DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Grm6

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_775548.2	Gene:	Grm6 / 108072	MGIID:	1351343	Length:	871	Species:	Mus musculus

Alignment Length:	908	Identity:	391/908 - (43%)
Similarity:	543/908 - (59%)	Gaps:	75/908 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGV 71
            |.:.|:::.|:|.    |......|  .:.||.|.|.:.||||||||.:| .|..||.....:||
Mouse     2 GRLRVLLLWLAWW----LSQAGIAH--GAGSVRLAGGLTLGGLFPVHARGAAGRACGTLKKEQGV 60

  Fly    72 QRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNL---DTSGYECA 133
            .||||||||:||:|.||.:|||:.:|..:|||||||||||.|:|.||:|.:...   :.:...|
Mouse    61 HRLEAMLYALDRINADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGEEASVRC- 124

  Fly   134 DGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTV 198
            .|..|.||. |....|..|:|.|.||||:.|||:||||.|||:|.||||..|||.||:|.|:|.|
Mouse   125 PGGVPPLRA-APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVV 188

  Fly   199 PPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDKV 262
            |||::|:.|:|||::...|:||||:.|||:|||.|:||..:.:.|. .||||.:.|:|.......
Mouse   189 PPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGE 253

  Fly   263 FDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAE 327
            |..:|.:|.:.|||||:::|...:|.||:|:|.::|||:..|.|:.||.||.:...:..||:.|.
Mouse   254 FHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAV 318

  Fly   328 GAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKI 392
            ||||:..:...|..||:|.|..:.|.|:||.||||:||:.|||.|||...:.|.|.
Mouse   319 GAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDST--------- 374

  Fly   393 GVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSE 457
                 .:|....|:.:...||||.|.|||:|||||.|:|||::|...|...:.
Mouse   375 -----RKCTGEERIGQDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTG------------ 422

  Fly   458 SVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQR- 521
                          .||.|...||:... :|:..|.|...||:.|.|:..||...||||..||.
Mouse   423 --------------LCPAMEPTDGRTLL-HYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQAT 472

  Fly   522 --QENSSGYQYKVIGKWFNGLQLNSETVVWNKET-EQPTSACSLPCEVGMIKKQ-QGDTCCWICD 582
              ..:|.|||  .:|:|...|:|:.|.:.|:.:. |.|.|.|||||..|..||. :|..|||.|:
Mouse   473 NGSASSGGYQ--AVGQWAEALRLDMEALQWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCE 535

  Fly   583 SCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVL 647
            :|:.:.:..|||||:.|...:.|..:...|....:..:.|:|.:|.:|:.:|:.||..|:.:|..
Mouse   536 ACDGYRFQVDEFTCEACPGHMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIIAT 600

  Fly   648 FAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTK 712
            |.:::|||:||||||||||.||.||.:.|..||.::|:|....|..:|..:|:|.::.|||||||
Mouse   601 FMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAVCASRRLLLGLGTTLSYSALLTK 665

  Fly   713 TNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREV--- 774
            ||||.|||....:|.....:|||.||:|||..|.::||:..:.|:..:||.:...|.::|.|
Mouse   666 TNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPE 730

  Fly   775 ----ILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVP 835
                :|||.:.|:|.:....|:::|:..||:||||.|.:||.|||:|.|||||||||||||||||
Mouse   731 QARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVP 795

  Fly   836 IYFGTGNSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRK----LTMNSTV 891
            |:|||..|.|   :|||||.:|:||||||:|..||.||.|:::|||::||:|    |...||:
Mouse   796 IFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTM 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	216/506 (43%)
		ANF_receptor	72..518	CDD:279440	192/449 (43%)
		NCD3G	557..604	CDD:284890	21/47 (45%)
		7tm_3	638..873	CDD:278433	122/244 (50%)
Grm6	NP_775548.2	PBP1_mGluR_groupIII	39..500	CDD:380599	213/505 (42%)
		Glutamate binding. /evidence=ECO:0000250	169..171		1/1 (100%)
		NCD3G	508..558	CDD:400103	22/49 (45%)
		7tm_GPCRs	578..850	CDD:421689	133/271 (49%)
		TM helix 1	578..603	CDD:410628	8/24 (33%)
		TM helix 2	615..636	CDD:410628	12/20 (60%)
		TM helix 3	645..667	CDD:410628	10/21 (48%)
		TM helix 4	693..709	CDD:410628	6/15 (40%)
		TM helix 5	741..764	CDD:410628	7/22 (32%)
		TM helix 6	773..798	CDD:410628	22/24 (92%)
		TM helix 7	808..833	CDD:410628	15/24 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	848..871		3/11 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.830