DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm2

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_002935662.2	Gene:	grm2 / 100380092	XenbaseID:	XB-GENE-1012087	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	912	Identity:	441/912 - (48%)
Similarity:	580/912 - (63%)	Gaps:	95/912 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILD 102
            :.:.||.::|||||||||| .||.||....:||:|||||||:|:|.:||||::|||:.:|.||||
Frog    27 IRVDGDFVIGGLFPVHEKGAPGAECGRMNEHRGLQRLEAMLFALDAINNDPHLLPGLQLGAHILD 91

  Fly   103 TCSRDTYALNQSLQFVRASLNNLDTSGYECADGS------SPQLRKNASSGPVFGVIGGSYSSVS 161
            |||:|||||.|:|:.||.||...|...:.|.|||      ||.        .:.||||||||.||
Frog    92 TCSKDTYALEQALELVRGSLTRTDGPQHLCPDGSYAIHGESPT--------AISGVIGGSYSDVS 148

  Fly   162 LQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSE 226
            :|||||||||.|.|:|.|||:..||||:|:|.||||||||.:|:.|:.:||:.|||:||||:.||
Frog   149 IQVANLLRLFQIAQISYASTSAKLSDKSRYDFFARTVPPDFYQAKAMAEILRYFNWTYVSTVASE 213

  Fly   227 GSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRI 291
            |.|||.||||..:||..||:|||.:|||..:.:.|.|..:|..||:||:||.|||||:.||||.:
Frog   214 GDYGETGIEAFEQEARARNICIATSEKVGRSMNKKTFAGVIKALQQKPSARVVVLFTKIEDAREL 278

  Fly   292 LQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQR 356
            |.||:..|:|  |.|:||||||..:.::.|.|.:||||||:||.|..:.:|..|...|.|:.|.|
Frog   279 LAAAQELNVS--FTWVASDGWGALESVVLGSEQVAEGAITIELASYPLMEFSEYFQSLHPDNNTR 341

  Fly   357 NPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFV 421
            ||||.|:||:.|.|.|||    |..|                  :.|.|   :|.:|||||..||
Frog   342 NPWFREFWENKFQCSLTS----PGCS------------------EHSLR---QVKFEQESKIMFV 381

  Fly   422 VDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYN 486
            |:||||.|:||||:.:..|             |.|             :..||:|...:||.||.
Frog   382 VNAVYAMAHALHNMQHAVC-------------LNS-------------TYLCPNMNPPNGKRFYR 420

  Fly   487 NYLLNVSF------IDLAGSEVKFDRQGDGLARYDILNYQRQENSSG-YQYKVIGKWFNGLQLNS 544
            :|:|||.|      .| ..|.|:||:.|||:.||:|.|:|   |:.| |.|:.:|.|...|.||:
Frog   421 DYILNVKFNAPFPPPD-TKSTVRFDKYGDGIGRYNIFNFQ---NTGGRYHYQKVGYWAEELTLNT 481

  Fly   545 ETVVWNKETEQPTSACSLPCEVGMIKKQQ-GDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYAD 608
            ..:.|.| :..|.|.||.||:...:|..| ||.|||||.||:.:|::.|||||||||.|.||..|
Frog   482 SLIPWAK-SAVPVSQCSDPCKKNEVKSMQPGDVCCWICISCQPYEFLVDEFTCKDCGLGYWPNLD 545

  Fly   609 KLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGIL 673
            ...||.|..:|::|...:|:.|:.::..|:..|..||.:|.:|::||:|:||||||.|.||.|:|
Frog   546 LTGCYELPQEYIRWGDAWAVGPVCLSCLGLLSTLFVIGVFVQNNNTPIVKASGRELCYILLCGVL 610

  Fly   674 VCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQ 738
            :||..||..|:||:...|.|:|.|:|..|:|.|||||||||||:|||..|....||.::|||.||
Frog   611 LCYAMTFIFISKPSTSVCTLRRLGLGTSFAICYSALLTKTNRIARIFSGARDGVQRPRFISPASQ 675

  Fly   739 VVITTSLIAIQVLITMIWMVVEPPGTR-FYYPDRREVI-LKCKIQDMSFLFSQLYNMILITICTI 801
            |.|...||:.|:|:.:||::.|||||| ...||:|.:: |||...|.|.|.|..||::|:.:||:
Frog   676 VGICLVLISCQLLVVLIWLLFEPPGTRKDTAPDKRYIVTLKCNSGDGSMLISLSYNVLLVLLCTL 740

  Fly   802 YAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCL 866
            ||.||||.||||||:|||||||||||||||||:|||:.|.:.|.|||||||:|:|||.||.|.||
Frog   741 YAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIYYVTSSDYRVQTTTLCVSVSLSGSVVLGCL 805

  Fly   867 YSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASS 931
            ::||::|::|.|.|||       |.:|     :|....:::|...||......:.....|.....
Frog   806 FTPKLHIIIFQPQKNV-------TSHR-----IATNRFSATGPGGTHGSAVQYVPTVCNGREVVD 858

  Fly   932 ST 933
            ||
Frog   859 ST 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	247/512 (48%)
		ANF_receptor	72..518	CDD:279440	220/457 (48%)
		NCD3G	557..604	CDD:284890	27/47 (57%)
		7tm_3	638..873	CDD:278433	136/236 (58%)
grm2	XP_002935662.2	Periplasmic_Binding_Protein_type1	27..479	CDD:385651	247/516 (48%)
		NCD3G	492..542	CDD:369426	28/49 (57%)
		7tmC_mGluR2	562..815	CDD:320563	140/252 (56%)
		TM helix 1	562..587	CDD:320563	7/24 (29%)
		TM helix 2	599..620	CDD:320563	12/20 (60%)
		TM helix 3	629..653	CDD:320563	15/23 (65%)
		TM helix 4	675..695	CDD:320563	9/19 (47%)
		TM helix 5	720..746	CDD:320563	12/25 (48%)
		TM helix 6	754..777	CDD:320563	20/22 (91%)
		TM helix 7	784..809	CDD:320563	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	405	1.000	Domainoid score	I703
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	844	1.000	Inparanoid score	I437
OMA	1	1.010	-	-		QHG49358
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0003689
OrthoInspector	1	1.000	-	-		otm47899
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.980