DRSC/TRiP Functional Genomics Resources

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Protein Alignment 4E-T and Eif4enif1

DIOPT Version :9

Sequence 1:NP_726618.3 Gene:4E-T / 43836 FlyBaseID:FBgn0052016 Length:1010 Species:Drosophila melanogaster
Sequence 2:NP_001160019.1 Gene:Eif4enif1 / 74203 MGIID:1921453 Length:983 Species:Mus musculus


Alignment Length:1208 Identity:243/1208 - (20%)
Similarity:398/1208 - (32%) Gaps:457/1208 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDTSKISARYSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKINLNTAALTVSSAYSNQNKN-R 64
            :.|||...||:|.:||.::....|:|||.|.:. :..:.|.|......|:|..:|..|:..:: :
Mouse    20 LPTSKSPHRYTKEELLDIKERPYSKQRPSCLSE-KYDSDGVWDPEKWHASLYPASGRSSPVESLK 83

  Fly    65 LSPEADNSSLICSNSSSISSRRAMRNRERANNYYQRFVPTDSLLISGEDKDKDALSHGQPYKLNI 129
            ...|:|..||:         ||....|||.                 ::.|.|.:...|      
Mouse    84 KESESDRPSLV---------RRIADPRERV-----------------KEDDLDVVLSPQ------ 116

  Fly   130 IDHRSISSS-HLMPAFAKRRFVISKGSNSEESNEGINTCASKGKAASSPSRKGSELDTAETCLNF 193
              .||.... |:..|.:.||    .||..|:.::|:.....                        
Mouse   117 --RRSFGGGCHVTAAVSSRR----SGSPLEKDSDGLRLLGG------------------------ 151

  Fly   194 VQPDHDQCMSSSPTFSTSRQERRIGSGRLLPRSDNWDYKNEKTVEASIENEKETSPNGSGSTSSL 258
                                 |||||||::               ::...||:            
Mouse   152 ---------------------RRIGSGRII---------------SARAFEKD------------ 168

  Fly   259 NQHNQSQHRSRTFSGRLVERVPEVTDRRFQYDSKKSFDRQGINNRRISGKEPFSTQSRSKRGNSY 323
              |..|....|....|         ||...|..|: |.|:..:::|:.|:.        :|.:||
Mouse   169 --HRLSDKDLRDLRDR---------DRERDYKDKR-FRREFGDSKRVFGER--------RRNDSY 213

  Fly   324 LIHEEPEWFSAGPKSQLETIDLHGFED--LEKNEE-RSVTEDKNNQIQQ--LDKNLDAQASKDEA 383
             ..||||||||||.||.|||:|.||:|  ||::.: |..|..:...:::  ::.| ...|.:||.
Mouse   214 -TEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECN-GGVAEEDEV 276

  Fly   384 SMRNSNDSLNFREVIPSDEKKHTDENVVTSIQNSTDLGHPNKNKPIQMQPSQNPESEFNFDAFLN 448
                        |||.:.|.. .|:.|...:                :.|.|:| .||:|:.|.|
Mouse   277 ------------EVILAQEPS-ADQEVPRDV----------------ILPEQSP-GEFDFNEFFN 311

  Fly   449 MH--PLDNSVLSNDETGKSDSKGTSRFSRWFRQKEAA---------------------------- 483
            :.  |...|:: .|..|:. |...|||||||.....:                            
Mouse   312 LDKVPCLASMI-EDVLGEG-SVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAVLSP 374

  Fly   484 ---NNNEF-PGFRESHAQEKRGIPSVKDLE-AQMIKVDMRTDLINPIAGSL-------------- 529
               :.|.| |...|.||:.|     |..|| .|..|||::     |:..||              
Mouse   375 GQNSGNYFAPIPSEDHAENK-----VDILEMLQKAKVDLK-----PLLSSLSANKEKLKESSHSG 429

  Fly   530 -----------CQTVQMEKPIARDTEAFKKLLQQLGSQARQHHPCNDD------CRTINLSNIAN 577
                       .:.:::::.:...|....:.|::..|.|..:.....|      .:.:|....:.
Mouse   430 VVLSVEEVEAGLKGLKVDQQMKNSTPFMAEHLEETLSAASSNRQLKKDGDMTAFNKLVNTMKASG 494

  Fly   578 HVHLESKLHQKINDGHLQQPELSVNVPTMPTSSHVFLQ------KRLEIQHLIQRLHCG-DVSHD 635
            .:..:.|:.:.: :.||..|   ..:|..|.|.::..:      :|....:|:..|... :.:..
Mouse   495 TLPTQPKVSRNV-ESHLLAP---AEIPGQPVSKNILQELLGQPVQRPASSNLLSGLMGSLEATAS 555

