DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Grm7

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_006505359.1	Gene:	Grm7 / 108073	MGIID:	1351344	Length:	924	Species:	Mus musculus

Alignment Length:	955	Identity:	435/955 - (45%)
Similarity:	571/955 - (59%)	Gaps:	113/955 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHIL 101
            |:.:.||:.||||||||.|| .|.|||......|:.||||||||:|::|:|||:||.:|:|..||
Mouse    42 SIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARIL 106

  Fly   102 DTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVAN 166
            ||||||||||.|||.||:|.:.. |||...|.:|..|...|...   |.||||.|.||||:.|||
Mouse   107 DTCSRDTYALEQSLTFVQALIQK-DTSDVRCTNGEPPVFVKPEK---VVGVIGASGSSVSIMVAN 167

  Fly   167 LLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGE 231
            :||||.|||:|.||||..|||..|:|.|:|.||||:||:.|:|||:|...|:||||:.|||||||
Mouse   168 ILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGE 232

  Fly   232 YGIEA---LHKEATERNVCIAVAEKVPSAADDKV--FDSIISKLQKKPNARGVVLFTRAEDARRI 291
            .|:|:   :.|||  ..:|||.:.::|....|:.  ||.||.:|...||:|.||:|...||.::|
Mouse   233 KGVESFTQISKEA--GGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQI 295

  Fly   292 LQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQR 356
            |.|||||:....|.|:.||.||.:...|...|||||||||::.:...:..||.|....|.|.|:|
Mouse   296 LAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 360

  Fly   357 NPWFAEYWEDTFNCVLT-SLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQF 420
            |.|||||||:.|||.|| |.|.|.|       ||.|        |....|:.:...||||.|.||
Mouse   361 NVWFAEYWEENFNCKLTISGSKKED-------TDRK--------CTGQERIGKDSNYEQEGKVQF 410

  Fly   421 VVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFY 485
            |:|||||.|:|||:::.|.|   :|               ||.:        ||:|....||:..
Mouse   411 VIDAVYAMAHALHHMNKDLC---AD---------------YRGV--------CPEMEQAGGKKLL 449

  Fly   486 NNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWN 550
             .|:.||:|...||:.|.|::.||...||||..|| ..|::...|::||:|.:.||||.|.:.|.
Mouse   450 -KYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQ-TTNTTNPGYRLIGQWTDELQLNIEDMQWG 512

  Fly   551 KET-EQPTSACSLPCEVGMIKK-QQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCY 613
            |.. |.|.|.|:|||:.|..|| |:|..|||.|:.|:.::|.:||.||:.|.....|..::..|.
Mouse   513 KGVREIPPSVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQ 577

  Fly   614 ALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCN 678
            .:.|..::|:|.:|:||:.:|:.||..|..|:..|.:.:|||:||||||||||.||.||.:||..
Mouse   578 NIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYII 642

  Fly   679 TFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITT 743
            ||.:||||.:..|..:|..:|:|..|.|:|||||||||.|||....||....:.|||.||:.||:
Mouse   643 TFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITS 707

  Fly   744 SLIAIQVLITMIWMVVEPPGTRFYY-------PDRREVILKCKIQDMSFLFSQLYNMILITICTI 801
            |||::|:|...||..|:||.....|       |::...:|||.|.|:..:.|..|:::|:..||:
Mouse   708 SLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTV 772

  Fly   802 YAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYE---VQTTTLCISISLSASVAL 863
            ||||||.:||||||:|.||||||||||:||||:||:|||..|.|   :|||||.||::|||||||
Mouse   773 YAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVAL 837

  Fly   864 VCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTN 928
            ..||.|||||::|||:.||:|       .:||..||...|..||..|  |.|
Mouse   838 GMLYMPKVYIIIFHPELNVQK-------RKRSFKAVVTAATMSSRLS--HKP------------- 880

  Fly   929 ASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVGERVEPICHI 973
                                   :.:.|||...|:.|.|:|..|:
Mouse   881 -----------------------SDRPNGEAKTELCENVDPNKHL 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	238/505 (47%)
		ANF_receptor	72..518	CDD:279440	213/451 (47%)
		NCD3G	557..604	CDD:284890	21/47 (45%)
		7tm_3	638..873	CDD:278433	131/244 (54%)
Grm7	XP_006505359.1	PBP1_mGluR_groupIII	43..511	CDD:380599	242/516 (47%)
		NCD3G	519..569	CDD:369426	22/49 (45%)
		7tmC_mGluR7	589..895	CDD:320567	158/350 (45%)
		TM helix 1	590..614	CDD:320567	9/23 (39%)
		TM helix 2	626..647	CDD:320567	13/20 (65%)
		TM helix 3	656..678	CDD:320567	10/21 (48%)
		TM helix 4	704..720	CDD:320567	7/15 (47%)
		TM helix 5	752..775	CDD:320567	7/22 (32%)
		TM helix 6	784..809	CDD:320567	20/24 (83%)
		TM helix 7	819..844	CDD:320567	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11721
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820