DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Grm1

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_058672.1	Gene:	Grm1 / 14816	MGIID:	1351338	Length:	1199	Species:	Mus musculus

Alignment Length:	945	Identity:	364/945 - (38%)
Similarity:	541/945 - (57%)	Gaps:	79/945 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TQDSVSVSLPGDIILGGLFPVH-----EKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILP 92
            :|.||: .:.||:|:|.||.||     ||.....||......|:||:|||.:.:|::|.||.:||
Mouse    34 SQRSVA-RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLP 97

  Fly    93 GITIGVHILDTCSRDTYALNQSLQFVRASLNNL--DTSGY-EC-ADGSSPQLRKNASSGPVFGVI 153
            .||:|..|.|:|...:.||.||::|:|.||.::  :..|. .| .||.:  |....:..|:.|||
Mouse    98 NITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGLNRCLPDGQT--LPPGRTKKPIAGVI 160

  Fly   154 GGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWS 218
            |...|||::||.|||:||.|||::.::|:..|||||.:..|.|.||.||.|:.|::||:|.:||:
Mouse   161 GPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWT 225

  Fly   219 YVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKK-PNARGVVLF 282
            |||.:|:||:|||.|::|..:.|.:..:|||.::|:.|.|.:|.||.::.||::: |.||.||.|
Mouse   226 YVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCF 290

  Fly   283 TRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMM 347
            ......|.:|.|.:|..:...|..|.||||..:.:::||.|..|.|.||::|||..:..||.|.:
Mouse   291 CEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFL 355

  Fly   348 QLTPETNQRNPWFAEYWEDTFNCVLTS-LSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVG 411
            :|..:||.|||||.|:|:..|.|.|.. |...|:               .|..|..:..|.|  .
Mouse   356 KLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPN---------------FKKVCTGNESLEE--N 403

  Fly   412 YEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDM 476
            |.|:||..||::|:||.|:.|.|:|:..|.....                          .|..|
Mouse   404 YVQDSKMGFVINAIYAMAHGLQNMHHALCPGYVG--------------------------LCDAM 442

  Fly   477 ANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNG-L 540
            ...||::.. ::|:..||:.::|.||.||.:||...||||:|.|..| ::.|.|..:|.|..| |
Mouse   443 KPIDGRKLL-DFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTE-ANRYDYVHVGTWHEGVL 505

  Fly   541 QLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGD-TCCWICDSCESFEYVYDEFTCKDCGPGL 603
            .::...:..|| :....|.||.||..|.||. ::|: :|||||.:|:..|:|.|||||:.|..|.
Mouse   506 NIDDYKIQMNK-SGMVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEFVQDEFTCRACDLGW 569

  Fly   604 WPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTL 668
            ||.|:...|..:.|:|::|:.:.::|.:|.:..||.:|..|.::|....|||:|::|.|||.|.:
Mouse   570 WPNAELTGCEPITIRYLEWSDIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYII 634

  Fly   669 LFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKS--AQRLK 731
            |.||.:.|...|.||||||..||.|||..:|:..::.||||:||||||:||...:.|.  .::.:
Mouse   635 LAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPR 699

  Fly   732 YISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILI 796
            ::|..:||:|.:.||::|:.:.:..:::|||.....||..:||.|.|...::..:....||.:||
Mouse   700 FMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPVGYNGLLI 764

  Fly   797 TICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASV 861
            ..||.||.|||.:|.||||:|:|.||||||||||||||||||  |::|::.||  |.::|||.:|
Mouse   765 MSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--GSNYKIITT--CFAVSLSVTV 825

  Fly   862 ALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQG-----APTSSGYSRTHAPGTSALT 921
            ||.|:::||:||::..|::|||.....|.|.|..   |..|     :.|.....|...||  |..
Mouse   826 ALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMH---VGDGKLPCRSNTFLNIFRRKKPG--AGN 885

  Fly   922 GGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTN 956
            ..:.|.:.|.|....:.:|.......:.:|..|||
Mouse   886 ANSNGKSVSWSEPGGRQAPKGQHVWQRLSVHVKTN 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	192/510 (38%)
		ANF_receptor	72..518	CDD:279440	170/451 (38%)
		NCD3G	557..604	CDD:284890	24/48 (50%)
		7tm_3	638..873	CDD:278433	109/236 (46%)
Grm1	NP_058672.1	PBP1_mGluR_groupI	36..510	CDD:380597	194/521 (37%)
		Glutamate binding. /evidence=ECO:0000250	186..188		0/1 (0%)
		NCD3G	521..571	CDD:400103	24/49 (49%)
		7tmC_mGluR1	591..840	CDD:320565	114/252 (45%)
		TM helix 1	592..616	CDD:320565	7/23 (30%)
		TM helix 2	628..649	CDD:320565	9/20 (45%)
		TM helix 3	658..680	CDD:320565	10/21 (48%)
		TM helix 4	708..724	CDD:320565	4/15 (27%)
		TM helix 5	749..772	CDD:320565	7/22 (32%)
		TM helix 6	784..806	CDD:320565	18/21 (86%)
		TM helix 7	809..834	CDD:320565	11/26 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..906		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	959..1035
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1055..1082
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1177
		GluR_Homer-bdg	1150..1199	CDD:402304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820