Protein Alignment mGluR and Grm2

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001153825.1
• Gene: Grm2 / 108068
• MGIID: 1351339
• Length: 872
• Species: Mus musculus
• Alignment Length: 914
• Identity: 438/914 - (47%)
• Similarity: 574/914 - (62%)
• Gaps: 98/914 - (10%)

  Fly    39 VSLPGDIILGGLFPVHEKGEGA-PCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILD 102
            ::|.||::||||||||:||..| .|||...:||:|||||||:|:||:|.||::|||:.:|.||||
Mouse    26 LTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILD 90

  Fly   103 TCSRDTYALNQSLQFVRASLN-NLDTSGYECADGSSPQLRKNASSGP--VFGVIGGSYSSVSLQV 164
            :||:||:||.|:|.||||||: ..|.|.:.|.|||...|    |..|  :.||||||||.||:||
Mouse    91 SCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATL----SDAPTAITGVIGGSYSDVSIQV 151

  Fly   165 ANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSY 229
            |||||||.|||:|.|||:..||||:|:|.||||||||.||:.|:.:||:.|||:||||:.|||.|
Mouse   152 ANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDY 216

  Fly   230 GEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQA 294
            ||.||||...||..||:|:|.:|||..|.....|:.::..|.:||:||..|||||:||||.:|.|
Mouse   217 GETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAA 281

  Fly   295 AKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPW 359
            .:|.|.|  |.|:||||||..:.::.|.|..||||||:||.|..|:||..|...|.|..|.||||
Mouse   282 TQRLNAS--FTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQNLDPWNNSRNPW 344

  Fly   360 FAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDA 424
            |.|:||:.|.|   |...:...::|..:                      |.:|||||..|||:|
Mouse   345 FREFWEERFRC---SFRQRDCAAHSLRA----------------------VPFEQESKIMFVVNA 384

  Fly   425 VYAFAYALHNLHNDRC-NTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNY 488
            |||.|:||||:|...| ||                           ::.|..|...:|:..|.::
Mouse   385 VYAMAHALHNMHRALCPNT---------------------------TRLCDAMRPVNGRRLYKDF 422

  Fly   489 LLNVSFIDL------AGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETV 547
            :|||.| |.      ...||:|||.|||:.||:|..|.|..|.. |:|:.:|.|..||.|::..:
Mouse   423 VLNVKF-DAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGNGR-YRYQKVGYWAEGLTLDTSII 485

  Fly   548 VWNKET--EQPTSACSLPCEVGMIKK-QQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADK 609
            .|...:  ..|.|.||.||....:|. |.|:.|||:|..|:.:||..|||||.|||.|.||.|..
Mouse   486 PWASPSAGTLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASL 550

  Fly   610 LSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILV 674
            ..|:.|..:|::|...:|:.|:.||..|...|..|:.:|.:::.||:|:||||||.|.||.|:.:
Mouse   551 TGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFL 615

  Fly   675 CYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQV 739
            |||.||..||||:...|.|:|.|:|..||:.|||||||||||:|||..|.:.|||.::|||.|||
Mouse   616 CYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQV 680

  Fly   740 VITTSLIAIQVLITMIWMVVEPPGT-RFYYPDRREVI-LKCKIQDMSFLFSQLYNMILITICTIY 802
            .|..:||:.|:||...|:|||.||. :...|:||||: |:|..:|.|.|.|..||::||.:||:|
Mouse   681 AICLALISGQLLIVAAWLVVEAPGIGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLY 745

  Fly   803 AIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLY 867
            |.||||.||||||:|||||||||||||||||:||::.|.:.|.|||||:|:|:|||.||.|.||:
Mouse   746 AFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLF 810

  Fly   868 SPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSS 932
            :||::|::|.|.|||                |:..||||...|.  ||..||    .:|..:.|.
Mouse   811 APKLHIILFQPQKNV----------------VSHRAPTSRFGSA--APRASA----NLGQGSGSQ 853

  Fly   933 TLPT 936
            .:||
Mouse   854 LVPT 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	244/513 (48%)
		NCD3G	556..605	CDD:462210	25/49 (51%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	141/252 (56%)
		TM helix 1	625..650	CDD:320600	8/24 (33%)
		TM helix 2	662..683	CDD:320600	12/20 (60%)
		TM helix 3	692..716	CDD:320600	15/23 (65%)
		TM helix 4	738..758	CDD:320600	9/19 (47%)
		TM helix 5	781..807	CDD:320600	13/25 (52%)
		TM helix 6	815..838	CDD:320600	20/22 (91%)
		TM helix 7	845..870	CDD:320600	15/24 (63%)
Grm2	NP_001153825.1	PBP1_mGluR_groupII	26..480	CDD:380598	244/513 (48%)
		NCD3G	496..546	CDD:462210	25/49 (51%)
		7tmC_mGluR2	566..819	CDD:320563	141/252 (56%)
		TM helix 1	566..591	CDD:320563	8/24 (33%)
		TM helix 2	603..624	CDD:320563	12/20 (60%)
		TM helix 3	633..657	CDD:320563	15/23 (65%)
		Important for interaction with HTR2A. /evidence=ECO:0000250	677..685		4/7 (57%)
		TM helix 4	679..699	CDD:320563	9/19 (47%)
		TM helix 5	724..750	CDD:320563	13/25 (52%)
		TM helix 6	758..781	CDD:320563	20/22 (91%)
		TM helix 7	788..813	CDD:320563	15/24 (63%)