Protein Alignment mGluR and grm1b

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001289181.3
• Gene: grm1b / 100150246
• ZFINID: ZDB-GENE-090821-3
• Length: 1158
• Species: Danio rerio
• Alignment Length: 979
• Identity: 369/979 - (37%)
• Similarity: 552/979 - (56%)
• Gaps: 104/979 - (10%)

  Fly    41 LPGDIILGGLFPVH-----EKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHI 100
            :.||||:|.||.||     ||.....||......|:||:|||.|.:||:|:||.:||.||:|..|
Zfish    41 MDGDIIIGALFSVHHQPSAEKVAERKCGEIREQYGIQRVEAMFYTLDRINSDPYLLPNITLGCEI 105

  Fly   101 LDTCSRDTYALNQSLQFVRASLNNL--DTSGYE-CADGSSPQLRKNASSGPVFGVIGGSYSSVSL 162
            .|:|...:.||.||::|:|.||.::  :..|.: |.:| :|..:..|:..|:.||||...|||::
Zfish   106 RDSCWHSSVALEQSIEFIRDSLISIRDEREGPKWCVEG-NPSAQPPATKKPIAGVIGPGSSSVAI 169

  Fly   163 QVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEG 227
            ||.|||:||:|||::.::|:..|||||.:..|.|.||.||.|:.||:||:|.:||:|||.:|:||
Zfish   170 QVQNLLQLFNIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARALLDIVKRYNWTYVSAVHTEG 234

  Fly   228 SYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKK-PNARGVVLFTRAEDARRI 291
            :|||.|:||..:.|::..:|||.::|:.|.|.:|.||.::.||::: |.||.||.|......|.:
Zfish   235 NYGESGMEAFKELASQEGLCIAHSDKIYSNAGEKHFDRLLRKLRERLPKARVVVCFCEGMTVRGL 299

  Fly   292 LQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQR 356
            |.|.:|..::..|..|.||||..:.:::||.|:.|.|.|||:||:|.:..|:.|.::|...||.|
Zfish   300 LMAMRRLGVAGEFLLIGSDGWADRDEVVEGYEEEAVGGITVKLQTEEVTSFNDYFLKLRLATNNR 364

  Fly   357 NPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFV 421
            ||||||:|:..|.|.|..     ....:.|...|..|.::..:           .|.|:||..||
Zfish   365 NPWFAEFWQHRFQCRLVG-----HPQENTNYRKNCSGYESLED-----------NYVQDSKMGFV 413

  Fly   422 VDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYN 486
            ::|:||.|:.||::|...|          ..|:                ..|.:|...||.:..
Zfish   414 INAIYAMAHGLHDMHEHLC----------PGHV----------------GLCEEMDPIDGSKLL- 451

  Fly   487 NYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNK 551
            ::||..||..::|.:|.||..||...||||:|.|..| ...:.|..:|.|..|:....:.::...
Zfish   452 DFLLKTSFAGVSGEDVWFDENGDSPGRYDIMNLQYVE-PGVFDYINVGSWHEGILSIDDYMIQMN 515

  Fly   552 ETEQPTSACSLPCEVGMIKK-QQGD-TCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYA 614
            .:|...|.||.||..|.||. ::|: :|||||..|:..|||.||||||.|..|.||..:...|..
Zfish   516 RSEMVRSVCSEPCSKGEIKVIRKGEVSCCWICTPCKDNEYVQDEFTCKACELGWWPDEELQVCEP 580

  Fly   615 LDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNT 679
            |.:::::|:...::..:..:..||.:||.|.::|....|||:|::|.|||.|.:|.||.:.|...
Zfish   581 LPLRHLEWSHPESIAAVVFSCLGILVTSFVTLVFILYRDTPVVKSSSRELCYIILAGIFLGYICP 645

  Fly   680 FALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKS--AQRLKYISPQSQVVIT 742
            |.|||:|:|.||.|||..:|:..|:.||||:||||||:||...:.|.  .::.:::|..:||||.
Zfish   646 FTLIARPSIASCYLQRLLVGLSASMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVVIA 710

  Fly   743 TSLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTR 807
            ..||::|:.:.:..:::|||.....||..|||.|.|...:|..:....||.:||..||.||.|||
Zfish   711 FILISMQLTLEVTLIILEPPEPIKSYPSIREVFLICNTSNMGMVAPLGYNGLLILSCTYYAFKTR 775

  Fly   808 KIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVY 872
            .:|.||||:|:|.||||||||||||||||||  |::|::.||:  .|:|||.:|||.|:::||:|
Zfish   776 NVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--GSNYKIITTS--FSVSLSVTVALGCMFTPKMY 836

  Fly   873 ILVFHPDKNVRKLTMNSTVYR----------RSAAAV--------AQGAPTSSGYSRTHA-PGTS 918
            |::..|::|||.....|.|.|          ||.:.:        |.|...|:|.|.:.: ||:.
Zfish   837 IIIAKPERNVRSAFTTSDVVRMHVGDGKIACRSNSLLNMFKRKKNASGNANSNGKSVSWSEPGSR 901

  Fly   919 ALTGG--------------AVGTNASSSTLP---TQNSPHLDEASAQTNVAHKTNGEFLPEVGER 966
            ....|              ..|:|.::...|   |.|:|.::.:...|...:....|      :.
Zfish   902 HPPKGEHMWHRLSVHVKKQEAGSNQTAIIKPLTNTYNNPGMEFSDLSTKTLYNVAEE------DE 960

  Fly   967 VEPI 970
            ::||
Zfish   961 IDPI 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	194/509 (38%)
		NCD3G	556..605	CDD:462210	26/50 (52%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	116/252 (46%)
		TM helix 1	625..650	CDD:320600	6/24 (25%)
		TM helix 2	662..683	CDD:320600	9/20 (45%)
		TM helix 3	692..716	CDD:320600	13/23 (57%)
		TM helix 4	738..758	CDD:320600	7/19 (37%)
		TM helix 5	781..807	CDD:320600	10/25 (40%)
		TM helix 6	815..838	CDD:320600	19/22 (86%)
		TM helix 7	845..870	CDD:320600	10/24 (42%)
grm1b	NP_001289181.3	None