DRSC/TRiP Functional Genomics Resources

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Protein Alignment mGluR and Grm5

DIOPT Version :9

Sequence 1:NP_001259076.1 Gene:mGluR / 43838 FlyBaseID:FBgn0019985 Length:976 Species:Drosophila melanogaster
Sequence 2:NP_001137306.1 Gene:Grm5 / 108071 MGIID:1351342 Length:1203 Species:Mus musculus


Alignment Length:992 Identity:373/992 - (37%)
Similarity:550/992 - (55%) Gaps:106/992 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 LVVVMVLSWSRVVDLKSPSNTHTQDS---VSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNR--- 69
            :|::::||   |:.||.......|.|   |...:|||||:|.||.||.:    |...||:.|   
Mouse     1 MVLLLILS---VLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQ----PTVDKVHERKCG 58

  Fly    70 ------GVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASL-NNLDT 127
                  |:||:||||:.::|:|:||.:||.||:|..|.|:|.....||.||::|:|.|| ::.:.
Mouse    59 AVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEE 123

  Fly   128 SG-YECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRF 191
            .| ..|.||||    ...|..|:.||||...|||::||.|||:||:|||::.::|:..|||||.|
Mouse   124 EGLVRCVDGSS----SFRSKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLF 184

  Fly   192 DLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPS 256
            ..|.|.||.|..|:.|:|||:|.:||:|||.:|:||:|||.|:||....:.:..:|||.:.|:.|
Mouse   185 KYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYS 249

  Fly   257 AADDKVFDSIISKLQKK-PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLE 320
            .|.::.||.::.||:.. |.||.|..|......|.:|.|.:|..|:..|..:.||||..:..:.:
Mouse   250 NAGEQSFDKLLKKLRSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTD 314

  Fly   321 GLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSA 385
            |.:..|.|.||::|||..:..||.|.::|.||||.|||||.|:|:..|.|.|...:       ..
Mouse   315 GYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNLRNPWFQEFWQHRFQCRLEGFA-------QE 372

  Fly   386 NSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTET 450
            ||..||       .|:.|  |:.:..:.|:||..||::|:|:.||.|||:....|...:.     
Mouse   373 NSKYNK-------TCNSS--LTLRTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAG----- 423

  Fly   451 RKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYD 515
                                 .|..|...||::..:: |:..:|..::|..:.||..||...||:
Mouse   424 ---------------------LCDAMKPIDGRKLLDS-LMKTNFTGVSGDMILFDENGDSPGRYE 466

  Fly   516 ILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGD-TCC 578
            |:|: ::.....:.|..:|.|.||.....:..||:|:.....|.||.|||.|.||. ::|: :||
Mouse   467 IMNF-KEMGKDYFDYINVGSWDNGELKMDDDEVWSKKNNIIRSVCSEPCEKGQIKVIRKGEVSCC 530

  Fly   579 WICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSI 643
            |.|..|:..|||:||:|||.|..|.||..|...|..:.:||::|.....:..:..|..|:..|..
Mouse   531 WTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLF 595

  Fly   644 VIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSA 708
            |.|:|....|||:|::|.|||.|.:|.||.:.|..||.|||||....|.|||.|||:..::.|||
Mouse   596 VTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSA 660

  Fly   709 LLTKTNRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDR 771
            |:||||||:||...:.|.  .::.:::|..:|:||...||.||:.|.:...::|||.....||..
Mouse   661 LVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSI 725

  Fly   772 REVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPI 836
            |||.|.|...::..:....||.:||..||.||.|||.:|.||||:|:|.||||||||||||||||
Mouse   726 REVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPI 790

  Fly   837 YFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYR------RS 895
            ||  |::|::  .|:|.|:||||:|||.|::.|||||::..|::|||.....|||.|      :|
Mouse   791 YF--GSNYKI--ITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGDGKS 851

  Fly   896 AAAVAQGAPTSSGYSRTHAPGTSA-----------------LTGGAVGTNASSSTLPTQNSPHLD 943
            ::|.::.:...:.:.|..:.|.:.                 ...|::| |...:|:.:.|...:.
Mouse   852 SSAASRSSSLVNLWKRRGSSGETLRYKDRRLAQHKSEIECFTPKGSMG-NGGRATMSSSNGKSVT 915

  Fly   944 EASAQTNVAHKTNGEFL 960
            .|..:.:    |.|:.|
Mouse   916 WAQNEKS----TRGQHL 928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mGluRNP_001259076.1 Periplasmic_Binding_Protein_Type_1 43..542 CDD:299141 188/510 (37%)
ANF_receptor 72..518 CDD:279440 168/448 (38%)
NCD3G 557..604 CDD:284890 25/48 (52%)
7tm_3 638..873 CDD:278433 115/236 (49%)
Grm5NP_001137306.1 PBP1_mGluR_groupI 26..496 CDD:380597 190/521 (36%)
Glutamate binding. /evidence=ECO:0000250 172..174 0/1 (0%)
NCD3G 507..557 CDD:400103 25/49 (51%)
7tmC_mGluR5 577..826 CDD:320566 119/252 (47%)
TM helix 1 578..602 CDD:320566 6/23 (26%)
TM helix 2 614..635 CDD:320566 10/20 (50%)
TM helix 3 644..666 CDD:320566 12/21 (57%)
TM helix 4 694..710 CDD:320566 7/15 (47%)
TM helix 5 735..758 CDD:320566 7/22 (32%)
TM helix 6 770..792 CDD:320566 18/21 (86%)
TM helix 7 795..820 CDD:320566 12/26 (46%)
Allosteric effector binding. /evidence=ECO:0000250 804..808 2/3 (67%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 892..1054 9/42 (21%)
PHA03247 <982..1186 CDD:223021
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1120..1182
GluR_Homer-bdg 1154..1203 CDD:402304
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49358
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.920

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