DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vmn2r2

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_030108190.1	Gene:	Vmn2r2 / 100125586	MGIID:	3757666	Length:	911	Species:	Mus musculus

Alignment Length:	994	Identity:	261/994 - (26%)
Similarity:	450/994 - (45%)	Gaps:	149/994 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILVVVMVLSWSRVVDLKSPSNTHTQDSVS------VSLPG-------DIILGGLFPVHEK----- 56
            :::.:.|..|   |:|      |.|::|:      .:|.|       .:::|||||:|.:
Mouse     8 LILGLTVFLW---VEL------HAQENVTCKLLRKFNLSGYVEAENHSMVIGGLFPIHSRTIPTN 63

  Fly    57 -GEGAPCGPKV-----YN-RGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQS 114
             .:..|.|.::     :| ||.:.::.|::.|..:|...:|||..|:|..|.|||...:.|:..:
Mouse    64 NSDEVPVGSQMLFLSRFNFRGFRWMKTMIHTIKEINERKDILPNHTLGYQIFDTCFSVSKAMETA 128

  Fly   115 LQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPA 179
            |.|:.....|            .|..| |::...:.|:||...||:|:..|.:|.|::||||...
Mouse   129 LAFLTGQEEN------------KPNFR-NSTGKYLVGIIGAGGSSLSVAAARILGLYYIPQVGYT 180

  Fly   180 STAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER 244
            |:...|||..:|..|.|:.|.|.|||..:|.::::|.|.:|.||.|:..||:||:::|.:.....
Mouse   181 SSCAVLSDTFQFPSFYRSTPSDKFQSEGMVSLIQHFGWVWVGTIASDDDYGKYGVKSLRERMEFV 245

  Fly   245 NVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIAS 309
            |:|:|.:|.:|....::.....| |..|...|:.:|||:...|....:......|::.. .||||
Mouse   246 NLCVAFSETIPKVYSNEKMQKAI-KAIKSSTAKVIVLFSTDIDLGPFVLEVIHHNITDR-TWIAS 308

  Fly   310 DGWGKQQKLLEGLEDIAE--------GAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWED 366
            :.|     :...|  ||:        |.|...:...:|.....::..:.|..|..:....|:|:.
Mouse   309 EAW-----ITSAL--IAKPEYFPYFGGTIGFAIPRSVIPGLKEFLYDVHPSKNPNDVLTIEFWQT 366

  Fly   367 TFNCVLTSLSVKPDTSNSANST--DNKIGVKAKTECDDSYRLSE-KVGYEQESK---TQFVVDAV 425
            .|||...:.||..:..:..|.|  ::::...:...|....:|.: |..|...|:   |..|..||
Mouse   367 AFNCTWPNSSVPYNVDHRVNMTGKEDRLYDMSDQLCTGEEKLEDLKNTYLDTSQLRITNNVKQAV 431

  Fly   426 YAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLL 490
            |..||||..|  ..|:...:|..:|                     ||..:.:::.||.. .|..
Mouse   432 YLMAYALDRL--STCDLLEEQRNDT---------------------ACSHIPDFEPKELM-TYFK 472

  Fly   491 NVSFIDLAGSEVKFDRQGD-GLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVV------ 548
            .:..|...|:|::.|..|| |...|||||: ...|:....:..:|: :......||.|:
Mouse   473 KLKIITHDGAEIELDLNGDVGKGYYDILNW-HMGNTGEITFVKVGE-YKYTSTKSELVLPKNSSL 535

  Fly   549 -WNKETEQ-PTSACSLPCEVGMIK--KQQGDTCCWICDSCESFEYVYD---EFTCKDCGPGLWPY 606
             ||.|:.. |.|.|:..|..|..:  :|....||:.|..|.. .||.:   :..|..||...|..
Mouse   536 FWNTESSMLPESVCTKLCAPGTRRGIRQGQPVCCFNCIPCAD-GYVSEKSGQRECDPCGEDDWSN 599

  Fly   607 ADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFG 671
            |:|..|....::::.:........:.::|||..:...|.|::..:..||||:|:.||||:.:...
Mouse   600 AEKSKCVPKLVEFLAYGEALGFTLVILSIFGALVVLAVTVVYVIHRHTPLVKANDRELSFLIQMS 664

  Fly   672 ILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIF-HSASKSAQRLKYISP 735
            :::...::...|.||...||:.::..:.:||.:..|::|.||  ||..| :..|.|..||..:.|
Mouse   665 LVITVLSSLLFIGKPCNWSCMARQITLALGFCLCLSSILGKT--ISLFFAYRISVSKTRLISMHP 727

  Fly   736 QSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYP---DRREVILKCKIQDMSFLFSQL-YNMILI 796
            ..:.:|....:..::.:...::|:|||  |.:..   ...::|.:|....:.||.|.. ::::|.
Mouse   728 IFRKLIVLVCVVGEIGVCAAYLVLEPP--RMFKNIEIQNVKIIFECNEGSVEFLCSIFGFDVLLA 790

  Fly   797 TICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASV 861
            .:|.:.....|::|:|:.|.|.|.|.|....|:|::|||.|..|...::|......|   |::|.
Mouse   791 LLCFLTTFVARQLPDNYYEGKCITFGMLVFFIVWISFVPAYLSTKGKFKVAVEIFAI---LASSY 852

  Fly   862 ALV-CLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAV 925
            .|: ||:.||.:|::..|.:|.     :.||..|        .||        ...:..||..:|
Mouse   853 GLLGCLFLPKCFIILLRPKRNT-----DETVGGR--------VPT--------VDRSIQLTSASV 896

  Fly   926 GTNASSSTLPTQNSPHLDE 944
            .:..:|:|:.|.    |||
Mouse   897 SSELNSTTVSTV----LDE 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	141/532 (27%)
		ANF_receptor	72..518	CDD:279440	125/460 (27%)
		NCD3G	557..604	CDD:284890	14/51 (27%)
		7tm_3	638..873	CDD:278433	67/240 (28%)
Vmn2r2	XP_030108190.1	PBP1_CaSR	48..537	CDD:380587	143/536 (27%)
		NCD3G	545..598	CDD:369426	15/53 (28%)
		7tmC_V2R-like	618..870	CDD:320407	71/258 (28%)
		TM helix 1	619..643	CDD:320407	5/23 (22%)
		TM helix 2	655..676	CDD:320407	4/20 (20%)
		TM helix 3	685..707	CDD:320407	6/23 (26%)
		TM helix 4	732..748	CDD:320407	1/15 (7%)
		TM helix 5	775..798	CDD:320407	5/22 (23%)
		TM helix 6	807..832	CDD:320407	10/24 (42%)
		TM helix 7	837..862	CDD:320407	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910