DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm8l

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017946013.2	Gene:	grm8l / 100489237	XenbaseID:	XB-GENE-953825	Length:	886	Species:	Xenopus tropicalis

Alignment Length:	915	Identity:	405/915 - (44%)
Similarity:	564/915 - (61%)	Gaps:	76/915 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQRLEA 76
            ::..|...|.|.:::.:..|     |:.:.|||.||||||||.|| .|.|||......||.||||
Frog     9 ILFFLLVQRSVGVQASTAQH-----SIKIDGDITLGGLFPVHAKGPAGTPCGEVKKEAGVHRLEA 68

  Fly    77 MLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLR 141
            ||||:|::|.||.:||.:|:|..||||||||||||.|||.||:|.:.. |||...|::|..|.|
Frog    69 MLYALDQINGDPELLPNLTLGARILDTCSRDTYALEQSLTFVQALIQK-DTSDIRCSNGDPPIL- 131

  Fly   142 KNASSGP--VFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQ 204
                |.|  |.||||.|.||||:.|||:||||.|||:|.||||..|||..|:|.|:|.||||::|
Frog   132 ----SRPERVVGVIGASASSVSIMVANVLRLFSIPQISYASTAPELSDNNRYDFFSRVVPPDSYQ 192

  Fly   205 SVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDKVFDSIIS 268
            :.|:|||:|...|:||||:.|||:|||.|:||..:.:.|. .||||.:.|:|.......||.:|.
Frog   193 AQAMVDIVKALGWNYVSTLASEGNYGESGVEAFMQISREAGGVCIAQSIKIPREPRPGEFDKVIR 257

  Fly   269 KLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVE 333
            :|.:.|||||:::|...:|.:|:|:|::|||.:..|.|:.||.||.:...:.|||::||||:|:.
Frog   258 RLLETPNARGIIIFANEDDIKRVLEASQRANQTGHFLWVGSDSWGSKTSPVLGLEEVAEGAVTIL 322

  Fly   334 LQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKT 398
            .:...|..||:|....|.|.|:||.||||:|||.|.|.||..:.:|:              ..:.
Frog   323 PKRASIEGFDQYFTSRTLENNRRNIWFAEFWEDDFKCRLTRSAARPE--------------DPRR 373

  Fly   399 ECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRK 463
            :|....|:::...||||.|.|||:|||||.|:||||:|.|.|...|.
Frog   374 KCTGGERIAKDSAYEQEGKVQFVIDAVYAMAHALHNMHVDLCPGHSG------------------ 420

  Fly   464 ISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGY 528
                    .|..|...:|: ....|:..|:|...||:.|.|:..||...||||..|| ..|.|..
Frog   421 --------VCDKMDPIEGR-LLLRYIHRVNFNGSAGTPVMFNENGDAPGRYDIFQYQ-MANDSAP 475

  Fly   529 QYKVIGKWFNGLQLNSETVVWN-KETEQPTSACSLPCEVGMIKKQ-QGDTCCWICDSCESFEYVY 591
            .|:|||:|...|:|:.|.:.|: .:::.|:|.|||||:.|..||. :|..|||.|:.|:.:::..
Frog   476 SYRVIGQWTEYLRLSIEEMQWSGGQSDIPSSVCSLPCQPGERKKMVKGVPCCWHCELCDGYQFQL 540

  Fly   592 DEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPL 656
            |:|||:.|...:.|..::.:|.|..|..::|.|.:|::|:.:||.||..|..|:....:.:|||:
Frog   541 DDFTCQLCPFDMRPNENRTACRATPIIKLEWTSAWAVLPLFLAIVGILSTLFVVGTLVRFNDTPI 605

  Fly   657 VRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFH 721
            ||||||||||.||.||.:.|..||.::.:|.:..|.|:|..:|:|..|.|:|||||||||.|||.
Frog   606 VRASGRELSYVLLTGIFLMYAITFLMMGEPGVAVCALRRLFLGLGMCISYAALLTKTNRIYRIFE 670

  Fly   722 SASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYY-------PDRREVILKCK 779
            ...:|....::|||.||:|||.|||.:|::.|.:|:.|.||.:...|       |:....:|||.
Frog   671 QGKRSVTPPRFISPASQLVITFSLIGVQLVGTSVWLAVLPPHSFIDYEEQRTPNPENARGVLKCD 735

  Fly   780 IQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSY 844
            :.|:|.:...:|:::|:..||:||:|.|.:||||||:|.||||||||||:|||||||:|||..|.
Frog   736 MSDLSLVSCLMYSILLMVTCTVYAVKARGVPENFNEAKPIGFTMYTTCIVWLAFVPIFFGTAQSA 800

  Fly   845 E---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTS 906
            |   :|||||.:|:||||||:|..||.||||:::|||::||:|       .:||..|||..|..|
Frog   801 EKIYIQTTTLTVSMSLSASVSLGMLYVPKVYVIIFHPEQNVQK-------RKRSFKAVATAATMS 858

  Fly   907 SGYSR 911
            :..|:
Frog   859 TRLSQ 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	227/502 (45%)
		ANF_receptor	72..518	CDD:279440	198/448 (44%)
		NCD3G	557..604	CDD:284890	20/47 (43%)
		7tm_3	638..873	CDD:278433	123/244 (50%)
grm8l	XP_017946013.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12003
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000