Protein Alignment mGluR and olfcg5

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001103413.1
• Gene: olfcg5 / 100004890
• ZFINID: ZDB-GENE-060503-913
• Length: 833
• Species: Danio rerio
• Alignment Length: 884
• Identity: 222/884 - (25%)
• Similarity: 407/884 - (46%)
• Gaps: 131/884 - (14%)

  Fly    43 GDIILGGLFPVH-----------EKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITI 96
            ||:.:||:|.:.           :|.:...|. .|..|..:..:.|::||:.:|...::||.::|
Zfish    38 GDVTIGGIFSIRSVEILPSLEFTQKPQLLSCS-SVNLRDFRMAQIMIFAIEEINRSESLLPNVSI 101

  Fly    97 GVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSG--PVFGVIGGSYSS 159
            |..|.|:|.....:::.::     ||.|         |...|  :.|..:|  |:..:||.:.||
Zfish   102 GYKIYDSCGSRLSSISATM-----SLMN---------DQEFP--KGNICNGQYPIHAIIGETESS 150

  Fly   160 VSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIH 224
            .::.::.....|.||.:|.::|.:.||::..:..|.||:..|..||.||..|:|.|.||:|..::
Zfish   151 ATVILSRTTGPFKIPVISHSATCECLSNRRDYPSFFRTIASDYHQSRALAYIVKYFGWSWVGAVN 215

  Fly   225 SEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDAR 289
            |:..||..|:....|.|.|..:|:..:.|......:|:  ..:.:..|:...:.::.|....:..
Zfish   216 SDNDYGNNGMAIFLKTAQEEGICVEYSVKFYRTEPEKL--QKVVETMKRSTTKIIIAFLSRVEMV 278

  Fly   290 RILQAAKRANLSQPFHWIASDGWGKQQKLL-EGLEDIAEGAITVELQSEIIADFDRYMMQLTPET 353
            .:|:.....|:| .|..|..:.|...:.|: .....|..|::...::......|..|:::
Zfish   279 NLLEELSIQNIS-GFQVIGVEAWTTAKSLITPNSFHILGGSLGFAVRKIDTEGFLDYVIK----- 337

  Fly   354 NQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYR--LSEKVGYEQES 416
                    .:|:..|.|::.:.|                  :.|..| .||:  |..|...|...
Zfish   338 --------SFWDSAFPCLIVNSS------------------QLKVNC-SSYKDLLVLKNDNEDVP 375

  Fly   417 KTQF---VVDAVYAFAYALHNLHN--DRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDM 476
            :.::   |..||||.|::||:|.|  ::...|.:.|.:..:.:::
Zfish   376 EQRYASNVYKAVYAVAHSLHSLLNCKEKKGCQKNLTIQPYQMVEA-------------------- 420

  Fly   477 ANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQ 541
                        |..|:|....|..|.||..|..:|:|:::|:| |::....|:|.:|.:...|.
Zfish   421 ------------LKKVNFTIKFGDRVWFDSTGATIAQYEVVNWQ-QDSDGLIQFKPVGYYDASLP 472

  Fly   542 ------LNSETVVW-NKETEQPTSACSLPCEVGMIK-KQQG-DTCCWICDSCESFEY--VYDEFT 595
                  :.:|.::| ..:.::|.|.||..|..|..| .|:| ..||:.|..|...|.  ..|...
Zfish   473 PDKRFVVKTENIIWAGGKLKKPKSVCSESCPPGTRKAAQKGRPVCCYDCIPCAEGEISNETDSVN 537

  Fly   596 CKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRAS 660
            ||.|....|...:|..|....::::.:..:..::.:..::||:.||.:|.:||....|||:|:|:
Zfish   538 CKQCPLEYWSNTEKNKCVFKSVEFLSFTEVMGVVLVFFSLFGVGLTMLVAILFYNKKDTPIVKAN 602

  Fly   661 GRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASK 725
            ..|||:.|||.:.:|:..:...|.:||..||:|:....|:.|.:..|.:|.||..:...|.:...
Zfish   603 NSELSFLLLFSLTLCFLCSLTFIGRPTEWSCMLRHTTFGITFVLCISCVLGKTIVVLMAFKATLP 667

  Fly   726 SAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPP----GTRFYYPDRREVILKCKIQDMSFL 786
            .:..:|:..|..|.:...:...|||:|.::|:::.||    ..::|   :.::||:|.: ..:..
Zfish   668 GSNIMKWFGPVQQRLSVLAFTLIQVIICVLWLIISPPFPYKNMKYY---KEKIILECSL-GATIC 728

  Fly   787 FSQL--YNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTT 849
            ||.:  |..:|..:|.|.|...||:|:||||:|||.|:|...|.:|:.|:|.|..:...:.|...
Zfish   729 FSAVLFYIGLLAILCFILAFLARKLPDNFNEAKFITFSMLIFCAVWITFIPAYVSSPGKFTVAVE 793

  Fly   850 TLCISISLSASVALV-CLYSPKVYILVFHPDKNVRKLTM 887
            ...|   |::|..|: |::.||.||::|..::|.::..|
Zfish   794 IFAI---LASSFGLLFCIFVPKCYIILFKNEQNTKQHIM 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	116/525 (22%)
		NCD3G	556..605	CDD:462210	18/52 (35%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	80/257 (31%)
		TM helix 1	625..650	CDD:320600	7/24 (29%)
		TM helix 2	662..683	CDD:320600	7/20 (35%)
		TM helix 3	692..716	CDD:320600	7/23 (30%)
		TM helix 4	738..758	CDD:320600	6/19 (32%)
		TM helix 5	781..807	CDD:320600	7/27 (26%)
		TM helix 6	815..838	CDD:320600	10/22 (45%)
		TM helix 7	845..870	CDD:320600	6/25 (24%)
olfcg5	NP_001103413.1	Periplasmic_Binding_Protein_type1	42..486	CDD:471960	115/528 (22%)
		NCD3G	494..547	CDD:462210	18/52 (35%)
		7tmC_V2R_pheromone	568..818	CDD:320410	80/256 (31%)
		TM helix 1	568..592	CDD:320410	7/23 (30%)
		TM helix 2	604..625	CDD:320410	7/20 (35%)
		TM helix 3	634..658	CDD:320410	7/23 (30%)
		TM helix 4	682..698	CDD:320410	4/15 (27%)
		TM helix 5	725..751	CDD:320410	7/25 (28%)
		TM helix 6	759..782	CDD:320410	10/22 (45%)
		TM helix 7	787..812	CDD:320410	6/27 (22%)