DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Tas1r1

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_114073.1	Gene:	Tas1r1 / 110326	MGIID:	1927505	Length:	842	Species:	Mus musculus

Alignment Length:	892	Identity:	230/892 - (25%)
Similarity:	388/892 - (43%)	Gaps:	138/892 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TQDSVSVSLPGDIILGGLFPVHEKGEGAPC-----GPKV--------YN-RGVQRLEAMLYAIDR 83
            |:.|...|||||.:|.|||.:|     |.|     .|.|        :| .|....:||.:.::.
Mouse    27 TESSPGFSLPGDFLLAGLFSLH-----ADCLQVRHRPLVTSCDRSDSFNGHGYHLFQAMRFTVEE 86

  Fly    84 VNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGP 148
            :||...:||.||:|..:.|.||..:.        |.|:|..|...|....: ....||.::|.
Mouse    87 INNSTALLPNITLGYELYDVCSESSN--------VYATLRVLAQQGTGHLE-MQRDLRNHSSK-- 140

  Fly   149 VFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILK 213
            |..:||...:..::..|.||..|.:|.||..:::..||.|.:|..|.||:|.|.:|...:|.:|:
Mouse   141 VVALIGPDNTDHAVTTAALLSPFLMPLVSYEASSVILSGKRKFPSFLRTIPSDKYQVEVIVRLLQ 205

  Fly   214 NFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVP--SAADDKVFDSIISKLQKKPNA 276
            :|.|.::|.:.|.|.||:.|::||.:.||.|.:|:|..:.||  :.|.|.....::.:|.:   |
Mouse   206 SFGWVWISLVGSYGDYGQLGVQALEELATPRGICVAFKDVVPLSAQAGDPRMQRMMLRLAR---A 267

  Fly   277 RG--VVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKL--LEGLEDIAE--GAITVELQ 335
            |.  ||:|:....|....::...|||:... ||||:.|.....:  :.|::.|..  |....:.|
Mouse   268 RTTVVVVFSNRHLAGVFFRSVVLANLTGKV-WIASEDWAISTYITNVPGIQGIGTVLGVAIQQRQ 331

  Fly   336 SEIIADFDRYMMQL---TPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAK 397
            ...:.:|:...:|.   .|.|.....|          |....|.
Mouse   332 VPGLKEFEESYVQAVMGAPRTCPEGSW----------CGTNQLC--------------------- 365

  Fly   398 TECD--DSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVW 460
            .||.  .::.:.| :|....|....|.:||||.|:.||.|..  |.
Mouse   366 RECHAFTTWNMPE-LGAFSMSAAYNVYEAVYAVAHGLHQLLG--CT------------------- 408

  Fly   461 YRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENS 525
                     |..|.....|..:.....|  .|:|: |....|.||.:||.|..|||:.:  ..|.
Mouse   409 ---------SGTCARGPVYPWQLLQQIY--KVNFL-LHKKTVAFDDKGDPLGYYDIIAW--DWNG 459

  Fly   526 SGYQYKVIGKWFNG---LQLNSETVVWN-KETEQPTSACSLPCEVGMIKKQQGD-TCCWICDSCE 585
            ..:.::|||.....   |.:|...:.|: |..:.|.|.|:..|..|..:...|. .||:.|..||
Mouse   460 PEWTFEVIGSASLSPVHLDINKTKIQWHGKNNQVPVSVCTRDCLEGHHRLVMGSHHCCFECMPCE 524

  Fly   586 --SFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLF 648
              :|....:..||:.||...|......:|::..::::.|:...:|:.:|.....:.|......||
Mouse   525 AGTFLNTSELHTCQPCGTEEWAPEGSSACFSRTVEFLGWHEPISLVLLAANTLLLLLLIGTAGLF 589

  Fly   649 AKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKT 713
            |....||:||::|..|.:.:|..::...|:.::...|||:.:|:|::....:||:|..|.|..::
Mouse   590 AWRLHTPVVRSAGGRLCFLMLGSLVAGSCSLYSFFGKPTVPACLLRQPLFSLGFAIFLSCLTIRS 654

  Fly   714 NRISRIFHSASKSAQRLKYISPQSQ----VVITTSLIAIQVLITMIWMVV-EPPGTRFYYPDRRE 773
            .::..||..::| .....:...|:.    .||.:|  .:.:.:.:.|:.: .|..||.|......
Mouse   655 FQLVIIFKFSTK-VPTFYHTWAQNHGAGIFVIVSS--TVHLFLCLTWLAMWTPRPTREYQRFPHL 716

  Fly   774 VILKC-KIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFV--- 834
            |||:| ::..:.||.:..:|::|.....:.:...:::|||:||:|.:.|::....:.|:||.
Mouse   717 VILECTEVNSVGFLVAFAHNILLSISTFVCSYLGKELPENYNEAKCVTFSLLLHFVSWIAFFTMS 781

  Fly   835 PIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKN 881
            .||.|   ||......|....:||...:  ..:.||.|:::..|:.|
Mouse   782 SIYQG---SYLPAVNVLAGLATLSGGFS--GYFLPKCYVILCRPELN 823

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	136/528 (26%)
		ANF_receptor	72..518	CDD:279440	118/458 (26%)
		NCD3G	557..604	CDD:284890	15/49 (31%)
		7tm_3	638..873	CDD:278433	62/243 (26%)
Tas1r1	NP_114073.1	PBP1_Taste_receptor	33..487	CDD:107358	140/540 (26%)
		ANF_receptor	75..458	CDD:279440	118/464 (25%)
		NCD3G	495..545	CDD:284890	15/49 (31%)
		7tm_3	589..815	CDD:278433	60/233 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000