DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and olfcq19

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001077346.1	Gene:	olfcq19 / 100003908	ZFINID:	ZDB-GENE-070705-283	Length:	868	Species:	Danio rerio

Alignment Length:	895	Identity:	255/895 - (28%)
Similarity:	419/895 - (46%)	Gaps:	125/895 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPV---------HEKGEGAP--CGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITI 96
            ||:||||||.|         ..|.|..|  | .:......|:.:.|.:|||.:|.:||:||.||:
Zfish    42 GDVILGGLFEVDFLTVFPDLDFKTEPEPPYC-VQFDMESFQQAQTMAFAIDEINKNPNLLPNITL 105

  Fly    97 GVHILDTCSRDTYALNQSLQFVRAS---LNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYS 158
            |.|:.|.|.....|...::.....:   .||::.:|                ..||.|::|.|.|
Zfish   106 GYHLFDNCVMLGMAFRAAISMASGTEEFFNNINCTG----------------PPPVIGIVGDSSS 154

  Fly   159 SVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTI 223
            :||:.::::|.||.:|.||..:|...|||:.::..|.||:|.|.||..|:|.|||.|.|::|..|
Zfish   155 TVSIAISSILGLFRVPIVSHYATCSCLSDRKKYPSFFRTIPSDAFQVRAMVQILKYFRWTWVGLI 219

  Fly   224 HSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFD-SIISKLQKKPNARGVVLFTRAED 287
            :|:..||.|..::..:|......|:|.:|.:|.  |:.:.| ..|:|:.:...||.:|:|:....
Zfish   220 YSDDDYGVYAAQSFQQEMQLFGGCVAFSEVLPH--DNNLEDIKHITKMIQASTARVIVVFSTPSF 282

  Fly   288 ARRILQAAKRANLSQPFHWIASDGWG-----KQQKLLEGLEDIAEGAITVELQSEIIADFDRYMM 347
            ...::......|::.. .||||:.|.     ...:||..|    :|.:.:.::...|.....:::
Zfish   283 LIPLIDELVLQNMTDR-QWIASEAWATSFVHHSPRLLPFL----KGTLGIAIRRGEIQGLYEFLL 342

  Fly   348 QLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRL-SEKVG 411
            :|.|..:.:|.....:||..|.|..       :|....||.|..|.:     |.....| :.|..
Zfish   343 RLQPTNDPKNNMIRIFWEIMFGCNF-------ETGGKKNSGDQVINI-----CTGQEDLRTTKTP 395

  Fly   412 YEQESKTQF---VVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSE------SVWYRKISTD 467
            |.:.|:.:.   |..||||.|:||::|                  :|.|      ||
Zfish   396 YTEVSELRASYNVYKAVYALAHALNDL------------------MQCEDGRGPFSV-------- 434

  Fly   468 TKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKV 532
               .:|.|:.|....:.. :||.||:|....|..|.||:.||.||.||:||:|...:.| .:.:.
Zfish   435 ---NSCADITNLKPWQLV-HYLQNVNFTTDFGDHVSFDKNGDALAIYDVLNWQPSSDGS-IRAQT 494

  Fly   533 IG----KWFNG--LQLNSETVVWNKETEQ-PTSACSLPCEVG-MIKKQQG-DTCCWICDSCESFE 588
            :|    :...|  |.|:.:.:.||.|::: |:|.||..|..| .:...:| ..||:.|..|...|
Zfish   495 VGVVNEEVATGMVLTLDEDALYWNFESKKPPSSVCSESCAPGTRLATIKGLPVCCFDCLPCGDGE 559

  Fly   589 Y--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKN 651
            .  :.....|..|....|...||..|...:::::.:.....:.....::.|.....:|:.:||.:
Zfish   560 ISNITGAVECTMCPDEFWSNLDKDQCIPKEVEFLSYEDPLGISLTTASLLGTCFCVLVMFVFAVH 624

  Fly   652 HDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRI 716
            .:||:|||:..|||:.||..:.:|:......|.:|.:.:|.|:....|:.|.:..|::|.||..:
Zfish   625 RNTPIVRANNSELSFLLLLSLKMCFLCALLFIGQPQLWTCQLRHVVFGISFVLCISSILVKTMVV 689

  Fly   717 SRIFHSA---SKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPG---TRFYYPDRREVI 775
            ..:|.|:   ||.|  :|:.....|......|.||||:|..:|:....|.   ...|.  |.:::
Zfish   690 IAVFKSSRPESKGA--MKWFGAVQQRCTVLVLTAIQVVICAVWLSTASPAPHKNNQYI--RSKIV 750

  Fly   776 LKCKIQDMSFLFSQL--YNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYF 838
            .:|.|..::. ||.|  |..:|..:..:.|...|.:|:||||:|||.|:|...|.:|:||||.|.
Zfish   751 YECAIGSVAG-FSMLLAYIGLLAAVSFLLAFLARNLPDNFNEAKFITFSMLIFCAVWIAFVPAYV 814

  Fly   839 GTGNSYEVQTTTLCISISLSASVA-LVCLYSPKVYILVFHPDKNVRKLTM 887
            .:...|.|......|   |::|.. |:.:::||.||::.||::|.:|..|
Zfish   815 SSPGKYAVAVEIFAI---LASSFGLLLAIFAPKCYIILLHPERNTKKAIM 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	150/534 (28%)
		ANF_receptor	72..518	CDD:279440	130/464 (28%)
		NCD3G	557..604	CDD:284890	13/50 (26%)
		7tm_3	638..873	CDD:278433	75/243 (31%)
olfcq19	NP_001077346.1	Periplasmic_Binding_Protein_Type_1	42..517	CDD:299141	151/541 (28%)
		ANF_receptor	81..483	CDD:279440	132/466 (28%)
		NCD3G	526..577	CDD:284890	13/50 (26%)
		7tm_3	612..847	CDD:278433	75/242 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910