Protein Alignment 4E-T and eif4enif1

DIOPT Version :9

• Sequence 1: NP_726618.3
• Gene: 4E-T / 43836
• FlyBaseID: FBgn0052016
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: XP_021332540.1
• Gene: eif4enif1 / 541411
• ZFINID: ZDB-GENE-050320-113
• Length: 944
• Species: Danio rerio
• Alignment Length: 1222
• Identity: 240/1222 - (19%)
• Similarity: 367/1222 - (30%)
• Gaps: 521/1222 - (42%)

  Fly     2 DTSKISA-RYSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKINLNTAALTVSSAYSNQNKNRL 65
            |:...|| ||:|.:|:.::....|.:||:|.:. :..:.|.|
Zfish    16 DSVMTSAYRYTKEELMEIKELPISNERPECLSE-KYDSDGVW----------------------- 56

  Fly    66 SPEADNSSLICSNSSSISSRRAMRNRERANNYYQRFVPTDSLLISGEDKDKDALSHGQPYKLNII 130
            .||..::||..|:.||                    .||:.                  ||.:.:
Zfish    57 DPEKWHASLYPSSESS--------------------CPTEG------------------YKKDYV 83

  Fly   131 DHRSISSSHLMPAFAKRRFVISKGSNSEESNEGINTCASKGKAASSPSRK--GSELDTAETCLNF 193
            |.|       :|  .|||....:....::..|          ...||.|:  |.....|:|.|
Zfish    84 DDR-------VP--LKRRIADPRERVKDDDLE----------VVLSPQRRSFGGGCQVAQTAL-- 127

  Fly   194 VQPDHDQCMSSSPTFSTSRQE---------RRIGSGRLLPRSDNWDYKNEKTVE--ASIENEKET 247
                     ...||.....:|         |||||||::.         .:..|  |.::.|:|
Zfish   128 ---------PRRPTSPLENKENESLRLGGARRIGSGRIMA---------SRVFERDARVDKERE- 173

  Fly   248 SPNGSGSTSSLNQHNQSQHRSRTFSGRLVERVPEVTDRRFQYDSKKSFDRQGINNRRISGKEPFS 312
                             :.|.|.|.           |:||         |:...::|:.
Zfish   174 -----------------RDRERDFK-----------DKRF---------RRDFGDKRVF------ 195

  Fly   313 TQSRSKRGNSYLIHEEPEWFSAGPKSQLETIDLHGFEDLEKNEERSVTEDKNNQIQQLDKNLDAQ 377
              |..:|.:|| ..|||||||.||.||.|||:|.||:|       .:.||        ||....:
Zfish   196 --SERRRNDSY-AEEEPEWFSGGPTSQSETIELIGFDD-------KILED--------DKRRTKR 242

  Fly   378 ASKDEASMR--NSNDSLN-----FREVIPSDEKKHTDENVVTSIQNSTDLGHPNKNKPIQMQPSQ 435
            :.|...|::  ..|..|:     .||.....|..|.:                        .|.|
Zfish   243 SKKRPESVKEVECNGGLSDGPEVVRESGADQEVPHAE------------------------LPEQ 283

  Fly   436 NPESEFNFDAFLNMHPLDNSVLSNDETGKSDSK-GTSRFSRWFRQKEAANNNEFPGFRESHAQEK 499
            .| .:|:|:.|.|:......:.|..|...:|.. ..|||||||      ::|..|.  .|.:...
Zfish   284 TP-GDFDFNEFFNLEKTMPGLASMIEDVLADGPVMASRFSRWF------SSNRSPS--GSRSSSL 339

  Fly   500 RGIPSVKDLEAQMIKVDMRTDLINPIAGSLCQTVQME-KPIARDTEAFK-KLLQQLGSQARQHHP 562
            |..|. ::||        |...::|..|||.|...:. .||:......| .:|:.|       |.
Zfish   340 RSTPH-EELE--------RLAGLDPHTGSLNQGPSLYFTPISSAEHKEKVDILELL-------HK 388

