DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm5

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017947244.1	Gene:	grm5 / 100485273	XenbaseID:	XB-GENE-954112	Length:	1172	Species:	Xenopus tropicalis

Alignment Length:	976	Identity:	368/976 - (37%)
Similarity:	539/976 - (55%)	Gaps:	107/976 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNR 69
            :.||.:        |     :.:.:.|:.:..||. :.||||:|.||.||.:    |...||:.|
Frog    15 DGNGNV--------W-----IMASAQTNERRVVSY-MAGDIIIGALFSVHHQ----PTVDKVHER 61

  Fly    70 ---------GVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASL-NN 124
                     |:||:||||:|:||:|.|..:||.|::|..|.|:|.....||.||::|:|.|| ::
Frog    62 KCGEIREQYGIQRVEAMLHALDRINADQTLLPNISLGCEIRDSCWHTAVALEQSIEFIRDSLISS 126

  Fly   125 LDTSG-YECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDK 188
            .:..| ..|.||||...|   |..|:.||||...|||::||.|||:||:|||::.::|:..||||
Frog   127 EEEEGLVRCVDGSSAPSR---SKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDK 188

  Fly   189 TRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEK 253
            |.:..|.|.||.|..|:.|:|||:|.:||:|||.:|:||:|||.|:||....:.:..:|||.:.|
Frog   189 TLYKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGERGMEAFKDMSAKDGICIAHSYK 253

  Fly   254 VPSAADDKVFDSIISKLQKK-PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQK 317
            :.|.|.::.||.::.||:.. |.||.||.|......|.:|.|.||.|:...|..:.||||..:..
Frog   254 IYSNAGEQSFDKLLKKLRSHLPKARVVVCFCEGMTVRGLLMAMKRQNIIGEFLLLGSDGWADRYD 318

  Fly   318 LLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTS 382
            :.:|.:..|.|.||::|||..:..||.|.:||.||.|.|||||.|:|:..|.|.|...|   ..:
Frog   319 VTDGYQREAAGGITIKLQSPDVKWFDDYYLQLRPENNLRNPWFQEFWQHRFQCKLKGYS---QEN 380

  Fly   383 NSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQT 447
            ...|.|.|.             |:|.:..|.|:||..||::|:||.||.|||:....|...:.
Frog   381 QKYNRTCNS-------------RMSLRSQYVQDSKMGFVINAIYAMAYGLHNMQTVLCPGYAG-- 430

  Fly   448 TETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLA 512
                                    .|..|...||::..:: ::..:|..::|..:.||..||...
Frog   431 ------------------------LCDAMKPIDGQKLLDS-IMKANFTGVSGDMITFDENGDSPG 470

  Fly   513 RYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGD- 575
            ||:|:|:::. ....|.|..:|.|.||.....:..:|:.:.....|.||.||..|.||. ::|:
Frog   471 RYEIMNFKKM-GKDYYDYINVGSWDNGELKMDDDEIWSNKNLVIRSVCSDPCAKGQIKVIRKGEV 534

  Fly   576 TCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIAL 640
            :|||.|..|:..|.|:||:|||.|..|.||..|...|..:.:::::|:....:..:..:..|:..
Frog   535 SCCWTCTPCKDNEIVFDEYTCKACDLGSWPTDDLTGCDPIPVEFLRWSDPEPIAAVVFSCLGLLA 599

  Fly   641 TSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSII 705
            |..|:.:|....|||:|::|.|||.|.:|.||.:.|..||:|||||....|.|||.|||:..::.
Frog   600 TMFVMAIFILYRDTPVVKSSSRELCYIILAGICLGYLCTFSLIAKPQQIYCYLQRIGIGLSPAMS 664

  Fly   706 YSALLTKTNRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYY 768
            ||||:||||||:||...:.|.  .::.:::|..:|:||...||.||:.|.:...::|||...|.|
Frog   665 YSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFVLICIQLGIIVALFIMEPPDVIFDY 729

  Fly   769 PDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAF 833
            |..|||.|.|...::..:....||.:||..||.||.|||.:|.||||:|:|.|||||||||||||
Frog   730 PSIREVYLICNTNNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAF 794

  Fly   834 VPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYR----- 893
            |||||  |::|::  .|:|.|:||||:|||.|::.|||||::..|::|||.....|||.|
Frog   795 VPIYF--GSNYKI--ITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGD 855

  Fly   894 -RSAAAVAQGAPT--------SSG--YSRTHAPG-TSALTGGAVGTNASSSTLPTQN-----SPH 941
             :|::|.::.:..        |||  .|.:..|| |.:.....:|.:...|....||     |.|
Frog   856 GKSSSAASRSSSLVNLWKRRGSSGETLSISFTPGPTHSYCQQPIGISNGKSVTWAQNEKSSKSQH 920

  Fly   942 L 942
            |
Frog   921 L 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	191/510 (37%)
		ANF_receptor	72..518	CDD:279440	170/448 (38%)
		NCD3G	557..604	CDD:284890	23/48 (48%)
		7tm_3	638..873	CDD:278433	115/236 (49%)
grm5	XP_017947244.1	PBP1_mGluR_groupI	32..503	CDD:380597	193/522 (37%)
		NCD3G	514..564	CDD:369426	23/49 (47%)
		7tmC_mGluR5	584..833	CDD:320566	118/252 (47%)
		TM helix 1	584..609	CDD:320566	4/24 (17%)
		TM helix 2	621..642	CDD:320566	10/20 (50%)
		TM helix 3	651..675	CDD:320566	14/23 (61%)
		TM helix 4	699..719	CDD:320566	8/19 (42%)
		TM helix 5	742..768	CDD:320566	9/25 (36%)
		TM helix 6	776..799	CDD:320566	19/22 (86%)
		TM helix 7	802..827	CDD:320566	12/26 (46%)
		GluR_Homer-bdg	1122..1172	CDD:371160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920