DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and vn2r1p

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_012818896.1	Gene:	vn2r1p / 100496607	XenbaseID:	XB-GENE-876508	Length:	908	Species:	Xenopus tropicalis

Alignment Length:	951	Identity:	255/951 - (26%)
Similarity:	443/951 - (46%)	Gaps:	150/951 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DIILGGLFPVH-------EKGEGAPCGPKV--YN-RGVQRLEAMLYAIDRVNNDPNILPGITIGV 98
            ::|:||:||.|       :.....|..||.  :| |.::...||::||:::|...:|||.||:|.
Frog    45 ELIIGGMFPFHFRTILQNDSAMEEPKSPKCEGFNFRSLRWARAMIFAINKINKQRDILPNITLGY 109

  Fly    99 HILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQ 163
            .|.|||...:.|:..:|.|:..  .|.....:.|:.|:           |:..|:|...|::|:.
Frog   110 QIFDTCFTISKAVEGTLSFLTG--QNETHPNFRCSAGA-----------PLAAVVGAGGSALSIA 161

  Fly   164 VANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGS 228
            .|.:|.|::.|||..||:...||||.:|..|.||:..||.||..:..::..|.|::|.||.::..
Frog   162 TARILGLYYFPQVGYASSCSVLSDKFQFPSFLRTIASDTTQSKGIAALVTYFGWTWVGTIAADDD 226

  Fly   229 YGEYGIEALHKEATERN-VCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRIL 292
            ||:|||: |.||..|:| |||:.:|.:|...:....|.|::.: :|..|..:|:|:...|...::
Frog   227 YGKYGIK-LFKEEVEKNGVCISFSETLPRIYNKDSIDKIVATI-RKSTANIIVIFSSDIDLSSLM 289

  Fly   293 QAAKRANLSQPFHWIASDGWGKQQKLLEGLE-DIAEGAITVELQSEIIADFDRYMMQLTPETNQR 356
            :|....|::.. .:|:|:.|.....:.:... ....|.|...:|...|..|:.::..:.|| :..
Frog   290 EALAETNITGK-TYISSEAWTTSALIAKPKHFHFLGGTIGFAVQRASIPGFEEFLHDIHPE-HGN 352

  Fly   357 NPWFAEYWEDTFNCV--------LTSLSV-------KPDTSNSANSTDNKIGVKAKTECDDSYRL 406
            :....|:||:.|||.        .|::|:       |.|.|....:....:.....|..|    :
Frog   353 DDLVYEFWEEAFNCTWPTNRALFYTNISLEAAMAGRKRDVSPIPCTGRENLNTSLNTYSD----V 413

  Fly   407 SE-KVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKS 470
            || ::.|.       |..|||..|:|||:|  |.|         ..||            ....:
Frog   414 SELRITYN-------VYKAVYTIAHALHDL--DVC---------VPKH------------GPFPN 448

  Fly   471 QACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQEN----------- 524
            ..|.::.:::..:.. .||....|..|....:.||..||....||:||:|.::|
Frog   449 NECANVLDFEPWQLM-YYLKKAKFTSLNNETISFDDSGDIKGHYDVLNWQWKDNQTMSFVKIGYY 512

  Fly   525 ---SSGYQYKVIGKWFNGLQLNSETVVWN-KETEQPTSACSLPCEVGMIKK-QQGD-TCCWICDS 583
               :|||::|:          ::.:::|| ..|..|.|.||..|..|..|. :||: .||:.|.:
Frog   513 KDLTSGYEFKI----------DNSSILWNTPNTMPPRSVCSESCIPGTRKGIRQGEPVCCFDCIA 567

  Fly   584 CESFEYV--YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIV 646
            |...|..  .|...|..|....|..:.:..|...:::::..:....:..:.:::||.:|.....|
Frog   568 CADGEITNETDARECISCPSDFWSNSHRNECVLKEVEFLATDEALGITLIFLSVFGASLVIAFTV 632

  Fly   647 LFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLT 711
            ::....:|.||:|:.|.||:.:...::..:..:...:.||...||:.::..:.:|||:..|::|.
Frog   633 VYIMYRETALVKANSRSLSFLIQVSLVFTFMTSVLFVGKPEQWSCMARQITLALGFSLCLSSILG 697

  Fly   712 KTNRISRIFHSA-SKSAQR----LKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDR 771
            ||..:.....|| ||.|:|    ||   |..|:::....:.||..|...::::.||   :.|.:.
Frog   698 KTIVLMLRKKSAKSKLAERGHDALK---PVYQIIVAVIGLTIQAGICTAYLLIYPP---WVYKNM 756

  Fly   772 R----EVILKCKIQDMSFLFSQL-YNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWL 831
            .    ::||:|....:.||.|.. :::.|..:..|.|...||:|:||||:|||.|.|....|:|:
Frog   757 ESQNVKIILECNEGSIEFLCSMFGFDVFLAILSFITAFIARKLPDNFNEAKFITFGMLVFFIVWI 821

  Fly   832 AFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFHPDKNVRKLTMNSTVYRRS 895
            :|||.|..|...::|......|   |::|..|: |::.||.||::..|::|..::
Frog   822 SFVPAYLSTRGKFKVAVEIFAI---LASSFGLLGCIFVPKSYIILLKPERNTEEI---------- 873

  Fly   896 AAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPT 936
               |...|.|:.    ..||.|||    ::.:..:|:|:.|
Frog   874 ---VGGRAATND----KSAPATSA----SITSEINSTTVST 903

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	144/539 (27%)
		ANF_receptor	72..518	CDD:279440	125/463 (27%)
		NCD3G	557..604	CDD:284890	16/50 (32%)
		7tm_3	638..873	CDD:278433	72/245 (29%)
vn2r1p	XP_012818896.1	PBP1_CaSR	47..530	CDD:380587	144/544 (26%)
		NCD3G	538..591	CDD:369426	17/52 (33%)
		7tmC_V2R-like	611..866	CDD:320407	76/263 (29%)
		TM helix 1	611..636	CDD:320407	4/24 (17%)
		TM helix 2	648..669	CDD:320407	3/20 (15%)
		TM helix 3	678..702	CDD:320407	7/23 (30%)
		TM helix 4	728..744	CDD:320407	3/15 (20%)
		TM helix 5	771..797	CDD:320407	6/25 (24%)
		TM helix 6	805..828	CDD:320407	11/22 (50%)
		TM helix 7	833..858	CDD:320407	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910