DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Grm3

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_862898.1	Gene:	Grm3 / 108069	MGIID:	1351340	Length:	879	Species:	Mus musculus

Alignment Length:	914	Identity:	449/914 - (49%)
Similarity:	589/914 - (64%)	Gaps:	83/914 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TILVVVMVLSWSR--VVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGA-PCGPKVYNRG 70
            |.|.|:|:..:|:  :|.|    ..|......:.:.||::||||||::|||.|. .||....:||
Mouse     5 TRLQVLMLALFSKGFLVSL----GDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRG 65

  Fly    71 VQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADG 135
            :|||||||:|||.:|.|..:|||:.:|||||||||||||||.|||:||||||..:|.:.|.|.||
Mouse    66 IQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDG 130

  Fly   136 SSPQLRKNASSGP--VFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTV 198
            |. .:::|.   |  :.|||||||||||:|||||||||.|||:|.|||:..||||:|:|.|||||
Mouse   131 SY-AIQENI---PLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTV 191

  Fly   199 PPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVF 263
            |||.:|:.|:.:||:.|||:||||:.|||.|||.||||..:||..||:|||.||||..:...|.:
Mouse   192 PPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSY 256

  Fly   264 DSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEG 328
            ||:|.:|.:|||||.||||.|::|:|.::.||.|.|.|  |.|:||||||.|:.:::|.|.:|.|
Mouse   257 DSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNAS--FTWVASDGWGAQESIVKGSEHVAYG 319

  Fly   329 AITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIG 393
            |||:||.|..:..||||...|.|..|.|||||.::||..|.|.|         .|..|.
Mouse   320 AITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL---------QNKRNH------ 369

  Fly   394 VKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRC-NTQSDQTTETRKHLQSE 457
               :..||....: :...||||||..|||:||||.|:|||.:....| ||
Mouse   370 ---RQICDKHLAI-DSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNT--------------- 415

  Fly   458 SVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFI------DLAGSEVKFDRQGDGLARYDI 516
                        ::.|..|...|||:.|.:|||.::|.      ..|.|.||||..|||:.||::
Mouse   416 ------------TKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNV 468

  Fly   517 LNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQ-GDTCCWI 580
            .|:  |.....|.|..:|.|...|.|:.:::.|::.: .|||.||.||....:|..| ||.||||
Mouse   469 FNF--QHIGGKYSYLKVGHWAETLYLDVDSIHWSRNS-VPTSQCSDPCAPNEMKNMQPGDVCCWI 530

  Fly   581 CDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVI 645
            |..||.:||:.|||||.|||||.||.||...||.|...|::|...:|:.|:.||..|...|.|||
Mouse   531 CIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIRWEDAWAIGPVTIACLGFMCTCIVI 595

  Fly   646 VLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALL 710
            .:|.|:::||||:||||||.|.||||:.:.||.||..||||:...|.|:|.|:|..|:|.|||||
Mouse   596 TVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALL 660

  Fly   711 TKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFY-YPDRRE- 773
            ||||.|:|||......|||.|:|||.|||.|...||.:|:::..:|:::|.||||.| .|::||
Mouse   661 TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRET 725

  Fly   774 VILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYF 838
            |||||.::|.|.|.|..|:::|:.:||:||.||||.||||||:|||||||||||||||||:||::
Mouse   726 VILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFY 790

  Fly   839 GTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNV--RKLTMN-------STVYRR 894
            .|.:.|.|||||:|||:|||..|.|.||::|||:|::|.|.|||  .:|.:|       :|.|.:
Mouse   791 VTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQ 855

  Fly   895 SAAA 898
            |:|:
Mouse   856 SSAS 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	246/508 (48%)
		ANF_receptor	72..518	CDD:279440	223/454 (49%)
		NCD3G	557..604	CDD:284890	29/47 (62%)
		7tm_3	638..873	CDD:278433	137/236 (58%)
Grm3	NP_862898.1	PBP1_mGluR_groupII	33..494	CDD:380598	247/514 (48%)
		Glutamate binding. /evidence=ECO:0000250	172..174		1/1 (100%)
		NCD3G	505..555	CDD:400103	30/49 (61%)
		7tmC_mGluR3	575..828	CDD:320564	143/252 (57%)
		TM helix 1	576..600	CDD:320564	10/23 (43%)
		TM helix 2	612..633	CDD:320564	12/20 (60%)
		TM helix 3	642..664	CDD:320564	13/21 (62%)
		TM helix 4	690..706	CDD:320564	4/15 (27%)
		TM helix 5	733..756	CDD:320564	9/22 (41%)
		TM helix 6	768..790	CDD:320564	19/21 (90%)
		TM helix 7	797..822	CDD:320564	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836773
Domainoid	1	1.000	404	1.000	Domainoid score	I718
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H651
Inparanoid	1	1.050	837	1.000	Inparanoid score	I448
Isobase	1	0.950	-	0	Normalized mean entropy	S3570
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003689
OrthoInspector	1	1.000	-	-		otm42790
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24060
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2555
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840