Protein Alignment mGluR and olfcv1

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_073785919.1
• Gene: olfcv1 / 101884304
• ZFINID: ZDB-GENE-050419-263
• Length: 849
• Species: Danio rerio
• Alignment Length: 879
• Identity: 250/879 - (28%)
• Similarity: 409/879 - (46%)
• Gaps: 109/879 - (12%)

  Fly    43 GDIILGGLFPVHEKGEGAP-----------C---GPKVYNRGVQRLEAMLYAIDRVNNDPNILPG 93
            ||..:||:||:|.:.|..|           |   .|..::..:    .|..|::.:||..::||.
Zfish    35 GDFTIGGIFPLHYRVELPPTDYMKKPLTAMCRGFDPMAFHWAL----TMGLAVEEINNRKDLLPE 95

  Fly    94 ITIGVHILDTCSRDTYALNQSLQFVRASLNNLD-TSGYECADGSSPQLRKNASSGPVFGVIGGSY 157
            .|:...|.|:|:....|    .:.|.|:||..| ...:.|:..|           |:.|:||.|.
Zfish    96 HTLAYRIFDSCATPVMA----QKAVLAALNGQDVVQSFMCSGAS-----------PLLGLIGESG 145

  Fly   158 SSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVST 222
            ||.|:.|:..|..|.||.:|..||...|||:.:|..|.|.||.|.:|..|:..:||.|:|:::..
Zfish   146 SSQSIVVSRTLEPFRIPMISYFSTCSCLSDRKQFPTFFRVVPSDDYQVKAIAQLLKRFDWTWIGV 210

  Fly   223 IHSEGSYGEYGIEALHKEATERNVCIAVAEKVP-SAADDKVFDSIISKLQKKPNARGVVLFTRAE 286
            :..:..||.:.::.|.:|.....:|:|..|.:| ....::|..  |.|:.|:..|:.||:|:...
Zfish   211 VTEDHDYGRFALQGLKREIENTKICLAYHEMIPKDYTQERVLK--ILKVMKESTAKVVVVFSGEG 273

  Fly   287 DARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTP 351
            :....|......|:: ...||||:.|.....|.| .....:|.|...::...:.....|:..:||
Zfish   274 EFYPFLTEFVAQNIT-GIQWIASEAWVTASMLAE-TYSFLDGTIGFAIRQGHVPGLQDYIRTVTP 336

  Fly   352 ETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSY--RLSEKVGYEQ 414
            |.....|...|.||..:.|       .|.||..::...:..|.:...:...:|  ..|.:|.|.
Zfish   337 ERYPSIPQVQELWEALYGC-------SPSTSTLSSHLPSCTGKEILRKEYSAYMNTSSPRVTYN- 393

  Fly   415 ESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRK-HLQSESVWYRKISTDTKSQACPDMAN 478
                  |..||||||::||||            .|.|. |...|::            :|.::.|
Zfish   394 ------VYKAVYAFAHSLHNL------------IECRNGHGPFENL------------SCANLNN 428

  Fly   479 YDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQ-- 541
            ....:. .:||..:|| .::|.||.||.:||.:..||::|:||.. |...|:..:| .::|.|
Zfish   429 VFPWQL-QHYLQEISF-SISGEEVNFDIKGDAIPSYDLINWQRSA-SGDMQFIKVG-LYDGAQHS 489

  Fly   542 -----LNSETVVW-NKETEQPTSACSLPCEVGMIKK-QQGDT-CCWICDSCE--SFEYVYDEFTC 596
                 :..:.:.| |::|:.|.|.||..|..|..|. :.|.: ||:.|..|:  ......|...|
Zfish   490 GKELVIEKQAIAWSNQQTKVPVSVCSNGCTPGYRKAVRHGQSLCCFDCVPCDIGKISNQTDSVDC 554

  Fly   597 KDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASG 661
            ..|....|...::..|....|:::..::: .:....||:.|..||..|:.:|..|..||:||.:.
Zfish   555 LSCPEDYWSNVNRTECIQKVIEFLSHDAM-GMTLTVIAVAGAFLTITVLGIFLYNKGTPIVRVNN 618

  Fly   662 RELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKS 726
            .|||:.:|..:..|:......|.:||..||:|:.....:.||:..|.:|.||..:...|.:....
Zfish   619 SELSFFILVSLTFCFLCALIFIGEPTSWSCMLRHTAFSITFSLCISCILGKTLVVLAAFTATRPG 683

  Fly   727 AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPP----GTRFYYPDRREVILKCKI-QDMSFL 786
            ...:|::.|..|.:|......:||||..:|:||.||    .|::   .:.::||.|.: .|::|.
Zfish   684 NNIMKWLGPTQQRIIIFCCTLVQVLICTVWLVVSPPFPYRNTKY---QQSKIILDCSVGSDLAFW 745

  Fly   787 FSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTL 851
            ....|..:|..:|...|...||:|.||||:|:|.|:|...|.:||||||.|..:...:   ||.:
Zfish   746 CVLGYIGLLACVCFFLAFLARKLPGNFNEAKYITFSMIIFCTVWLAFVPAYVSSPGKF---TTAV 807

  Fly   852 CISISLSASVALV-CLYSPKVYILVFHPDKNVRK 884
            .|...|::|..|: ||::||.||::..|:||.::
Zfish   808 EIFAILASSFGLLFCLFAPKCYIILVKPEKNTKQ 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	142/524 (27%)
		NCD3G	556..605	CDD:462210	15/52 (29%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	84/256 (33%)
		TM helix 1	625..650	CDD:320600	7/24 (29%)
		TM helix 2	662..683	CDD:320600	5/20 (25%)
		TM helix 3	692..716	CDD:320600	7/23 (30%)
		TM helix 4	738..758	CDD:320600	7/19 (37%)
		TM helix 5	781..807	CDD:320600	6/25 (24%)
		TM helix 6	815..838	CDD:320600	12/22 (55%)
		TM helix 7	845..870	CDD:320600	8/25 (32%)
olfcv1	XP_073785919.1	None