DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and olfcg4

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001122034.1	Gene:	olfcg4 / 100148438	ZFINID:	ZDB-GENE-060503-66	Length:	835	Species:	Danio rerio

Alignment Length:	902	Identity:	239/902 - (26%)
Similarity:	409/902 - (45%)	Gaps:	157/902 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VSLPGDIILGGLFPVH-----------EKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILP 92
            :|..|||.:|.|||:|           .|.:...|. .|..|..:..|.|::||:.:|...::||
Zfish    34 ISKNGDITIGALFPIHSTETLTSLKFTRKPQPISCS-SVNLRDFRLAEIMIFAIEEINKSESLLP 97

  Fly    93 GITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSY 157
            .:|||..:.|||       ...|..:.|.:..:::.|::..||...|.       |:..:||.|.
Zfish    98 NVTIGYQVYDTC-------GSRLSTMSAIMGLMNSQGFDAEDGCKGQT-------PIQAIIGDSE 148

  Fly   158 SSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVST 222
            ||.::.:......|.||.:|.:::.:.||::..:..|.||...|..||.|||.|:|:..|:::..
Zfish   149 SSATVILTRTTGPFKIPVISHSASCECLSNRNDYPSFFRTTASDYHQSRALVHIVKHLGWTWLGA 213

  Fly   223 IHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAED 287
            :.|:..||.||:....|.|.|..:|:..:.|......:|:  ..:.:..||..|:.:|.|....:
Zfish   214 VSSDNDYGNYGMSIFQKIAQEEGICMEYSVKFYRTEQEKL--QKVVETMKKGTAKVIVAFVSFLE 276

  Fly   288 ARRILQAAKRANLS--QPF---HWIASD---------------GWGKQQKLLEGLEDIAEGAITV 332
            ...::......|::  |..   .||.|:               |:..::..:||..|.|
Zfish   277 MGLLIDQLSVQNITGLQMIGVKSWITSENYITPKSFHVLGGSLGFAMRKMYIEGFSDFA------ 335

  Fly   333 ELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANST---DNKIGV 394
                                       ...:||..|.|..|    ||:.||.|:|.   ::.:.:
Zfish   336 ---------------------------LKTFWEKHFQCSQT----KPNASNYASSCSRYNDLLML 369

  Fly   395 KAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNL--HNDRCNTQSDQTTETRKHLQSE 457
            |...|....:|.|..| ||          ||||.||:||:|  ..:|...:...|.:.::.:::
Zfish   370 KNYKEDVTEHRYSSNV-YE----------AVYAVAYSLHSLLKCKERVKCEKGMTIQPQQVVEA- 422

  Fly   458 SVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQ 522
                                           |..|:|....|..|.||..|..:|:|:::|:||.
Zfish   423 -------------------------------LKKVNFSVKFGDRVWFDSTGSTVAQYEVVNWQRI 456

  Fly   523 ENSSGYQYKVIGKWFNGLQ------LNSETVVW-NKETEQPTSACSLPCEVGMIK-KQQG-DTCC 578
            .:.| :|:|.:|.:...|.      ||:|.::| ....|:|.|.||..|..|..| .|:| ..||
Zfish   457 SDES-FQFKTVGYYDASLPPNQRFLLNTENIIWAGGMLEKPRSVCSESCPPGTRKASQKGRPACC 520

  Fly   579 WICDSCESFEYV--YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALT 641
            :.|..|...|..  .|...||.|....|....|..|....::::.:..:..::.:.:::||:.||
Zfish   521 YDCIPCAEGEISTDTDSNNCKQCPGEYWSNDKKNKCVLKAVEFLSFTEVMGVLLLFVSLFGVGLT 585

  Fly   642 SIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIY 706
            ::|.:||....|||:|||:..|||:.|||.:::|:..:...|.:||..||:|:....|:.|.:..
Zfish   586 TLVAILFYNKKDTPIVRANNSELSFLLLFSLILCFLCSITFIGRPTEWSCMLRHTAFGITFVLCI 650

  Fly   707 SALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPP----GTRFY 767
            |.:|.||..:...|.:....:..:|:..|..|.:.......|||:|.::|:.:.||    ..::|
Zfish   651 SCVLGKTIVVLMAFKATHPGSNVMKWFGPVQQRLSVLVFTFIQVIICVLWLTISPPFPYRNMKYY 715

  Fly   768 YPDRREVILKCKIQDMSFLFSQL-YNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWL 831
               :.::||:|.:..:...::.| |..:|..:|.|.|...||:|:||||:|||.|:|...|.:|:
Zfish   716 ---KEKIILECSLGSIVGFWAVLGYIGLLAALCFILAFLARKLPDNFNEAKFITFSMLIFCAVWI 777

  Fly   832 AFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFHPDKNVRKLTM 887
            .|:|.||.:.....|......|   |::|:.|: |:::||.||::..|::|.::..|
Zfish   778 TFIPAYFSSPGKLTVAVEIFAI---LASSIGLLFCIFAPKCYIILCKPEQNTKQHIM 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	128/540 (24%)
		ANF_receptor	72..518	CDD:279440	108/470 (23%)
		NCD3G	557..604	CDD:284890	17/50 (34%)
		7tm_3	638..873	CDD:278433	77/240 (32%)
olfcg4	NP_001122034.1	Periplasmic_Binding_Protein_Type_1	36..488	CDD:299141	131/549 (24%)
		ANF_receptor	77..454	CDD:279440	109/472 (23%)
		NCD3G	497..548	CDD:284890	17/50 (34%)
		7tm_3	584..817	CDD:278433	77/238 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910