DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and olfcg2

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001103759.1	Gene:	olfcg2 / 100004628	ZFINID:	ZDB-GENE-060503-253	Length:	835	Species:	Danio rerio

Alignment Length:	896	Identity:	237/896 - (26%)
Similarity:	407/896 - (45%)	Gaps:	139/896 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SLPGDIILGGLFPVHEKGEGAP------------CGPKVYNRGVQRLEAMLYAIDRVNNDPNILP 92
            |..||:.:||:|.:|.| |..|            |. .|..|..:..:.|::||:.:|...::||
Zfish    32 SKDGDVTIGGVFAIHRK-ETLPSFEFAQKPLPLSCS-SVNLRDFRLAQIMIFAIEEINKSKSLLP 94

  Fly    93 GITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSY 157
            .|.||..|.|||......::.::..:         ||.|    ..|:.|.| ...|:..::|.|.
Zfish    95 NIYIGYRIYDTCGSRLSTMSATMAVL---------SGQE----FRPRDRCN-DQPPLHAILGESE 145

  Fly   158 SSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVST 222
            ||.::.::.....|.:|.:||::|.:.||::..:..|.||:..|..||.||..|:|:|.|::|..
Zfish   146 SSATVILSRTTGPFKVPVISPSATCECLSNRKDYPSFFRTIASDYHQSRALAYIVKHFGWTWVGA 210

  Fly   223 IHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAED 287
            :.|:..||..|:....|.|.|..:|:..:.|......||: ..::::: ||..|:.:|.|....:
Zfish   211 VSSDNDYGNNGMAIFQKIAQEEGICVEYSVKFYRTESDKL-KKVVNEI-KKGTAKVIVAFVSFVE 273

  Fly   288 ARRILQAAKRANLSQPFHWIASDGWGKQQKL--------LEGLEDIAEGAITVELQSEIIADFDR 344
            ...::......|:: .|..|..:.|...:..        |.|....|...|.:|       .|..
Zfish   274 MGLLIDQLSIQNIT-GFQLIGVESWITTKNYFTPNSFSSLRGSLGFAVRKINIE-------GFID 330

  Fly   345 YMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEK 409
            |:::             .:|:..|.|          |....||:...|      .|..|..|.|.
Zfish   331 YVIK-------------AFWDTAFPC----------TKTEGNSSQYSI------SCTRSEDLLEL 366

  Fly   410 VGYEQESKTQ----FVVDAVYAFAYALHNLHNDRCNTQS--DQTTETRKHLQSESVWYRKISTDT 468
            ..|.::...|    .|..||||.|::||:|..  |..|.  |:....|.....|:
Zfish   367 KNYTEDVLEQRYASNVYKAVYAVAHSLHSLLG--CENQGLCDKNKPIRPQQMVEA---------- 419

  Fly   469 KSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVI 533
                                |..|:|....|.:|.||..|..:|.|:::|:| |:....:|:|.:
Zfish   420 --------------------LQKVNFTIQMGDQVWFDSTGGTVAHYEVVNWQ-QDFDGSFQFKTV 463

  Fly   534 GKWFNG-------LQLNSETVVW-NKETEQPTSACSLPCEVGMIK-KQQG-DTCCWICDSCESFE 588
            | :::.       |.||::.::| ..:.::|.|.||..|..|..| .|:| ..||:.|..|...|
Zfish   464 G-YYDASLPPQQRLMLNTKNIIWAGGQQKKPNSVCSESCPPGTRKAAQKGRPVCCYDCIPCAEGE 527

  Fly   589 Y--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKN 651
            .  ..|...||.|....|..|:|..|....::::.:..:..:|.:..::||:.||::|.|||.:.
Zfish   528 ISNETDSINCKQCLEEYWSNAEKNKCVLKAVEFLSFTEIMGIILVFFSLFGVVLTTLVTVLFYRK 592

  Fly   652 HDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRI 716
            .|||:|:|:..|||:.|||.:.:|:..:...|.:||..||:|:....|:.|.:..|.:|.||..:
Zfish   593 KDTPIVKANNSELSFLLLFSLSLCFLCSLTFIGRPTEWSCMLRHTVFGITFVLCISCVLGKTIVV 657

  Fly   717 SRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPD----RREVILK 777
            ...|.:....:..:|:..|..|.:...:...||::|.::|:.:.||   |.|.:    :.::|::
Zfish   658 LMAFKATLPGSNVMKWFGPVQQRLSVLAFTLIQIIICVVWITLSPP---FPYKNMEYYKEKIIIE 719

  Fly   778 CKIQDMSFLFSQL-YNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTG 841
            |.:......::.| |..:|..:|.:.|...||:|:||||:|||.|:|...|.:|:.|:|.|..:.
Zfish   720 CNLGSTLGFWAVLGYISLLSVLCFVLAFLARKLPDNFNEAKFITFSMLIFCAVWITFIPAYVSSP 784

  Fly   842 NSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFHPDKNVRKLTMNSTV 891
            ....|......|   ||:|..|: |:::||.||::..|::|.::..|..|:
Zfish   785 GKLTVAVEIFAI---LSSSFGLLFCIFAPKCYIILLKPEQNTKQHMMGKTL 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	127/531 (24%)
		ANF_receptor	72..518	CDD:279440	108/459 (24%)
		NCD3G	557..604	CDD:284890	17/50 (34%)
		7tm_3	638..873	CDD:278433	75/240 (31%)
olfcg2	NP_001103759.1	PBP1_GPCR_family_C_like	38..480	CDD:153138	126/530 (24%)
		ANF_receptor	74..451	CDD:279440	109/461 (24%)
		NCD3G	495..545	CDD:284890	17/49 (35%)
		7tm_3	589..814	CDD:278433	70/230 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910