DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Tas1r3

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_570831.1	Gene:	Tas1r3 / 170634	RGDID:	620539	Length:	858	Species:	Rattus norvegicus

Alignment Length:	936	Identity:	239/936 - (25%)
Similarity:	375/936 - (40%)	Gaps:	175/936 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVHEKGE----------GAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIG 97
            ||.|||||||:....|          |..| .:....|:....||..|::.:||...:|||:.:|
  Rat    33 GDYILGGLFPLGTTEEATLNQRTQPNGILC-TRFSPLGLFLAMAMKMAVEEINNGSALLPGLRLG 96

  Fly    98 VHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSL 162
            ..:.||||.....:..||.|: |.:.:...:.|.......|:         |..|||...|.::|
  Rat    97 YDLFDTCSEPVVTMKPSLMFM-AKVGSQSIAAYCNYTQYQPR---------VLAVIGPHSSELAL 151

  Fly   163 QVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEG 227
            ........|.:||||.:::...|||:..|..|.||||.|..|..|:|.:|:||:|::|:.:.|:.
  Rat   152 ITGKFFSFFLMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQNFSWNWVAALGSDD 216

  Fly   228 SYGEYGIEALHKEATERNVCIAVAEKVPSAADD-----KVFDSIISKLQKKPNARGVVLFTRAED 287
            .||..|:......|..|.:|||....||.....     ||.|.:....|.|  .:.||||..|..
  Rat   217 DYGREGLSIFSGLANSRGICIAHEGLVPQHDTSGQQLGKVVDVLRQVNQSK--VQVVVLFASARA 279

  Fly   288 ARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAE-GAITVELQSEIIADFDRYMMQLTP 351
            ...:...:...:|| |..|:||:.| ....|:..|.:||. |.:...||..          .|.|
  Rat   280 VYSLFSYSILHDLS-PKVWVASESW-LTSDLVMTLPNIARVGTVLGFLQRG----------ALLP 332

  Fly   352 ETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQES 416
            |       |:.|.|       |.|::..|.:..|:         .|.|.|    |.|:|...:.|
  Rat   333 E-------FSHYVE-------TRLALAADPTFCAS---------LKAELD----LEERVMGPRCS 370

  Fly   417 KTQFVV-------------------------DAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQS 456
            :..:::                         .|||:.|.||||  ..:||.....|:|..:..|.
  Rat   371 QCDYIMLQNLSSGLMQNLSAGQLHHQIFATYAAVYSVAQALHN--TLQCNVSHCHTSEPVQPWQL 433

  Fly   457 ESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSF--IDLAGSEVKFDRQGDGLARYDILNY 519
            ....|                             |:||  .||.   ::||.:|.....||:..:
  Rat   434 LENMY-----------------------------NMSFRARDLT---LQFDAKGSVDMEYDLKMW 466

  Fly   520 QRQENSSGYQYKVIGKWFNG-LQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQG-DTCCWICD 582
            ..|  |.......:|. ||| |||....:.| ...:.|.|.||..|:.|.:::.:| .:||:.|.
  Rat   467 VWQ--SPTPVLHTVGT-FNGTLQLQHSKMYW-PGNQVPVSQCSRQCKDGQVRRVKGFHSCCYDCV 527

  Fly   583 SCESFEYVY--DEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVI 645
            .|::..|..  |:|||..||...|......:|.....:::.|.....|..:.:....:.||...:
  Rat   528 DCKAGSYRKHPDDFTCTPCGKDQWSPEKSTTCLPRRPKFLAWGEPAVLSLLLLLCLVLGLTLAAL 592

  Fly   646 VLFAKNHDTPLVRASGRELSYTLLFGILVC---YCNTFALI-AKPTIGSCVLQRFGIGVGFSIIY 706
            .||....|:|||:|||..|   ..|| |:|   :|.:..|. .:|...||:.|:          .
  Rat   593 GLFVHYWDSPLVQASGGSL---FCFG-LICLGLFCLSVLLFPGRPRSASCLAQQ----------P 643

  Fly   707 SALLTKTNRISRIFHSAS----KSAQRLKYIS--------PQSQVVITTSLIAIQVLITMIWMVV 759
            .|.|..|..:|.:|..|:    :|...|.:.:        |.:.:|:..:.:....|.....|..
  Rat   644 MAHLPLTGCLSTLFLQAAEIFVESELPLSWANWLCSYLRGPWAWLVVLLATLVEAALCAWYLMAF 708

  Fly   760 EPPGTRFYYPDRREVILKCKIQD-MSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTM 823
            .|.....:.....||:..|:::. :|.....:.|.:|..:|.:.....:..|..:|.::.:.|.|
  Rat   709 PPEVVTDWQVLPTEVLEHCRMRSWVSLGLVHITNAVLAFLCFLGTFLVQSQPGRYNRARGLTFAM 773

  Fly   824 YTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMN 888
            ....|||::|||:......:|  |......:|...|...|...:.||.|:|::.|:.|.::..:.
  Rat   774 LAYFIIWVSFVPLLANVQVAY--QPAVQMGAILFCALGILATFHLPKCYVLLWLPELNTQEFFLG 836

  Fly   889 STVYRRSAAAVAQGAPTSSGYSRTHA 914
                 ||....:.|...||..:|.|:
  Rat   837 -----RSPKEASDGNSGSSEATRGHS 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	144/542 (27%)
		ANF_receptor	72..518	CDD:279440	124/478 (26%)
		NCD3G	557..604	CDD:284890	17/49 (35%)
		7tm_3	638..873	CDD:278433	59/251 (24%)
Tas1r3	NP_570831.1	Periplasmic_Binding_Protein_Type_1	29..494	CDD:299141	146/549 (27%)
		ANF_receptor	73..469	CDD:279440	124/480 (26%)
		NCD3G	501..551	CDD:284890	17/49 (35%)
		7tm_3	595..821	CDD:278433	56/241 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	839..858		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000