DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and mgl-2

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_492720.3	Gene:	mgl-2 / 172914	WormBaseID:	WBGene00003233	Length:	1035	Species:	Caenorhabditis elegans

Alignment Length:	986	Identity:	330/986 - (33%)
Similarity:	530/986 - (53%)	Gaps:	108/986 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVVMVLSWSRVVDLKSPSNTHTQDSVSV---SLPGDIILGGLFPVHEKGEGA-PCGPKVYNRGVQ 72
            |.:::|   ||||:  .:.|..|.|..:   .:.|:|.:|.|||:|.:..|: .||......|:|
Worm     6 VTLLML---RVVDV--VAKTTVQQSARMLVAEIHGEIQIGALFPIHRQIAGSESCGEIWEQYGIQ 65

  Fly    73 RLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSS 137
            |.|..:..:.::|.:   || ..:|:.|.|:|..:..|:.|::.|:|..:       .:|:...:
Worm    66 RSEIAMLTVKQLNEE---LP-FKLGLSIRDSCWTERIAMEQTIAFLREGV-------AQCSCCQT 119

  Fly   138 PQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDT 202
            |..  |..|.||..|||...||.::.|.|||::|.||||..::|...||||.:|..|.|.||.|.
Worm   120 PGC--NKKSVPVVAVIGPGKSSSTIAVQNLLQVFRIPQVGYSATTPDLSDKEQFGYFLRVVPSDV 182

  Fly   203 FQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER--NVCIAVAEKVPSAADDKVFDS 265
            ||:.|:..:|.::||:||:.::|.|:|||.|.|:|.|....|  :||||.:||:.:.|.::.:..
Worm   183 FQAQAINRLLHHYNWTYVAVLYSAGNYGEKGFESLEKLIAHRSSSVCIAYSEKIKTLASEQEYRQ 247

  Fly   266 IISKLQKKPNARG--VVLFTRAEDARRILQAAKRANLS------QPFHWIASDGWGKQQKLLEGL 322
            ::::|..: |:|.  ||.|......|...:|.|  :|:      :.|.||.||||..:..::|.|
Worm   248 VLTRLDSQ-NSRPQVVVCFCEGASMRMFFKAQK--HLADGKMQMKRFQWIGSDGWADRNDVVEDL 309

  Fly   323 EDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANS 387
            |:.|||:.::.:.:..|..|.:|...|.||.|..||||.|:|:..|||   ..:|..:..|:.|
Worm   310 EEEAEGSFSIRIHAPKIPGFRQYYTALHPENNTMNPWFREFWQQKFNC---QFAVSKEDKNNEN- 370

  Fly   388 TDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRK 452
                |.:     |.....|.|:  |:::.|...|::::...|..|..::.|||.   |.:|
Worm   371 ----IRI-----CSGDENLDEQ--YKEDPKLSQVINSIRVVALGLKAMYQDRCR---DNST---- 417

  Fly   453 HLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDIL 517
                               .|.:|.:.:|...| .|||||::.|.....|.|||.||..|.||||
Worm   418 -------------------LCTEMLSRNGTLLY-EYLLNVTYSDQFKQPVYFDRNGDPPAWYDIL 462

  Fly   518 NY------QRQENSSGYQYKVIGKW-FNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQGD 575
            ||      ....|..| .:|.|..: ...|.:.::::.::|....|.|.||.||.:|. ::::..
Worm   463 NYIGTKDLDNPYNEVG-SFKSINDYGVEELDMTAKSMFFDKTELLPESVCSRPCGIGQ-RQRETM 525

  Fly   576 TCCWICDSCESFEYVYDEFT--CKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGI 638
            .|||||:||...:|| ::.|  |.:|..|.||.|::..|..:..:.:.|.|...::.:.:|:.||
Worm   526 ACCWICESCLDIQYV-NKTTNQCMNCTLGSWPNANRTGCEYIIPEVVSWTSFGHILALVLAVTGI 589

  Fly   639 ALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFS 703
            ..:...:.:|.:::.||:|:::.|||||.:|.|::.||..:|||:|.|:..||.:.|....:.|:
Worm   590 ITSMATLAVFLRHNSTPVVKSTTRELSYIILSGLVACYAVSFALLATPSTTSCFITRVIPPIAFA 654

  Fly   704 IIYSALLTKTNRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVE-PPGTR 765
            ::|||||||||||:||...:.|.  .::.::::..||||||..|:|:|.:|..:.::.: |..|.
Worm   655 VVYSALLTKTNRIARILAGSKKRILTKKPRFLTTFSQVVITWILVAVQCVIVGVGLMRDWPDATY 719

  Fly   766 FYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIW 830
            ..|...|::||:|..:..|||....::..|||:||:||.|||.:||||||:||||||||.|.::|
Worm   720 AKYALPRKLILECDTETKSFLIPFFWDFFLITLCTLYAFKTRNLPENFNEAKFIGFTMYCTVVVW 784

  Fly   831 LAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYR-- 893
            :||:.::.||.:    :...:..|.||||||||..|:.||:||::.||:||:|.....:.:.|
Worm   785 IAFLVLHMGTTH----KALVMSFSYSLSASVALALLFFPKLYIILMHPEKNIRASYTTTKLIRCH 845

  Fly   894 --RSAAAVAQ-------GAPTSSGYS-RTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQ 948
              .|.||...       |:.|::..| ::.:...|:..||.|...||.....::.|.|..:.|.|
Worm   846 FGNSQAAYDSTSKQQHLGSKTTARTSVQSGSASKSSSMGGGVTRTASVHVPVSRGSTHSTDVSTQ 910

  Fly   949 TNVAHKTNGEF 959
            |..|.|.:..|
Worm   911 TEAASKFSRSF 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	165/516 (32%)
		ANF_receptor	72..518	CDD:279440	146/455 (32%)
		NCD3G	557..604	CDD:284890	19/48 (40%)
		7tm_3	638..873	CDD:278433	99/237 (42%)
mgl-2	NP_492720.3	Periplasmic_Binding_Protein_type1	28..482	CDD:385651	162/512 (32%)
		NCD3G	507..556	CDD:369426	20/50 (40%)
		7tmC_mGluR_group1	576..826	CDD:320412	103/253 (41%)
		TM helix 1	577..601	CDD:320412	4/23 (17%)
		TM helix 2	613..634	CDD:320412	11/20 (55%)
		TM helix 3	643..665	CDD:320412	9/21 (43%)
		TM helix 4	693..709	CDD:320412	7/15 (47%)
		TM helix 5	735..758	CDD:320412	9/22 (41%)
		TM helix 6	767..792	CDD:320412	15/24 (63%)
		TM helix 7	795..820	CDD:320412	10/28 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810