Protein Alignment 4E-T and cup

DIOPT Version :9

• Sequence 1: NP_726618.3
• Gene: 4E-T / 43836
• FlyBaseID: FBgn0052016
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: NP_001285687.1
• Gene: cup / 33934
• FlyBaseID: FBgn0000392
• Length: 1117
• Species: Drosophila melanogaster
• Alignment Length: 933
• Identity: 207/933 - (22%)
• Similarity: 333/933 - (35%)
• Gaps: 258/933 - (27%)

  Fly   128 NIIDHRSISSSHLMPAFAK----------RRFVI------------SKGSNSEESNEGINTCASK 170
            |.:.||| ..|.:||..|.          ||..|            |..:|...:|...|.|
  Fly   341 NALMHRS-KESFVMPRIATCDDIELEGRLRRMNIWRTSDGTRFRTRSTTANLNMNNNNNNEC--- 401

  Fly   171 GKAASSPSRKGSELDTAETCLNFVQPDHDQCMSSSPTFSTSRQERRIGSGRLLPRSDNWDY---- 231
             ..|...::....|.:.|:.:. .||...|.....|...   .:||||||||  ....|.|
  Fly   402 -MPAFFKNKNKPNLISDESIIQ-SQPPQPQTEFQDPAIV---NQRRIGSGRL--NHSKWGYNDED 459

  Fly   232 -------KNEKTVEASIENEKETS-----PNGSGSTSSLNQHNQSQHRSRT-FSGRLVERVPEVT 283
                   |::...|.:.:|.|..:     .||..|       :|.|.|..| ..|..:.|  ...
  Fly   460 YHSYHNGKSQHMEEVNSKNSKNMTVLQFFDNGEIS-------SQPQRRPNTPVMGMSINR--SEN 515

  Fly   284 DRRFQYDSKKSFDRQGIN--NRRISG----KEPFSTQSRSKRGNSYL-IHEEPEWFSAGPKSQLE 341
            |.....:|.:...|...|  .|.:||    .:|.|.....:....|. .:|||||||.||.|:|:
  Fly   516 DTLHSNESSEDLSRANENYVKRVMSGFLVVSKPKSRDVEDRHHRRYRNQNEEPEWFSCGPTSRLD 580

  Fly   342 TIDLHGFEDLEKNEERSVTE-DKNNQIQQLDKNLDAQ---------------ASK--DEASMRNS 388
            ||:|.||::   :||:.:.| :||:.:.:.::....|               .||  .:....|:
  Fly   581 TIELCGFDE---DEEKMLKEGNKNHGLGETERETSKQKMDHKYKWTHAEPMGRSKYMPKHDTNNN 642

  Fly   389 NDSLNFREVIPSDEKKHTDE------------NVVTSIQNSTDLGHPNKNKPIQMQP---SQNPE 438
            ::..|...|:.::.::..:|            ....|.||.....:.|..:|.|.||   .|...
  Fly   643 HNVENMNNVMATEHQQQKEEKRPGSGRSFQFDKFNQSQQNYESSSYVNHQQPPQTQPQQMQQQSN 707

  Fly   439 SEFNFDAFLNMHPLDNSVLSNDETGKSDSKGTSRFSRWFRQKEAANNNEFPGFRESHAQEKRGIP 503
            :..|...|:       |..:|:  |.|.|...:.|.:....:...||.|.|.......|    :|
  Fly   708 TNTNNSKFM-------SFFANE--GNSSSSSLNEFFKQAINQGHGNNPEQPKSLGHIGQ----MP 759

  Fly   504 SVKDLEAQMIKVDMRTDLINPIAGSLCQTVQMEKPIARDTEAFKKLLQQLGSQARQHHPCNDDCR 568
            ||..|||:     .|.:.:|.:.    :|..      :.|:.|:||:..|.|...|       .:
  Fly   760 SVDQLEAK-----WRRNSLNNVG----ETAN------KQTDNFQKLIGSLSSAKPQ-------SQ 802

  Fly   569 TINLSNIANHVHLESKLHQKINDGHL---QQPELSVNVPTMPTSSHVFLQKRLEIQHLIQRLHCG 630
            .:....|:|.:..:.:..|:....||   ||.:.:..:.::...:   :..|.:.|.|:.||..|
  Fly   803 AVGYDAISNFIMQQQQYQQQQQKQHLIIQQQQQHTAFLASLQLKA---ILGRADTQLLLLRLTKG 864

  Fly   631 DVSHDFLEKELDNPSTPAATKDVIATVLNEYSHSKRNPVVTGDPNIFTQQSFLQPQSVHQHYSQE 695
            ::|...|..:|.||......::.|..||                      .|...|...|.:.|:
  Fly   865 EISKHGLLVQLANPRLTDMDREAITAVL----------------------QFTNTQQQQQQHKQQ 907

  Fly   696 LHSQNTANHTI--NQLISHGNSPTPLAFTPTSVLRKMTADKDTQSPSTYCQNPQYHV-HQQNAKQ 757
            |   :..:.|:  :||.:..|         .:::::..|.:  |.|.   .|||... ||.:.:.
  Fly   908 L---DMLSSTVIASQLQNLHN---------LAIVQQTLAAR--QQPQ---HNPQTQAPHQLSQED 955

  Fly   758 VGTRENVLEPQLTATMAVQ---PRMILGGGNFAIGQNNQHLSPNMSQSRNQQVLKWTSGNMQ-MV 818
            :....||:.........::   .::|.||.        :|.:.....:|.||.......|.. ::
  Fly   956 LQAHANVIMRNAVMKRKIEEQTSKLINGGA--------KHQAQQQYLNRGQQRQARPDANSNALL 1012

  Fly   819 HGKTFGRPILKGGLNSMPHSNSALPFTAHKIEMQPIHQPHLQQQQHRF---KAVQSVESNLNTES 880
            |.      ::.||.|:  |: |..|...         ||.......||   :..||.|||
  Fly  1013 HA------LISGGGNN--HA-SGYPMNG---------QPQKHHSNLRFGDNQNFQSFESN----- 1054

  Fly   881 VHQNITSP---VGWHQLYMQHQQQHHHTR-QQLSQRVIYGEMHRQSNPQMSPPVPGFSDSSDSGN 941
                  .|   ..:.|.|.|.||||.|.: |||:      .:|:                :::|.
  Fly  1055 ------QPHFATQYKQQYQQSQQQHPHQQPQQLN------SLHQ----------------NNAGA 1091

  Fly   942 VIKANSLTSPSYQRDERISSPTN 964
            |   ||......|....||...|
  Fly  1092 V---NSFNKAQMQAQSAISMLPN 1111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
4E-T	NP_726618.3	EIF4E-T	10..736	CDD:371079	153/691 (22%)
cup	NP_001285687.1	DUF2477	227..>305	CDD:287586

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12269
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.030