  Fly   563 CNDDCRTINLSNIANHVHLESKLHQKINDGHLQQPELSVNVPTMPTSSHVFLQ--------KRLE 619
            .|.|.:.: ||::            .:|..||::          .|||.|.|.        |.|:
Zfish   389 ANIDLKPL-LSSL------------NVNKAHLKE----------STSSGVVLSLEEVEVGLKGLK 430

  Fly   620 IQ-----HLIQRLHCGDVSHDFLEKELD-----NPSTPAATKDVIATVLNEYSHSKR-------- 666
            :|     .|.||...|.....|:.:.|:     ...|.|..:|...:..|:..::.:
Zfish   431 VQPEPAPSLPQRQSSGGGGTPFMAEHLEEALTGGAKTTARPRDSDMSAFNKLVNTMKASGTLPTL 495

  Fly   667 ------NP-----------------------------VVT--------------GDPNIFTQQSF 682
                  ||                             :||              ..|.:|.|:|.
Zfish   496 PKASGTNPQQQSVDPVLVSLTEAQVPAPQQKNIFQELLVTPHGPVPVPGLIHHRASPPLFPQRSQ 560

  Fly   683 LQ---------------PQSV-------------------------------------------- 688
            :|               ||:|
Zfish   561 MQDFFPGMSPATGFHGGPQTVLDQIPDLHRARNTQPMRALPMGVDQTNLEALFQQDLAVLNRPQY 625

  Fly   689 HQHYSQELHSQNTANHTINQLISHGNSPTP-----------------LAFTPTSVLRKM------ 730
            .|.|:::.|.:...|.....    ..||.|                 .:||||||::||
Zfish   626 QQAYNKQAHDKMFRNRPTRM----NRSPVPHLPGRTSPGSTVTSVLSPSFTPTSVIKKMYESKEK 686

  Fly   731 --------------------------------TADKDTQSPST----YCQNPQYHVHQQNAKQVG 759
                                            ..|.||..|.|    .|..|   |..|| :.:.
Zfish   687 SRDDLGSRPGSKEETVNSHNSQDDGPPSPSSFLEDVDTSGPQTGGVKACSTP---VPTQN-RHIK 747

  Fly   760 TRENVLEPQLTATMAVQPRMILGGGNFAIGQNNQH---LSPNMSQSRNQQVLKWTSGNMQM---- 817
            ..|....|.:|....  |.|:..|.:....:...:   |.|::...|....|.  .|.||.
Zfish   748 DPERPRPPSVTGPHT--PTMLSPGPSSPFPRPQMYPVPLLPHVPLVRPPPQLH--PGVMQRMLAQ 808

  Fly   818 -VHGKTFGRPILKGGLNSMPHSNSALPFTAHKIEMQPIHQPHLQQQQHRFKAVQSVESNLNTESV 881
             :..:..|..:|:.|:.......|.|......:..||::.
Zfish   809 GIQAQQLGPTLLQTGMFPQAVDLSQLQGLPPALLGQPLYP------------------------- 848

  Fly   882 HQNITSPVGWHQLYMQHQQQHHHTRQQLSQRVIYGEMHRQSNPQMSPPVPGFSDSSDSGNVIKAN 946
                .||.| |.|........|   .||:  |:..::.:|..|.:.....|...|...|
Zfish   849 ----LSPAG-HPLMAPRAAGTH---VQLA--VMQQQLQQQQRPNLHVAPSGGPQSQSHG------ 897

  Fly   947 SLTSPSYQRDERISSPTNQLAQWFSPELLAKASAGKLPLLNVNQALSLEEFE 998
                |......|.:||...||:||..::|.:    .||.:...:.:|::|.|
Zfish   898 ----PHRTNQRRGASPPLGLAKWFGSDMLQQ----PLPSMPSTKVISVDELE 941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
4E-T	NP_726618.3	EIF4E-T	10..736	CDD:371079	179/937 (19%)
eif4enif1	XP_021332540.1	EIF4E-T	25..686	CDD:313662	178/899 (20%)
		FtsK	<736..>937	CDD:332908	49/257 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JBG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12269
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7859
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.030