DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mGluR and mgl-1

DIOPT Version :9

Sequence 1:NP_001259076.1 Gene:mGluR / 43838 FlyBaseID:FBgn0019985 Length:976 Species:Drosophila melanogaster
Sequence 2:NP_001300387.1 Gene:mgl-1 / 191707 WormBaseID:WBGene00003232 Length:952 Species:Caenorhabditis elegans


Alignment Length:963 Identity:396/963 - (41%)
Similarity:563/963 - (58%) Gaps:109/963 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 VVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGA--PCGPKVYNRGVQRLE 75
            |.:|...:..|||..|....     .:.:||||::||:||||.|....  |||.....|||.|:|
 Worm    29 VNVVAQTTEAVDLAPPPKVR-----QIRIPGDILIGGVFPVHSKSLNGDEPCGEIAETRGVHRVE 88

  Fly    76 AMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQL 140
            |||||:|::|:..:.|.|..:|..|||:||...|||||||.|||..:.:.:.|.|.|.|||.|.|
 Worm    89 AMLYALDQINSQNDFLRGYKLGALILDSCSNPAYALNQSLDFVRDMIGSSEASDYVCLDGSDPNL 153

  Fly   141 RKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQS 205
            :|.:....|..|:||||||||:|:|||||||.|.|||||||...||||.||:.||||||.|.:|:
 Worm   154 KKQSQKKNVAAVVGGSYSSVSVQLANLLRLFRIAQVSPASTNADLSDKNRFEYFARTVPSDDYQA 218

  Fly   206 VALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADD--KVFDSIIS 268
            :|:|:|...|.|||||.::|...|||.|.:|..|||.::.:|||:.|::.:..:.  :..::::.
 Worm   219 MAMVEIAVKFKWSYVSLVYSADEYGELGADAFKKEARKKGICIALEERIQNKKESFTESINNLVQ 283

  Fly   269 KLQKKPN--ARGVVLFTRAEDARRILQ-AAKRANLS----QPFHWIASDGWGK-QQKLLEGLEDI 325
            |||.:.|  |..||||...|....||: .|:|..|:    :...|:||:.|.: ..|...|...:
 Worm   284 KLQPEKNVGATVVVLFVGTEYIPDILRYTAERMKLTSGAKKRIIWLASESWDRNNDKYTAGDNRL 348

  Fly   326 -AEGAITVELQSEIIADFDRYMMQLTPETN--QRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANS 387
             |:|||.:.|.|:.:..|:.|.|.|.|.|.  :||.|..|.|:..:.|...:    |..|.::..
 Worm   349 AAQGAIVLMLASQKVPSFEEYFMSLHPGTEAFERNKWLRELWQVKYKCEFDT----PPGSTASRC 409

  Fly   388 TDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRK 452
            .|    :|..||           |:..:.|.|||:|||||.|:.|.::....|   .|...|.. 
 Worm   410 ED----IKQSTE-----------GFNADDKVQFVIDAVYAIAHGLQSMKQAIC---PDDAIENH- 455

  Fly   453 HLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDIL 517
                   |..:.|  .:.:.|..|.|.||.:||.||||.|:|.|:.|...:|..||||.|.|.||
 Worm   456 -------WISRYS--KQPEICHAMQNIDGSDFYQNYLLKVNFTDIVGKRFRFSPQGDGPASYTIL 511

  Fly   518 NYQ----------RQENSSGYQYKVIGKWF-NGLQLNSETVVWNKETEQPTSACSLPCEVG---- 567
            .|:          ..:.||...|..||.|. |.|.:..:.:.|:.: ..|.|.|||||::|    
 Worm   512 TYKPKSMDKKRRMTDDESSPSDYVEIGHWSENNLTIYEKNLWWDPD-HTPVSVCSLPCKIGFRKQ 575

  Fly   568 MIKKQQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYAL---DIQYMKWNSLFALI 629
            :||.:|   |||.|..||.:||:.:|..|..|..|.||..|:..|:.|   .::||:|.|:::|:
 Worm   576 LIKDEQ---CCWACSKCEDYEYLINETHCVGCEQGWWPTKDRKGCFDLSLSQLKYMRWRSMYSLV 637

  Fly   630 PMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQ 694
            |..:|:|||..|..|||::...::||:|:||||||||.||..:::|||.||.|::||:...|.::
 Worm   638 PTILAVFGIIATLFVIVVYVIYNETPVVKASGRELSYILLISMIMCYCMTFVLLSKPSAIVCAIK 702

  Fly   695 RFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVV 759
            |.|||..||.:|||:..|||||.|||  :::||||.::|||.||||:|..|..:|::.::||:.|
 Worm   703 RTGIGFAFSCLYSAMFVKTNRIFRIF--STRSAQRPRFISPISQVVMTAMLAGVQLIGSLIWLSV 765

  Fly   760 EPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMY 824
            .|||.|.:||.|.:|:|.|.:.|..||:|..|:..||.:||.||:||||:||||||:|||||:||
 Worm   766 VPPGWRHHYPTRDQVVLTCNVPDHHFLYSLAYDGFLIVLCTTYAVKTRKVPENFNETKFIGFSMY 830

  Fly   825 TTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRK----- 884
            |||::||:::..:||||:.:::||::||||||:||:|||.|::|||::|::|...|||||     
 Worm   831 TTCVVWLSWIFFFFGTGSDFQIQTSSLCISISMSANVALACIFSPKLWIILFEKHKNVRKQEGES 895

  Fly   885 ---------------LTMNS-------------TVYRRSAAAVAQGAPTSSGY 909
                           |..||             :..|||:...:|...|||.:
 Worm   896 MLNKSSRSLGNCSSRLCANSIDEPNQYTALLTDSTRRRSSRKTSQPTSTSSAH 948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mGluRNP_001259076.1 Periplasmic_Binding_Protein_Type_1 43..542 CDD:299141 209/524 (40%)
ANF_receptor 72..518 CDD:279440 183/458 (40%)
NCD3G 557..604 CDD:284890 22/50 (44%)
7tm_3 638..873 CDD:278433 125/234 (53%)
mgl-1NP_001300387.1 PBP1_mGluR 54..547 CDD:380585 209/524 (40%)
NCD3G 560..610 CDD:369426 23/52 (44%)
7tmC_mGluRs_group2_3 633..882 CDD:320600 131/250 (52%)
TM helix 1 634..658 CDD:320600 10/23 (43%)
TM helix 2 670..691 CDD:320600 12/20 (60%)
TM helix 3 700..722 CDD:320600 10/21 (48%)
TM helix 4 746..762 CDD:320600 4/15 (27%)
TM helix 5 787..810 CDD:320600 10/22 (45%)
TM helix 6 819..844 CDD:320600 15/24 (63%)
TM helix 7 851..876 CDD:320600 15/24 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159044
Domainoid 1 1.000 298 1.000 Domainoid score I781
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H651
Inparanoid 1 1.050 703 1.000 Inparanoid score I342
Isobase 1 0.950 - 0 Normalized mean entropy S3570
OMA 1 1.010 - - QHG49358
OrthoDB 1 1.010 - - D1154468at2759
OrthoFinder 1 1.000 - - FOG0003689
OrthoInspector 1 1.000 - - oto17657
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR24060
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2555
SonicParanoid 1 1.000 - - X509
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.990

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