DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mGluR and Casr

DIOPT Version :9

Sequence 1:NP_001259076.1 Gene:mGluR / 43838 FlyBaseID:FBgn0019985 Length:976 Species:Drosophila melanogaster
Sequence 2:NP_038831.2 Gene:Casr / 12374 MGIID:1351351 Length:1079 Species:Mus musculus


Alignment Length:971 Identity:288/971 - (29%)
Similarity:476/971 - (49%) Gaps:101/971 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 VVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVH-----------EKGEGAPCGPK 65
            :.::.|:|.        |:.:..|. .....||||||||||:|           .:.|...|  .
Mouse     8 LALLALTWH--------SSAYGPDQ-RAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC--I 61

  Fly    66 VYN-RGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSG 129
            .|| ||.:.|:||::||:.:|:.|.:||.:|:|..|.|||:..:.||..:|.||  :.|.:|:..
Mouse    62 RYNFRGFRWLQAMIFAIEEINSSPALLPNMTLGYRIFDTCNTVSKALEATLSFV--AQNKIDSLN 124

  Fly   130 YE----CADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTR 190
            .:    |::.....:          .|:|.:.|.||..|||||.||:|||||.||:::.||:|.:
Mouse   125 LDEFCNCSEHIPSTI----------AVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQ 179

  Fly   191 FDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVP 255
            |..|.||:|.|..|:.|:.||::.|.|::|.||.::..||..|||...:||.||::||..:|.:.
Mouse   180 FKSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFSELIS 244

  Fly   256 SAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKL-L 319
            ..:|::....::..:|.. .|:.:|:|:...|...:::...|.|::... |:||:.|.....: :
Mouse   245 QYSDEEEIQQVVEVIQNS-TAKVIVVFSSGPDLEPLIKEIVRRNITGRI-WLASEAWASSSLIAM 307

  Fly   320 EGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKP---DT 381
            .....:..|.|...|::..|..|..::.::.|..:..|.:..|:||:||||.|...:..|   ||
Mouse   308 PEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHLQDGAKGPLPVDT 372

  Fly   382 SNSANSTDNKIGVKAKTE----C--DDSYRLSEK--VGYEQESKTQFVVDAVYAFAYALHNLHND 438
            ...::.......:.:.|.    |  |::....|.  :.||....:..|..|||:.|:||.:::. 
Mouse   373 FVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNVYLAVYSIAHALQDIYT- 436

  Fly   439 RCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVK 503
             |             |....::        .:.:|.|:...:..:.. .:|.:::|.:..|.:|.
Mouse   437 -C-------------LPGRGLF--------TNGSCADIKKVEAWQVL-KHLRHLNFTNNMGEQVT 478

  Fly   504 FDRQGDGLARYDILNYQ-RQENSS------GYQYKVIGKWFNGLQLNSETVVWNK-ETEQPTSAC 560
            ||..||.:..|.|:|:. ..|:.|      || |.|..|....|.:|...::|:. ..|.|.|.|
Mouse   479 FDECGDLVGNYSIINWHLSPEDGSIVFKEVGY-YNVYAKKGERLFINEGKILWSGFSREVPFSNC 542

  Fly   561 SLPCEVGMIKK-QQGD-TCCWICDSCESFEY--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMK 621
            |..|:.|..|. .:|: |||:.|..|...||  ..|...|..|....|...:..||.|.:|:::.
Mouse   543 SRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIAKEIEFLA 607

  Fly   622 WNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKP 686
            |...|.:.....|:.||.||:.|:.:|.|..:||:|:|:.|||||.|||.:|.|:.::...|.:|
Mouse   608 WTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLCCFSSSLFFIGEP 672

  Fly   687 TIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVL 751
            ...:|.|::...|:.|.:..|.:|.||||:..:|.:...::...|:.....|.::......:|::
Mouse   673 QDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWGLNLQFLLVFLCTFMQIV 737

  Fly   752 ITMIWMVVEPPGTRFYYPDRREVI-LKCKIQDMSFLFSQL-YNMILITICTIYAIKTRKIPENFN 814
            |.:||:...||.:...:....|:| :.|....:..|.|.: |..:|..||..:|.|:||:|||||
Mouse   738 ICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYTCLLAAICFFFAFKSRKLPENFN 802

  Fly   815 ESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFHP 878
            |:|||.|:|....|:|::|:|.|..|...:......:.|   |:||..|: |::..||||::|.|
Mouse   803 EAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAI---LAASFGLLACIFFNKVYIILFKP 864

  Fly   879 DKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNS 939
            .:|..:...:||.......| |:........||..    |:..||:.|:..|||.....||
Mouse   865 SRNTIEEVRSSTAAHAFKVA-ARATLRRPNISRKR----SSSLGGSTGSIPSSSISSKSNS 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mGluRNP_001259076.1 Periplasmic_Binding_Protein_Type_1 43..542 CDD:299141 155/533 (29%)
ANF_receptor 72..518 CDD:279440 129/461 (28%)
NCD3G 557..604 CDD:284890 17/50 (34%)
7tm_3 638..873 CDD:278433 79/237 (33%)
CasrNP_038831.2 Ligand-binding 1 (LB1). /evidence=ECO:0000250|UniProtKB:P41180 22..188 67/180 (37%)
PBP1_CaSR 33..530 CDD:380587 153/537 (28%)
Anion binding. /evidence=ECO:0000250|UniProtKB:P41180 66..70 2/3 (67%)
Ligand-binding 2 (LB2). /evidence=ECO:0000250|UniProtKB:P41180 189..324 37/136 (27%)
Anion binding. /evidence=ECO:0000250|UniProtKB:P41180 415..417 0/1 (0%)
NCD3G 538..591 CDD:400103 18/52 (35%)
Cysteine-rich (CR). /evidence=ECO:0000250|UniProtKB:P41180 542..612 22/69 (32%)
7tmC_CaSR 611..862 CDD:320409 84/253 (33%)
TM helix 1 612..636 CDD:320409 8/23 (35%)
TM helix 2 648..669 CDD:320409 10/20 (50%)
TM helix 3 678..700 CDD:320409 6/21 (29%)
TM helix 4 726..742 CDD:320409 2/15 (13%)
TM helix 5 769..792 CDD:320409 6/22 (27%)
TM helix 6 804..826 CDD:320409 9/21 (43%)
TM helix 7 831..856 CDD:320409 6/27 (22%)
Interaction with RNF19A. /evidence=ECO:0000250|UniProtKB:P41180 880..900 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 894..964 11/31 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3B9DN
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.