  Fly   636 FLEKELDNP------STPAATKDVIATVLNEYSHSK-RNPV--------VTGDPNIFTQQSFLQP 685
            .|.:...:|      .|.||:.|        |.|.: .:|:        :.|||    .|...:|
Mouse   556 LLSQRAPSPPMSQVFRTQAASAD--------YLHPRIPSPIGFPSGPQQLLGDP----FQGMRKP 608

  Fly   686 QSVHQHYSQELHSQNTA------NHTI---------------------------NQLIS------ 711
            .|.......:|..|..|      .|.:                           .|.:|      
Mouse   609 MSPVSAQMSQLELQQAALEGLALPHDLAVQTAPFYQPGFSKPQVDRTRDGLRNRQQRMSKSPAPM 673

  Fly   712 HG---NSPTPLA---------FTPTSVLRKM----TADKDTQSPSTYCQNPQYHVHQQNAKQVGT 760
            ||   :||.|.|         ||||||:|||    ...|:..:|............|:.::    
Mouse   674 HGGNSSSPAPAASITSMLSPSFTPTSVIRKMYESREKTKEEMAPGMVVPGDGKEDTQKTSE---- 734

  Fly   761 RENVLEPQLTATMAVQPRMILGGGNFAIGQNNQHLSPNMSQSRN-------QQVLKWTSGNMQMV 818
             ||:|.......               ..|::...:|.:|..:.       .|..::|  ..|..
Mouse   735 -ENLLSSNPIPN---------------TDQDSSTTNPKLSTLQRSSCSTPLSQTSRYT--KEQDY 781

  Fly   819 HGKTFGR--PILKGGLNSMP--HSNSALPFTAHKIEMQPIHQPHLQQQQHRFKAVQSVESNLNTE 879
            ..||.||  |.|...:...|  .....:|...|...::|.||.|           ..:...|..:
Mouse   782 RPKTAGRKTPTLASPVPGTPFLRPTHQVPLVPHVPIVRPAHQLH-----------PGLVQRLIAQ 835

  Fly   880 SVH----------------------QNITSPVGWHQLYMQHQQQHHHTRQQLSQRVIYGEMHRQS 922
            .||                      |.::.|:....||                .::....|...
Mouse   836 GVHPQHLPSLLQAGVLPPGIDMAPLQGLSGPLLGQPLY----------------PLVSAASHPLL 884

  Fly   923 NPQMSPPV----------------PGFSDSSDSGNVIKANSLTSPS----------YQRDERISS 961
            ||:...|:                ||.|..:.:.:|....::.|.|          ::..:|.||
Mouse   885 NPRPGTPLHLAVMQQQLQRSVLHPPGSSSQAAAISVQTPQNVPSRSGMPHMHSQLEHRTSQRSSS 949

  Fly   962 PTNQLAQWFSPELLAKASAGKLPLLNV-NQALSLEEFE 998
            |.. ||:||..::|.:      ||.:: .:.:|::|.|
Mouse   950 PVG-LAKWFGSDVLQQ------PLPSMPTKVISVDELE 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
4E-TNP_726618.3 EIF4E-T 10..736 CDD:371079 184/875 (21%)
Eif4enif1NP_001160019.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 0/1 (0%)
EIF4E-T 29..710 CDD:371079 183/871 (21%)
YXXXXLphi motif. /evidence=ECO:0000269|PubMed:16343815 29..35 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 40..99 17/68 (25%)
Interaction with CSDE1. /evidence=ECO:0000250|UniProtKB:Q9NRA8 130..160 13/78 (17%)
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q9NRA8 194..210 3/23 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 206..229 14/31 (45%)
Interaction with DDX6. /evidence=ECO:0000250|UniProtKB:Q9NRA8 218..239 16/20 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..360 0/18 (0%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9NRA8 437..446 0/8 (0%)
Interaction with LSM14A. /evidence=ECO:0000250|UniProtKB:Q9NRA8 447..489 5/41 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 585..616 7/34 (21%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:Q9NRA8 612..637 4/24 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 642..693 8/50 (16%)
Interaction with PATL1. /evidence=ECO:0000250|UniProtKB:Q9NRA8 694..712 9/17 (53%)
Atrophin-1 707..>934 CDD:367360 42/275 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..800 18/113 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 906..951 9/44 (20%)
Interaction with LSM14A. /evidence=ECO:0000250|UniProtKB:Q9NRA8 938..983 14/50 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847836
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_28JBG
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006297
OrthoInspector 1 1.000 - - oto93610
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12269
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R7859
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.960

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