNLDW 456

  Fly   482 KEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNG-----LQ 541
            |:          .||               ..|||||........|.:.|:.....|.     |.
Mouse   457 KQ----------TID---------------TEYDILNLWNLPKGLGLKVKIGSFSANAPQGQQLS 496

  Fly   542 LNSETVVWNK-ETEQPTSACSLPCEVGMIKKQQGD--TCCWICDSCESFEY--VYDEFTCKDCGP 601
            |:.:.:.|.: .:|.|.|.||..|..|..|....|  .||:.|..|...|.  ..|...|..|..
Mouse   497 LSEQIIQWPEIFSEVPQSVCSESCRPGFRKVSLDDKAICCYKCTPCADNEISNETDVDQCVKCPE 561

  Fly   602 GLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSY 666
            ..:...:|.:|:...:.::.:.....:...:||:...|||..||.:|.||.|||:|:|:.|.|||
Mouse   562 SHYANTEKSNCFPKSVSFLAYEDPLGMALASIALCLSALTVFVIGIFVKNRDTPIVKANNRTLSY 626

  Fly   667 TLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLK 731
            .||..:..|:..:...|.:|...:|:||:....|.|::..:.:|.|...:...| ..|...:.|:
Mouse   627 ILLITLTFCFLCSLNFIGQPNTAACILQQTTFAVAFTMALATVLAKAITVVLAF-KISFPGRMLR 690

  Fly   732 YI----SPQSQVVITTSLIAIQVLITMIWMVVEPP------GTRFYYPDRREVILKCK------- 779
            ::    .|:..:.|.|   .||:|:..|||...||      .|...|     :||.|.
Mouse   691 WLMISRGPRYIIPICT---LIQLLLCGIWMATSPPFIDQDVNTEDGY-----IILLCNKGSAVAF 747

  Fly   780 ---IQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTG 841
               :..:.||....|.|         |..:|.:|:.||||||:.|:|.....:|:.|:|:|..|.
Mouse   748 HSVLGYLCFLALGSYTM---------AFLSRNLPDTFNESKFLSFSMLVFFCVWVTFLPVYHSTK 803

  Fly   842 NSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKN----VRKLTMN 888
            .  :|.......||..|::..|..::.||.||::..|:||    :||.|.:
Mouse   804 G--KVMVAMEVFSILASSTALLAFIFGPKCYIILLRPEKNSFNHIRKKTQS 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	110/519 (21%)
		NCD3G	556..605	CDD:462210	16/52 (31%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	79/270 (29%)
		TM helix 1	625..650	CDD:320600	8/24 (33%)
		TM helix 2	662..683	CDD:320600	7/20 (35%)
		TM helix 3	692..716	CDD:320600	6/23 (26%)
		TM helix 4	738..758	CDD:320600	7/19 (37%)
		TM helix 5	781..807	CDD:320600	5/25 (20%)
		TM helix 6	815..838	CDD:320600	9/22 (41%)
		TM helix 7	845..870	CDD:320600	5/24 (21%)
Vmn2r104	NP_001098036.1	PBP1_pheromone_receptor	45..504	CDD:380588	110/524 (21%)
		NCD3G	512..565	CDD:462210	16/52 (31%)
		7tmC_V2R_pheromone	585..836	CDD:320410	79/270 (29%)
		TM helix 1	585..610	CDD:320410	8/24 (33%)
		TM helix 2	622..643	CDD:320410	7/20 (35%)
		TM helix 3	652..676	CDD:320410	6/23 (26%)
		TM helix 4	700..716	CDD:320410	5/18 (28%)
		TM helix 5	743..769	CDD:320410	5/34 (15%)
		TM helix 6	777..800	CDD:320410	9/22 (41%)
		TM helix 7	805..830	CDD:320410	5/24 (21%)