DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Tas1r2

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001258195.1	Gene:	Tas1r2 / 100270683	-ID:	-	Length:	843	Species:	Rattus norvegicus

Alignment Length:	903	Identity:	219/903 - (24%)
Similarity:	387/903 - (42%)	Gaps:	170/903 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LPGDIILGGLFPVHEKGEG---------APCGP---KVYNRGVQRLEAMLYAIDRVNNDPNILPG 93
            |.||.:|||||.:|...:.         ..|..   ||.  |...::||.:|::.:||..::|||
  Rat    32 LAGDYLLGGLFTLHANVKSISHLSYLQVPKCNEFTMKVL--GYNLMQAMRFAVEEINNCSSLLPG 94

  Fly    94 ITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECA--DGSSPQLRKNASSGP-VFGVIGG 155
            :.:|..::|.|...               ||:....|..|  |...|.|:..:...| |..|||.
  Rat    95 VLLGYEMVDVCYLS---------------NNIHPGLYFLAQDDDLLPILKDYSQYMPHVVAVIGP 144

  Fly   156 SYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYV 220
            ..|..::.|:|:|..|.|||::.::.:..|.||..|....||||..|....|:|.::.:|.|:::
  Rat   145 DNSESAITVSNILSHFLIPQITYSAISDKLRDKRHFPSMLRTVPSATHHIEAMVQLMVHFQWNWI 209

  Fly   221 STIHSEGSYGEYGIEALHKEATE-RNVCIAVAEKVP--------SAADDKVFDSIISKLQKKPNA 276
            ..:.|:..||......|.:..|: .::|||..|.:|        .:.:.:..|:|:.|| ::.:|
  Rat   210 VVLVSDDDYGRENSHLLSQRLTKTSDICIAFQEVLPIPESSQVMRSEEQRQLDNILDKL-RRTSA 273

  Fly   277 RGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGA--ITVELQSEII 339
            |.||:|:.............|.|.: .|.||||:.|. ...:|..|.::....  :.|.:|...|
  Rat   274 RVVVVFSPELSLYSFFHEVLRWNFT-GFVWIASESWA-IDPVLHNLTELRHTGTFLGVTIQRVSI 336

  Fly   340 ADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSY 404
            ..|.::.::      :..|.:.                .|:|:| ..:|.|:       :||...
  Rat   337 PGFSQFRVR------RDKPGYP----------------VPNTTN-LRTTCNQ-------DCDACL 371

  Fly   405 RLS-----------EKVGYEQESKTQFVVDAVYAFAYALHNL---HNDRCNTQSDQTTETRKHLQ 455
            ..:           |:|.|.       |..||||.|:|||.|   :..||..|.....:..:
  Rat   372 NTTKSFNNILILSGERVVYS-------VYSAVYAVAHALHRLLGCNRVRCTKQKVYPWQLLR--- 426

  Fly   456 SESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQ 520
              .:|:                              |:| .|.|:.:.||:|||.....||:.:|
  Rat   427 --EIWH------------------------------VNF-TLLGNRLFFDQQGDMPMLLDIIQWQ 458

  Fly   521 RQENSSGYQ----YKVIGKWFNGLQLNSETVVW-NKETEQPTSACSLPCEVGMIKKQQG-DTCCW 579
            ...:.:.:|    |....|....:    ..|.| ......|.|.||..|:.|.:||..| ..||:
  Rat   459 WDLSQNPFQSIASYSPTSKRLTYI----NNVSWYTPNNTVPVSMCSKSCQPGQMKKSVGLHPCCF 519

  Fly   580 ICDSCESFEYV---YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALT 641
            .|..|....|:   .|||.|..|...:|.|.:.::|:.....:::|:.:..::...:|..|...|
  Rat   520 ECLDCMPGTYLNRSADEFNCLSCPGSMWSYKNDITCFQRRPTFLEWHEVPTIVVAILAALGFFST 584

  Fly   642 SIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIY 706
            ..::.:|.::..||:||::|..:.:.:|..:|:.:......:..||:.||..::....|.|||..
  Rat   585 LAILFIFWRHFQTPMVRSAGGPMCFLMLVPLLLAFGMVPVYVGPPTVFSCFCRQAFFTVCFSICL 649

  Fly   707 SALLTKTNRISRIFHSASKSAQRL--------KYISPQSQVVITTSLIAIQVLITMIWMVVEPPG 763
            |.:..::.:|..:|    |.|:||        :|..|...|...|::....|:..|:...:.|.|
  Rat   650 SCITVRSFQIVCVF----KMARRLPSAYSFWMRYHGPYVFVAFITAIKVALVVGNMLATTINPIG 710

  Fly   764 TRFYYPDRREVILKCKIQDMS-FLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTM---Y 824
             |....|...:||.|.....: .||:...:::|..:...:|...:::|.|:||:|||..:|   :
  Rat   711 -RTDPDDPNIMILSCHPNYRNGLLFNTSMDLLLSVLGFSFAYMGKELPTNYNEAKFITLSMTFSF 774

  Fly   825 TTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVAL-VCLYSPKVYILVFHPDKN 881
            |:.|....|:.::.|      |..|.:.:.:::...:|: :..:.||.|:::|:|::|
  Rat   775 TSSISLCTFMSVHDG------VLVTIMDLLVTVLNFLAIGLGYFGPKCYMILFYPERN 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	129/542 (24%)
		ANF_receptor	72..518	CDD:279440	113/473 (24%)
		NCD3G	557..604	CDD:284890	18/50 (36%)
		7tm_3	638..873	CDD:278433	58/247 (23%)
Tas1r2	NP_001258195.1	Periplasmic_Binding_Protein_Type_1	30..484	CDD:299141	130/548 (24%)
		ANF_receptor	73..460	CDD:279440	114/477 (24%)
		NCD3G	496..547	CDD:284890	18/50 (36%)
		7tm_3	581..818	CDD:278433	58/247 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000