DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm5b

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001289167.1	Gene:	grm5b / 100332913	ZFINID:	ZDB-GENE-090821-6	Length:	1195	Species:	Danio rerio

Alignment Length:	1020	Identity:	373/1020 - (36%)
Similarity:	552/1020 - (54%)	Gaps:	118/1020 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNR----- 69
            ||..:.:|.| |:..|.|.:.:: :..|...:|||||:|.||.||.:    |...||:.|
Zfish     3 ILCSLALLLW-RMTSLVSTAQSN-ERRVVAHIPGDIIIGALFSVHHQ----PPADKVHERKCGAV 61

  Fly    70 ----GVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTS-- 128
                |:||:|||::.:||:|.||.|||.:|:|..|.|:|.....||.||::|:|.||...|.|
Zfish    62 REQYGIQRVEAMMHTLDRINADPKILPNVTLGCEIRDSCWHSAVALEQSIEFIRDSLVAADESEE 126

  Fly   129 ---GYECAD-GSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKT 189
               |.:||| |::|...|.    |:.|:||...|||::||.|||:||:|||::.::|:..||||:
Zfish   127 AGGGAKCADPGATPMKGKK----PIVGLIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKS 187

  Fly   190 RFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKV 254
            .:..|.|.||.|..|:.|:|||:|.:||:|||.||:||:|||.|:||..:.|.:..:|||.::|:
Zfish   188 LYKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAIHTEGNYGESGMEAFKEMAGKEGICIAHSDKI 252

  Fly   255 PSAADDKVFDSIISKLQK-KPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKL 318
            .|.|.::.||.::.||:| .|.||.|..|......|.||.|.:|.||...|..:.||||..:..:
Zfish   253 WSNAGEQNFDRLLVKLRKYLPKARVVACFCEGMTVRNILMAMRRQNLVGEFLLVGSDGWADRYDV 317

  Fly   319 LEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSN 383
            .:|....|.|.||::|||..:..||.|.::|.||.|.|||||.|:|:..|:|   .|......::
Zfish   318 TDGYVREAAGGITIKLQSADVKWFDDYYLKLRPENNMRNPWFPEFWQHRFHC---RLKGHAQENH 379

  Fly   384 SANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTT 448
            ..|.|..|         .||.|..    |.|::|..||::|:|:.|:.||::....|
Zfish   380 KYNRTCGK---------RDSLRQQ----YAQDTKMGFVINAIYSMAHGLHSMQKSLC-------- 423

  Fly   449 ETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLAR 513
                              ......|..|...||.:.. .:|:..:|..:.|..:.||..||....
Zfish   424 ------------------PGVVGLCDAMRPIDGSKLL-EFLMKTNFSGVTGEHIYFDENGDSPGS 469

  Fly   514 YDILNYQRQENSSGYQYKVIGKWFN-GLQLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGD- 575
            |.|:|:::. ....:.|..:|.|.| |||::.:. :|..:.:...|.||.||:.|.||. ::|:
Zfish   470 YVIMNFKKM-GKDYFDYTNVGSWDNSGLQIDDDE-IWPSKEDIIKSVCSEPCDKGQIKVIRKGEV 532

  Fly   576 TCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIAL 640
            :|||.|..|:..|:|:||:||:.|..|.||..|.:.|..:.::|::|.....:..:..:..|:..
Zfish   533 SCCWTCTPCKDNEFVFDEYTCRACELGSWPTDDLIGCDPIPVKYLRWGDPEPIAAVVFSCLGLMA 597

  Fly   641 TSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSII 705
            |..|:.:|....|||:|::|.|||.|.:|.||.:.|..||.|||||.:..|.|||.|||:..::.
Zfish   598 TFFVMSIFIIYRDTPVVKSSSRELCYIILVGICLGYLCTFCLIAKPHVIYCYLQRLGIGLSPAMS 662

  Fly   706 YSALLTKTNRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYY 768
            ||||:||||||:||...:.|.  .::.:::|..:|:||...||.:|:.|.:...|:|||.....|
Zfish   663 YSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFLLILLQLGIIVALFVMEPPDVIHDY 727

  Fly   769 PDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAF 833
            |..|||.|.|...::..:....||.:||..||.||.|||.:|.||||:|:|.|||||||||||||
Zfish   728 PSIREVNLICNTTNLGVVAPLGYNGLLIMSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAF 792

  Fly   834 VPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYR----- 893
            ||||||:    ..:|.|:|.|:||||:|||.|::.|||||::..|::|||.....|||.|
Zfish   793 VPIYFGS----NYKTITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMHVGD 853

  Fly   894 -RSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHL---------DEASAQ 948
             :|::|.::.:...:.:.|..:.|.:..:.|...|.|.:..  :....||         ...|.|
Zfish   854 GKSSSAASRSSSLVNLWKRRGSSGETLSSNGKSVTWAQNEC--SSKGTHLWQRLSFHIKKRESNQ 916

  Fly   949 TNV-------------------AHKTNGEFLPEVGERVE--PICH 972
            |.|                   ...:|.:.|.||.|..|  ||.:
Zfish   917 TAVIKPFSKTSEGRYCGGSDINTDNSNNKMLYEVTEAEERYPITY 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	188/515 (37%)
		ANF_receptor	72..518	CDD:279440	167/452 (37%)
		NCD3G	557..604	CDD:284890	22/48 (46%)
		7tm_3	638..873	CDD:278433	114/236 (48%)
grm5b	NP_001289167.1	PBP1_mGluR_groupI	27..501	CDD:107369	191/525 (36%)
		ANF_receptor	68..476	CDD:279440	168/454 (37%)
		NCD3G	513..561	CDD:284890	22/47 (47%)
		7tm_3	595..828	CDD:278433	114/236 (48%)
		GluR_Homer-bdg	1144..1195	CDD:287563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920