Protein Alignment mGluR and LOC100007225

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_073785873.1
• Gene: LOC100007225 / 100007225
• -ID: -
• Length: 834
• Species: Danio rerio
• Alignment Length: 891
• Identity: 233/891 - (26%)
• Similarity: 411/891 - (46%)
• Gaps: 128/891 - (14%)

  Fly    39 VSLPGDIILGGLFPVH-----------EKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILP 92
            :|..||:.:|.:|.||           :|.:...|. .|..|..:.::.|:|||:.:|....:||
Zfish    33 LSKDGDVNIGAIFSVHSTEILTSFTYTQKPQLLSCS-SVSLRDFRMVQTMIYAIEEINRSLGLLP 96

  Fly    93 GITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSY 157
            .||:|..|.|.|.....|::.::    |.:|..:.:..:...|.|          |:..:||.:.
Zfish    97 NITVGYQIYDACGSRLSAMSATM----ALMNGPEFTWRDRCTGQS----------PIHAIIGETE 147

  Fly   158 SSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVST 222
            ||.::.::.....|.||.:||::|.:.||::..:..|.||:..|..||.||..|:|:|.||:|..
Zfish   148 SSATVILSRTTGPFKIPVISPSATCECLSNRKEYPSFFRTIASDYHQSRALAYIVKHFGWSWVGA 212

  Fly   223 IHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAED 287
            ::::..||..|:......|.|..:|:..:.|......:|: ..::..: ||..|:.:|.|..:.:
Zfish   213 VNTDNDYGNNGMTTFLNTAQEEGICVEYSVKFYRTEPEKL-QKVVETI-KKGTAKVIVAFLTSSE 275

  Fly   288 ARRILQAAKRANLSQPFHWIASDGWGKQQKLL-EGLEDIAEGAITVELQSEIIADFDRYMMQLTP 351
            ...:|:.....|:: ....|..:||...:.|: .....:..|::...::...|..|..|:::
Zfish   276 MYNLLEQLSIQNIT-GLQMIGVEGWITAKSLITPNSFHVLGGSLGFAVRKTAIEGFADYVIK--- 336

  Fly   352 ETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKI--GVKAKTECDDSYRLSEKVGYEQ 414
                      .:||..|.|.:|          ..||:...:  |:........:|  :|.|. ||
Zfish   337 ----------SFWETAFPCTMT----------IGNSSQYSLSCGIYQDLLLLKNY--NEDVP-EQ 378

  Fly   415 ESKTQFVVDAVYAFAYALHNL---HNDRCN----TQSDQTTETRKHLQSESVWYRKISTDTKSQA 472
            ...|. |..||||.|::||:|   ..|.|.    .|..|.....|.:
Zfish   379 RYSTN-VYKAVYAVAHSLHSLLKCKEDGCKKGLAIQPQQVVGALKKI------------------ 424

  Fly   473 CPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWF 537
                          |:.|.:      |..|.||..|..:|:|:::|:|:..|.| .::|.||.:.
Zfish   425 --------------NFTLKL------GDIVSFDSTGATVAQYEVVNWQKDANES-IKFKPIGYYD 468

  Fly   538 NGLQ------LNSETVVW-NKETEQPTSACSLPCEVGMIK-KQQG-DTCCWICDSCESFEY--VY 591
            ..|.      |::|.::| ..:.::|.|.||..|..|..| .|:| ..||:.|..|...|.  ..
Zfish   469 ASLPPHQRFVLHTENIIWAGGQLDRPRSVCSESCPPGSRKAAQKGRPVCCYDCIPCAEGEISNQT 533

  Fly   592 DEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPL 656
            |...||.|....|..|:|..|...|::::.:..:..::.:..::||..||:::.:||.:..|||:
Zfish   534 DSNNCKQCPGEYWSNAEKNKCVLKDVEFLSFTEIMGIVLVIFSLFGAVLTALMAILFYRKKDTPI 598

  Fly   657 VRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFH 721
            ::|:..|||:.|||.:::|:..:...|.:||..||:|:....|:.|.:..|.:|.||..:...|.
Zfish   599 IKANNSELSFLLLFSLILCFLCSLTFIGRPTEWSCMLRHTAFGITFVLCISCVLGKTIVVLMAFK 663

  Fly   722 SASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPP----GTRFYYPDRREVILKCKI-Q 781
            :|......:|:..|..|.:...:|..|||||.::|:.:.||    ..::|   :.:::|:|.: .
Zfish   664 AALPGNNIMKWFGPVQQRLSVFALTLIQVLICVLWLTMSPPFPHKNLKYY---QEKIVLECNLGS 725

  Fly   782 DMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEV 846
            ::.|.....|..:|..:|.|.|...||:|:||||:|||.|:|...|.:|:.|:|.|......:.|
Zfish   726 NIGFWAVLGYIGLLAVLCFILAFLARKLPDNFNEAKFITFSMLIFCAVWITFIPAYVSPPGKFTV 790

  Fly   847 QTTTLCISISLSASVALV-CLYSPKVYILVFHPDKNVRKLTMNSTV 891
            ......|   |::|..|: |::.||.||::..|:||.::..|...:
Zfish   791 AVEIFAI---LASSFGLLFCIFVPKCYIILCKPEKNTKQHLMGKVL 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	124/529 (23%)
		NCD3G	556..605	CDD:462210	18/52 (35%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	79/256 (31%)
		TM helix 1	625..650	CDD:320600	6/24 (25%)
		TM helix 2	662..683	CDD:320600	7/20 (35%)
		TM helix 3	692..716	CDD:320600	7/23 (30%)
		TM helix 4	738..758	CDD:320600	8/19 (42%)
		TM helix 5	781..807	CDD:320600	6/25 (24%)
		TM helix 6	815..838	CDD:320600	10/22 (45%)
		TM helix 7	845..870	CDD:320600	6/25 (24%)
LOC100007225	XP_073785873.1	None