Protein Alignment mGluR and Vmn2r107

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001098039.1
• Gene: Vmn2r107 / 22312
• MGIID: 1316664
• Length: 861
• Species: Mus musculus
• Alignment Length: 893
• Identity: 208/893 - (23%)
• Similarity: 380/893 - (42%)
• Gaps: 148/893 - (16%)

  Fly    43 GDIILGGLFPVH----EKGEGAPCGPKVYNRG--------VQRLEAMLYAIDRVNNDPNILPGIT 95
            ||:::|..||||    ||.......|..|..|        .|.:.|:|:||:.:|.:||:||.|:
Mouse    40 GDVMIGAFFPVHTFYTEKKRPHSTIPYQYLDGYIQYNFKNYQYILALLFAIEEINGNPNLLPNIS 104

  Fly    96 IGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSV 160
            :|....:....:...|..::.::.|.:.......|.|.       :.|.::     .|.|:....
Mouse   105 LGFDFYNVRFTEKETLMNTVIWLTAHVQRKVLPNYNCK-------KSNFTA-----AITGTSWIT 157

  Fly   161 SLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHS 225
            |.|:..||:||..||::.......|||:.::....:..|.||..|:|:|.::.:|.||:|..|..
Mouse   158 SAQIGTLLQLFKFPQITFGPYDPFLSDRGQYPSLYQMAPKDTSLSLAIVSLMVHFRWSWVGLILP 222

  Fly   226 EGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARR 290
            :...|...:....||...:.:|.|..:.:|:     .:.|...|..:..:...:::.....|:
Mouse   223 DDHKGNKILSDFRKEMERKRICTAFVKMIPA-----TWTSSFVKFWENMDDTNIIIIYGDIDS-- 280

  Fly   291 ILQAAKRANLSQ---PFH-WIASDGWGKQQKLLE----GLEDIAEGAITVELQSEIIADFDRYMM 347
             |:...| |:.|   .:| |:.:    .:..::|    .:.|...|::..:.......:|.:::.
Mouse   281 -LEGLMR-NIGQRLLTWHVWVMN----IEPHIIEYDNYFMLDSFHGSLIFKHNYRENFEFTKFIR 339

  Fly   348 QLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGY 412
            .:.|:....:.:..:.|...|.|..:.::.:...|...|::.:.:    .::..|       |..
Mouse   340 TVNPKKYPEDIYLPKMWYLFFMCSFSDINCQVLDSCQTNASLDML----PSQIFD-------VVM 393

  Fly   413 EQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMA 477
            .:||.:  :.:||||.|::||.:...:..||..:
Mouse   394 SEESTS--IYNAVYAVAHSLHEMRLQQLQTQPCE------------------------------- 425

  Fly   478 NYDGKEFY----NNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFN 538
            |.:|.||:    |.:|.:   |::..:.:.:.::.|  |.|||||........|.:.|:...:.|
Mouse   426 NEEGMEFFPWQLNTFLKD---IEVRVNSLDWRQRID--AEYDILNLWNLPKGLGLKVKIGNFYAN 485

  Fly   539 G-----LQLNSETVVWNK-ETEQPTSACSLPCEVGM--IKKQQGDTCCWICDSCESFEY--VYDE 593
            .     |.|:.:.:.|.: .:|.|.|.||..|..|.  :..:....||:.|..|...|.  ..|.
Mouse   486 APQGQQLSLSEQMIQWPEIFSEIPQSVCSESCGPGFRKVTLENKAICCYNCTPCADNEISNETDV 550

  Fly   594 FTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVR 658
            ..|..|....:...:|.:||...:.::.:.....:...:||:...|||:.||.:|.|:.|||:|:
Mouse   551 DQCVKCPESHYANTEKSNCYQKSVSFLGYEDPLGMALASIALCLSALTAFVIGIFVKHKDTPIVK 615

  Fly   659 ASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSA 723
            |:.:.||||||..:..|:..:...|.:|...:|:||:....|.|::..:.:|.|...:...| ..
Mouse   616 ANNQALSYTLLITLKFCFLCSLNFIGQPNTVACILQQTTFAVAFTMALATVLAKAITVVLAF-KV 679

  Fly   724 SKSAQRLKYI----SPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDR------REVILKC 778
            |...:.::::    .|...:.|.|   .||:|:..|||.:.||     |.|:      ..:|:.|
Mouse   680 SFPGRMVRWLMISRGPNYIIPICT---LIQLLLCGIWMAISPP-----YIDQDAHIEHGHIIILC 736

  Fly   779 K----------IQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAF 833
            .          :..:.||....|.|         |..:|.:|:.|||||||..:|.....:|:.|
Mouse   737 NKGSAVAFHSVLGYLCFLALGSYTM---------AFLSRNLPDTFNESKFISLSMLVFFCVWITF 792

  Fly   834 VPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKN 881
            :|:|..|..  :|.......||..|::..|..::.||.||::..|:||
Mouse   793 LPVYHSTKG--KVMVAMEVFSILASSTALLAFIFGPKCYIILLRPEKN 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	109/527 (21%)
		NCD3G	556..605	CDD:462210	14/52 (27%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	76/270 (28%)
		TM helix 1	625..650	CDD:320600	8/24 (33%)
		TM helix 2	662..683	CDD:320600	7/20 (35%)
		TM helix 3	692..716	CDD:320600	6/23 (26%)
		TM helix 4	738..758	CDD:320600	7/19 (37%)
		TM helix 5	781..807	CDD:320600	5/25 (20%)
		TM helix 6	815..838	CDD:320600	9/22 (41%)
		TM helix 7	845..870	CDD:320600	5/24 (21%)
Vmn2r107	NP_001098039.1	PBP1_pheromone_receptor	43..501	CDD:380588	108/531 (20%)
		NCD3G	509..562	CDD:462210	14/52 (27%)
		7tmC_V2R_pheromone	582..833	CDD:320410	76/270 (28%)
		TM helix 1	582..607	CDD:320410	8/24 (33%)
		TM helix 2	619..640	CDD:320410	7/20 (35%)
		TM helix 3	649..673	CDD:320410	6/23 (26%)
		TM helix 4	697..713	CDD:320410	5/18 (28%)
		TM helix 5	740..766	CDD:320410	5/34 (15%)
		TM helix 6	774..797	CDD:320410	9/22 (41%)
		TM helix 7	802..827	CDD:320410	5/24 (21%)