DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and GPRC6A

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_683766.2	Gene:	GPRC6A / 222545	HGNCID:	18510	Length:	926	Species:	Homo sapiens

Alignment Length:	972	Identity:	253/972 - (26%)
Similarity:	422/972 - (43%)	Gaps:	140/972 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEK---GEGAPCGPKV------- 66
            :::::..:..::....|..| ..|.|:.:.||.||:||||.:|||   .|.:|..|::
Human     4 LIILITCFVIILATSQPCQT-PDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVGFE 67

  Fly    67 YNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYE 131
            .:..:|.| ||:::|:.:||. .:|||:.:|..|.|||:..|.|:..:|:|:.....:.:|..::
Human    68 ISVFLQTL-AMIHSIEMINNS-TLLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSRETVEFK 130

  Fly   132 CADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFAR 196
            | |.||...|..|       |||..||.:::.|:.:|.|..:|||...|||:.||||.||..|.|
Human   131 C-DYSSYMPRVKA-------VIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDKIRFPSFLR 187

  Fly   197 TVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDK 261
            |||.|..|..|:..:::...|:::..|.::..||...:.....:|...|||||..|.:|:...|.
Human   188 TVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFIIQAEANNVCIAFKEVLPAFLSDN 252

  Fly   262 VFDSIISKLQKK----PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKL--LE 320
            ..:..|::..||    .....:|:|.|......:...|...|:::  .|||||.|....|:  :.
Human   253 TIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK--MWIASDNWSTATKITTIP 315

  Fly   321 GLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSA 385
            .::.|.: .:....:...|:.|..::..|....:..:....||......|....     ||..|.
Human   316 NVKKIGK-VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLHEYAMHLSACAYVK-----DTDLSQ 374

  Fly   386 ---NSTDNKIGVKAKTECDDSYRLSEKV--GYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSD 445
               |.:...:..||....:.::.:....  .|.:......:..||:|..||:.:|    |..:..
Human   375 CIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSIQLAVFALGYAIRDL----CQARDC 435

  Fly   446 QTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDG 510
            |.....:..:...|                             |.||:|.| ..:...||..||.
Human   436 QNPNAFQPWELLGV-----------------------------LKNVTFTD-GWNSFHFDAHGDL 470

  Fly   511 LARYDILNYQRQENSSGYQYKVIGKWFNG-----------LQLNSETVVWNKET-------EQPT 557
            ...||:               |:.|..||           || |...::.::||       :|..
Human   471 NTGYDV---------------VLWKEINGHMTVTKMAEYDLQ-NDVFIIPDQETKNEFRNLKQIQ 519

  Fly   558 SACSLPCEVGMIKK--QQGDTCCWICDSCESFEYV--YDEFTCKDCGPGL-WPYADKLSCYALDI 617
            |.||..|..|.:||  :....||:.|.:|....|.  .|...|..|.... |.......|:..::
Human   520 SKCSKECSPGQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEV 584

  Fly   618 QYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFA- 681
            :|:.||...|::.:.:::.||....:|.::|.:|.:||:|::||   ...:.:.||:|:...||
Human   585 EYLNWNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSG---GLRVCYVILLCHFLNFAS 646

  Fly   682 ---LIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITT 743
               .|.:|...:|..::...||.|::..|.:|||:.:|...|....|..:.||.:.....::.|.
Human   647 TSFFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPKLQKFLKCLYRPILIIFTC 711

  Fly   744 SLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQL-YNMILITICTIYAIKTR 807
            :  .|||:|..:|::...|.........|.:||:|:...:....:.| |..||..||.|:|.|.:
Human   712 T--GIQVVICTLWLIFAAPTVEVNVSLPRVIILECEEGSILAFGTMLGYIAILAFICFIFAFKGK 774

  Fly   808 KIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVY 872
            .  ||:||:|||.|.|....|.|:.|:|||..|...|......:.|.||...  .|.|.:.||.|
Human   775 Y--ENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEIIVILISNYG--ILYCTFIPKCY 835

  Fly   873 ILVFHPDKNVRKLTMNSTVYRRSAAAVAQGA--PTSSGYSRTHAPGTSALTGGAVGTNASSS 932
            :::...:.|.:...: ..:|..|:.:|:..|  |.|          ..:::|....||.|||
Human   836 VIICKQEINTKSAFL-KMIYSYSSHSVSSIALSPAS----------LDSMSGNVTMTNPSSS 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	134/530 (25%)
		ANF_receptor	72..518	CDD:279440	116/456 (25%)
		NCD3G	557..604	CDD:284890	15/51 (29%)
		7tm_3	638..873	CDD:278433	73/239 (31%)
GPRC6A	NP_683766.2	PBP1_GPC6A_like	37..506	CDD:107356	134/536 (25%)
		ANF_receptor	75..482	CDD:279440	117/473 (25%)
		NCD3G	519..571	CDD:284890	15/51 (29%)
		7tm_3	607..836	CDD:278433	72/237 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910