DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and grm1

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017949676.2	Gene:	grm1 / 100495945	XenbaseID:	XB-GENE-980107	Length:	1172	Species:	Xenopus tropicalis

Alignment Length:	897	Identity:	350/897 - (39%)
Similarity:	518/897 - (57%)	Gaps:	94/897 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVH-----EKGEGAPCGPKVYNRGVQRLEAMLYAI 81
            :|...||.:....|       ||||:|.||.||     ||.....||......|:||:|||.:.:
Frog    42 LVCASSPRSVARMD-------GDIIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTL 99

  Fly    82 DRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNL----DTSGYECADGS-SP--Q 139
            |::|.|.|:||.||:|..|.|:|...:.||.||::|:|.||.::    |.:| :|.|.: :|  :
Frog   100 DQINMDQNLLPNITLGTEIRDSCWHSSVALEQSIEFIRDSLISMRDEKDGAG-KCLDATPTPHGR 163

  Fly   140 LRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQ 204
            ::|     |:.||||...|||::||.|||:||.|||::.::|:..|||||.:..|.|.||.|..|
Frog   164 IKK-----PIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDILQ 223

  Fly   205 SVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISK 269
            :.|::||:|.:||:|||.:|:||:|||.|:||..:.|.:..:|||..:|:.|.|.::.||.::.|
Frog   224 ARAMLDIVKRYNWTYVSAVHTEGNYGESGMEAFKEMAAQEGLCIAHTDKIYSNAGERNFDRLLKK 288

  Fly   270 LQKK-PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVE 333
            |::: |.||.|:.|......|.||.|.:|..::..|..|.||||..:.:::||.|..|.|.||::
Frog   289 LRERLPKARVVICFCEGMTVRGILMAMRRLGVAGEFLLIGSDGWADRDEVIEGYEAEANGGITMK 353

  Fly   334 LQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKT 398
            |||..:..||.|.:.|..:||.|||||.|:|:..|.|.:..   .|..:.|           .|.
Frog   354 LQSAEVMSFDTYYLGLRLDTNSRNPWFTEFWQHRFQCRIPG---HPQENRS-----------FKK 404

  Fly   399 ECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRK 463
            .|..:..|.|  .|.|:||..||::|:||.|:.||::|:..|          ..|:
Frog   405 ICKGNETLEE--NYVQDSKMGFVINAIYAMAHGLHDMHSALC----------PGHV--------- 448

  Fly   464 ISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGY 528
                   ..|..|...||.:.. .:|:..||:.::|.:|.||.:||...||||:|.|:.| .:.|
Frog   449 -------GLCDAMKPIDGSKLL-EFLIKASFLGISGEDVWFDEKGDAPGRYDIMNLQQIE-PNRY 504

  Fly   529 QYKVIGKWFNG--------LQLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGD-TCCWICDS 583
            .|..||.|..|        :|.|...:|        .|.||.||..|.||. ::|: :|||||..
Frog   505 DYVQIGAWHEGILSMDDYRIQANKSGIV--------RSVCSDPCSKGEIKVIRKGEVSCCWICTP 561

  Fly   584 CESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLF 648
            |:..|:|.||||||.|..|.||......|..:.::|::|:.:.::|.:|.:..||.:|..|.::|
Frog   562 CKENEFVQDEFTCKACDQGAWPNPGLTGCEPIPVKYLQWSDIESIIAVAFSCLGILITMFVTLIF 626

  Fly   649 AKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKT 713
            ....|||:|::|.|||.|.:|.||.:.|...|.||||||..||.|||..:|:..::.||||:|||
Frog   627 ILYRDTPVVKSSSRELCYIILAGIFLGYICPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKT 691

  Fly   714 NRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVIL 776
            |||:||...:.|.  .::.:::|..:||||.:.||::|:.:.:..:::|||.....||..:||.|
Frog   692 NRIARILAGSKKKICTRKPRFMSACAQVVIASILISLQLSLVVSLIIMEPPMPILSYPSIKEVYL 756

  Fly   777 KCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTG 841
            .|...::..:....||.:||..||.||.|||.:|.||||:|:|.||||||||||||||||||  |
Frog   757 ICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--G 819

  Fly   842 NSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYR 893
            ::|::.||:  .::|||.:|||.|:::||:||::..|::|||.....|.|.|
Frog   820 SNYKIITTS--FAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVR 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	192/519 (37%)
		ANF_receptor	72..518	CDD:279440	169/453 (37%)
		NCD3G	557..604	CDD:284890	25/48 (52%)
		7tm_3	638..873	CDD:278433	109/236 (46%)
grm1	XP_017949676.2	PBP1_mGluR_groupI	49..522	CDD:380597	193/529 (36%)
		NCD3G	533..583	CDD:400103	25/49 (51%)
		7tmC_mGluR1	603..852	CDD:320565	114/252 (45%)
		TM helix 1	604..628	CDD:320565	7/23 (30%)
		TM helix 2	640..661	CDD:320565	9/20 (45%)
		TM helix 3	670..692	CDD:320565	10/21 (48%)
		TM helix 4	720..736	CDD:320565	5/15 (33%)
		TM helix 5	761..784	CDD:320565	7/22 (32%)
		TM helix 6	796..818	CDD:320565	18/21 (86%)
		TM helix 7	821..846	CDD:320565	10/26 (38%)
		GluR_Homer-bdg	1123..1172	CDD:402304
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920