Protein Alignment mGluR and grm8

DIOPT Version :9

• Sequence 1: NP_001259076.1
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_012815421.1
• Gene: grm8 / 100497088
• XenbaseID: XB-GENEPAGE-22062955
• Length: 919
• Species: Xenopus tropicalis
• Alignment Length: 968
• Identity: 428/968 - (44%)
• Similarity: 575/968 - (59%)
• Gaps: 88/968 - (9%)

  Fly     4 KNNNGTILVVVMVLSWSRVVDLKSPSNTHTQD-SVSVSLPGDIILGGLFPVHEKGE-GAPCGPKV 66
            |:...||...::.|:...:........|:.|: :.|:.:.||||||||||||.:|| |.|||...
 Frog     9 KSTQSTICPCILFLTMYILGISSMMQTTNGQEYAHSIRVEGDIILGGLFPVHARGERGVPCGDLK 73

  Fly    67 YNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYE 131
            ..:|:.|||||:||||::|.|.::||.||:||.||||||||||||.|||.||:|.:.. |.|...
 Frog    74 KEKGIHRLEAMMYAIDQINKDSDLLPNITLGVRILDTCSRDTYALEQSLTFVQALIEK-DASDVR 137

  Fly   132 CADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFAR 196
            ||:|..|...|   ...:.||||.:.||||:.|||:||||.|||:|.||||..|||.:|:|.::|
 Frog   138 CANGDPPIFTK---PDKIVGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNSRYDFYSR 199

  Fly   197 TVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATE-RNVCIAVAEKVPSAADD 260
            .||||::|:.|:|||:....|:||||:.|||:|||.|:||..:.:.| ..||||.:.|:|.....
 Frog   200 VVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQLSREIGGVCIAQSLKIPREPKV 264

  Fly   261 KVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDI 325
            ..||.||.:|.:.||||.:::|...:|.||||:||||.|.:..|.||.||.||.:...:...|:|
 Frog   265 GEFDKIIRRLLETPNARAIIIFANEDDIRRILEAAKRNNQTGHFLWIGSDSWGSKIAPVYQQEEI 329

  Fly   326 AEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDN 390
            ||||:|:..:...|..||||....:...|:||.||||:||:.|.|
 Frog   330 AEGAVTILPKRASIDGFDRYFRSRSLANNRRNVWFAEFWEENFGC-------------------- 374

  Fly   391 KIGVKAK-----TECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTET 450
            |:|...|     .:|....|:.....:|||.|.|||:||||:.|:||:|:|.|.|.....
 Frog   375 KLGSHGKRNNHFKKCTGLERIGRHSSFEQEGKVQFVIDAVYSMAHALNNMHKDLCPGYIG----- 434

  Fly   451 RKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYD 515
                                 .||.|...||||.. :|:..|:|...||:.|.|:..||...|||
 Frog   435 ---------------------LCPRMKTIDGKELL-SYIRAVNFNGSAGTPVTFNENGDAPGRYD 477

  Fly   516 ILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVW-NKETEQPTSACSLPCEVGMIKKQ-QGDTCC 578
            |..||....::  :|||||:|.|.|.||.|.:.| ::|..||||.|||||:.|..||. :|..||
 Frog   478 IYQYQMTNKTA--EYKVIGQWTNQLHLNVEDMQWTSREHTQPTSVCSLPCKPGERKKTVKGVPCC 540

  Fly   579 WICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSI 643
            |.|:.||.:.|..||.||:.|.....|.|::..|..:.|..::|:|.:|::|:.|||.||..|:.
 Frog   541 WHCERCEGYHYQVDELTCELCPLDQKPNANRTGCQLIPIIKLEWHSPWAVVPVFIAILGIVATTF 605

  Fly   644 VIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSA 708
            |||.|.:.:|||:||||||||||.||.||.:||..||.:|..|.:..|.|:|..:|:|....|:|
 Frog   606 VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMIGTPDMFVCSLRRIFLGLGMCFSYAA 670

  Fly   709 LLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRR- 772
            ||||||||.|||....||....|:|||.||:|||.|||::|::...||.||:||.....|.::|
 Frog   671 LLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLIGVFIWFVVDPPHIIIDYGEQRT 735

  Fly   773 ------EVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWL 831
                  ..:|||.|.::|.:.|..|:::|:..||:||||||.:||.|||:|.|||||||||||||
 Frog   736 PDPINARGVLKCDISELSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWL 800

  Fly   832 AFVPIYFGTGNSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYR 893
            ||:||:|||..|.|   :|||||.||:||||||:|..||.|||||::.||::||:|       .:
 Frog   801 AFIPIFFGTAQSAERMYIQTTTLTISMSLSASVSLGMLYMPKVYIIILHPEQNVQK-------RK 858

  Fly   894 RSAAAVAQGAPTSS-----GYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEAS 946
            ||..||...|...|     |..|.:....:.|. .::.||....:  |||.|:..:.|
 Frog   859 RSFKAVVTAATMQSKLIQKGNDRPNGEVKTELC-ESLETNRRRPS--TQNKPYFPDPS 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	223/505 (44%)
		ANF_receptor	72..518	CDD:279440	194/451 (43%)
		NCD3G	557..604	CDD:284890	23/47 (49%)
		7tm_3	638..873	CDD:278433	133/244 (55%)
grm8	XP_012815421.1	PBP1_mGluR_groupIII	49..509	CDD:107371	226/512 (44%)
		ANF_receptor	79..478	CDD:279440	192/449 (43%)
		NCD3G	518..565	CDD:284890	23/46 (50%)
		7tm_3	600..845	CDD:278433	133/244 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000