Protein Alignment 4E-T and EIF4ENIF1

DIOPT Version :9

• Sequence 1: NP_726618.3
• Gene: 4E-T / 43836
• FlyBaseID: FBgn0052016
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: XP_006724344.3
• Gene: EIF4ENIF1 / 56478
• HGNCID: 16687
• Length: 1027
• Species: Homo sapiens
• Alignment Length: 1193
• Identity: 247/1193 - (20%)
• Similarity: 391/1193 - (32%)
• Gaps: 431/1193 - (36%)

  Fly     4 SKISARYSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKINLNTAALTVSSAYSNQNKN-RLSP 67
            ||...||:|.:||.::....|:|||.|.:. :..:.|.|......|:|..:|..|:..:: :...
Human    65 SKCPHRYTKEELLDIKELPHSKQRPSCLSE-KYDSDGVWDPEKWHASLYPASGRSSPVESLKKEL 128

  Fly    68 EADNSSLICSNSSSISSRRAMRNRERANNYYQRFVPTDSLLISGEDKDKDALSHGQPYKLNIIDH 132
            :.|..||:         ||.:..|||.                 ::.|.|.:...|        .
Human   129 DTDRPSLV---------RRIVDPRERV-----------------KEDDLDVVLSPQ--------R 159

  Fly   133 RSISSS-HLMPAFAKRRFVISKGSNSEESNEGINTCASKGKAASSPSRKGSELDTAETCLNFVQP 196
            ||.... |:..|.:.||    .||..|:.::|:.....
Human   160 RSFGGGCHVTAAVSSRR----SGSPLEKDSDGLRLLGG--------------------------- 193

  Fly   197 DHDQCMSSSPTFSTSRQERRIGSGRLLPRSDNWDYKNEKTVEASIENEKETSPNGSGSTSSLNQH 261
                              |||||||::         :.:|.|                    ..|
Human   194 ------------------RRIGSGRII---------SARTFE--------------------KDH 211

  Fly   262 NQSQHRSRTFSGRLVERVPEVTDRRFQYDSKKSFDRQGINNRRISGKEPFSTQSRSKRGNSYLIH 326
            ..|....|....|  :|..:..|:||:        |:..:::|:.|:.        :|.:|| ..
Human   212 RLSDKDLRDLRDR--DRERDFKDKRFR--------REFGDSKRVFGER--------RRNDSY-TE 257

  Fly   327 EEPEWFSAGPKSQLETIDLHGFED--LEKNEE-RSVTEDKNNQIQQ--LDKNLDAQASKDEASMR 386
            ||||||||||.||.|||:|.||:|  ||::.: |..|..:...:::  ::.| ...|.:||.
Human   258 EEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVKEGIVECN-GGVAEEDEV--- 318

  Fly   387 NSNDSLNFREVIPSDEKKHTDENVVTSIQNSTDLGHPNKNKPIQMQPSQNPESEFNFDAFLNMH- 450
                     |||.:.|.. .|:.|...                .:.|.|:| .:|:|:.|.|:.
Human   319 ---------EVILAQEPA-ADQEVPRD----------------AVLPEQSP-GDFDFNEFFNLDK 356

  Fly   451 -PLDNSVLSNDETGKSDSKGTSRFSRWFRQKEAANNNE----------------------FPGFR 492
             |...|:: .|..|:. |...|||||||.....:.:..                      .||..
Human   357 VPCLASMI-EDVLGEG-SVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAILSPGQN 419

  Fly   493 ----------ESHAQEKRGIPSVKDLE-AQMIKVDMRTDLINPIAGSLCQTVQMEKPIA------ 540
                      |.||:.|     |..|| .|..|||::     |:..||....:..|..:
Human   420 SGNYFAPIPLEDHAENK-----VDILEMLQKAKVDLK-----PLLSSLSANKEKLKESSHSGVVL 474

  Fly   541 --RDTEAFKKLLQQLGSQARQHHPCNDDCRTINLSNIANHVHLESKLHQKINDGHL--------- 594
              .:.||..|.| ::..|.:...|...:.....||.:.|:..|:       .||.:
Human   475 SVEEVEAGLKGL-KVDQQVKNSTPFMAEHLEETLSAVTNNRQLK-------KDGDMTAFNKLVST 531

  Fly   595 --------QQPELSVN----------VPTMPTSSHV----------------------------- 612
                    .||::|.|          :|..|...::
Human   532 MKASGTLPSQPKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSLEPTT 596

  Fly   613 -FLQKRLEIQHLIQRLHCGDVSHDFLEKELDNP--STPAATKDVIATVLNEYSHSKRNPV--VTG 672
             .|.:|.....|.|.......|.|:|...:.:|  .||...:     :|.:.....|.|:  :|.
Human   597 SLLGQRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQ-----LLGDPFQGMRKPMSPITA 656

  Fly   673 D-----------------PN-------IFTQQSFLQPQ-----SVHQHYSQELHSQNTANHTINQ 708
            .                 |:       .|.|..|.:||     ...::..|.:.......|..|
Human   657 QQMSQLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGN- 720

  Fly   709 LISHGNSPTPLA---------FTPTSVLRKMTADKDTQSPSTYCQNPQYHVHQQNAKQVGTRENV 764
                .:||.|.|         ||||||:|||                 |...:::.::..:.:..
Human   721 ----SSSPAPAASITSMLSPSFTPTSVIRKM-----------------YESKEKSKEEPASGKAA 764

  Fly   765 LEPQLTATMAVQPRMILGGGNFAIGQNNQHLSPNMSQSRNQ---------QVLKWTSGNMQMVHG 820
            |......|.......:|...:......:...:.|...|..|         |..::|  ..|....
Human   765 LGDSKEDTQKASEENLLSSSSVPSADRDSSPTTNSKLSALQRSSCSTPLSQANRYT--KEQDYRP 827

  Fly   821 KTFGR--PILKGGLNSMPHSNSA--LPFTAHKIEMQPIHQPH-------LQQQQHRFKAVQSVES 874
            |..||  |.|...:.:.|.....  :|...|...::|.||.|       |.|..|    .|.:.|
Human   828 KATGRKTPTLASPVPTTPFLRPVHQVPLVPHVPMVRPAHQLHPGLVQRMLAQGVH----PQHLPS 888

  Fly   875 NLNT-------ESVH-QNITSPVGWHQLYMQHQQQH-----------H--HTRQQLSQRVIY--- 915
            .|.|       :..| |.|:.|:.....|......|           |  ..:|||.:.|::
Human   889 LLQTGVLPPGMDLSHLQGISGPILGQPFYPLPAASHPLLNPRPGTPLHLAMVQQQLQRSVLHPPG 953

  Fly   916 -----GEMHRQSNPQMSPPVPGFSDSSDSGNVIKANSLTSPSYQRDERISSPTNQLAQWFSPELL 975
                 ..:..|:.||..|        |.||.....:.|   .::..:|.|||.. ||:||..::|
Human   954 SGSHAAAVSVQTTPQNVP--------SRSGLPHMHSQL---EHRPSQRSSSPVG-LAKWFGSDVL 1006

  Fly   976 AKASAGKLPLLNVNQALSLEEFE 998
            .:    .||.:.. :.:|::|.|
Human  1007 QQ----PLPSMPA-KVISVDELE 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
4E-T	NP_726618.3	EIF4E-T	10..736	CDD:371079	182/874 (21%)
EIF4ENIF1	XP_006724344.3	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157426
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JBG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006297
OrthoInspector	1	1.000	-	-		oto90034
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12269
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7859
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.960