Protein Alignment mGluR and grm3

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_031754896.1
• Gene: grm3 / 100492610
• XenbaseID: XB-GENE-977445
• Length: 878
• Species: Xenopus tropicalis
• Alignment Length: 944
• Identity: 457/944 - (48%)
• Similarity: 603/944 - (63%)
• Gaps: 89/944 - (9%)

  Fly     9 TILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGA-PCGPKVYNRGVQ 72
            |.|.|:::..:|:.|.|.  |:.|......:...||::||||||::|||.|. .||....:||:|
 Frog     3 TSLQVLLLALFSKAVLLS--SSDHNFVRKEIKFEGDLVLGGLFPINEKGGGMDECGRINEDRGIQ 65

  Fly    73 RLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSS 137
            ||||||:|||::|.|.::|||:.:|||||||||||||||.|||:||||||..:|.:.|.|.|||.
 Frog    66 RLEAMLFAIDQINRDSSLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSY 130

  Fly   138 PQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDT 202
             .:::| |..|:.|||||||||||:|||||||||||||:|.|||:..||||:|:|.||||||||.
 Frog   131 -AIQEN-SPLPIAGVIGGSYSSVSIQVANLLRLFHIPQISYASTSAKLSDKSRYDYFARTVPPDF 193

  Fly   203 FQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSII 267
            :|:.|:.:||:.|||:||||:.|||.|||.||||...||..||:|||.:|||..:...|.:|:.|
 Frog   194 YQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEHEARLRNICIATSEKVGRSNLKKSYDNAI 258

  Fly   268 SKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITV 332
            .:|.:||||:.||||.|::|.|.:|.||.|.|.|  |.||||||||.|:.:::|.|.||.||||:
 Frog   259 KELLQKPNAKVVVLFMRSDDTRELLAAANRFNAS--FTWIASDGWGAQESIVKGNEHIAYGAITL 321

  Fly   333 ELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAK 397
            ||.|..:.:||:|...|||..|.|||||.::|:..|.|.|      .:.:......|.::.:.:.
 Frog   322 ELASHPVKEFDKYFQSLTPYNNHRNPWFKDFWQQKFQCSL------QNKNQQVKFCDKRLNINSS 380

  Fly   398 TECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRC-NTQSDQTTETRKHLQSESVWY 461
                         .||||||..||::||||.|||||.:....| ||
 Frog   381 -------------NYEQESKIMFVINAVYAMAYALHQMQRTVCPNT------------------- 413

  Fly   462 RKISTDTKSQACPDMANYDGKEFYNNYLLNVSFI------DLAGSEVKFDRQGDGLARYDILNYQ 520
                    :..|..|...|||:.|.:|||.|:|.      ....|.||||..|||:..|::.|:
 Frog   414 --------NILCDAMKVLDGKKLYKDYLLKVNFTAPFIPPSNTDSIVKFDAYGDGIGLYNVFNF- 469

  Fly   521 RQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQ-GDTCCWICDSC 584
             |.::..|.|..||:|...|.|:.:.:.|:|.. .|||.||.||....:|..| ||.|||||..|
 Frog   470 -QYHNGKYSYLKIGQWAETLSLDVDIIQWSKSL-VPTSQCSDPCAPNEMKNMQPGDVCCWICIPC 532

  Fly   585 ESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFA 649
            |.:||:.|||||.|||.|.||.||..||:.|...|:||...:|:.|:.||..|...|.:|..:|.
 Frog   533 EKYEYLADEFTCIDCGEGRWPTADLTSCFDLPEDYIKWEDAWAIGPVTIACLGFVCTCLVGGVFI 597

  Fly   650 KNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTN 714
            ||:.||||:||||||.|.||.|:.:|||.||..||||:...|.|:|.|:|..|.:.|||||||||
 Frog   598 KNNSTPLVKASGRELCYILLIGVFMCYCMTFFFIAKPSPVICTLRRLGLGTSFVVCYSALLTKTN 662

  Fly   715 RISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFY-YPDRRE-VILK 777
            ||:|||......|||.|:|||:|||||..|||::|:::..:|:::|.||||.| .|::|| ||||
 Frog   663 RIARIFSGVKDGAQRPKFISPKSQVVICLSLISVQIVVVSVWLMLEFPGTRRYTLPEKRETVILK 727

  Fly   778 CKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGN 842
            |.::|.|.|.|..|:::|:.:||:||.||||.||||||:|||||||||||||||||:||::.|.:
 Frog   728 CNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSS 792

  Fly   843 SYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNV--RKLTMN-------STVYRRSAAA 898
            .|.|||||:|||:|||..|.|.||::|||:|::|.|.|||  .:|.:|       :|.|.:|:|
 Frog   793 DYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTATTYSQSSA- 856

  Fly   899 VAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSS 932
                   |:.|:.|      ...||.|..:.:||
 Frog   857 -------SAHYTPT------ICNGGEVLDSTTSS 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	244/510 (48%)
		NCD3G	556..605	CDD:462210	29/49 (59%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	144/252 (57%)
		TM helix 1	625..650	CDD:320600	8/24 (33%)
		TM helix 2	662..683	CDD:320600	12/20 (60%)
		TM helix 3	692..716	CDD:320600	14/23 (61%)
		TM helix 4	738..758	CDD:320600	9/19 (47%)
		TM helix 5	781..807	CDD:320600	11/25 (44%)
		TM helix 6	815..838	CDD:320600	20/22 (91%)
		TM helix 7	845..870	CDD:320600	15/24 (63%)
grm3	XP_031754896.1	PBP1_mGluR_groupII	31..492	CDD:380598	245/512 (48%)
		NCD3G	503..553	CDD:462210	29/49 (59%)
		7tmC_mGluR_group2	573..826	CDD:320411	144/252 (57%)
		TM helix 1	573..598	CDD:320411	8/24 (33%)
		TM helix 2	610..631	CDD:320411	12/20 (60%)
		TM helix 3	640..664	CDD:320411	14/23 (61%)
		TM helix 4	686..706	CDD:320411	9/19 (47%)
		TM helix 5	731..757	CDD:320411	11/25 (44%)
		TM helix 6	765..788	CDD:320411	20/22 (91%)
		TM helix 7	795..820	CDD:320411	15/24 (63%)