Protein Alignment 4E-T and Eif4enif1

DIOPT Version :10

• Sequence 1: NP_726618.3
• Gene: 4E-T / 43836
• FlyBaseID: FBgn0052016
• Length: 1010
• Species: Drosophila melanogaster
• Sequence 2: XP_006251352.1
• Gene: Eif4enif1 / 305468
• RGDID: 1560908
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 1205
• Identity: 254/1205 - (21%)
• Similarity: 397/1205 - (32%)
• Gaps: 450/1205 - (37%)

  Fly     1 MDTSKISARYSKVDLLALRYEGKSRQRPQCSTRLELQTLGFWKINLNTAALTVSSAYSNQNKN-R 64
            :.|||...||:|.:||.::....|:|||.|.:. :..:.|.|......|:|..:|..|:..:: :
  Rat    40 LPTSKSPHRYTKEELLDIKERPYSKQRPSCLSE-KYDSDGVWDPEKWHASLYPASGRSSPVESLK 103

  Fly    65 LSPEADNSSLICSNSSSISSRRAMRNRERANNYYQRFVPTDSLLISGEDKDKDALSHGQPYKLNI 129
            ..||:|..||:         ||....|||.                 ::.|.|.:...|
  Rat   104 KEPESDRPSLV---------RRIADPRERV-----------------KEDDLDVVLSPQ------ 136

  Fly   130 IDHRSISSS-HLMPAFAKRRFVISKGSNSEESNEGINTCASKGKAASSPSRKGSELDTAETCLNF 193
              .||.... |:..|.:.||    .||..|:.::|:.....
  Rat   137 --RRSFGGGCHVTAAVSSRR----SGSPLEKDSDGLRLLGG------------------------ 171

  Fly   194 VQPDHDQCMSSSPTFSTSRQERRIGSGRLLPRSDNWDYKNEKTVEASIENEKETSPNGSGSTSSL 258
                                 |||||||::               ::...||:
  Rat   172 ---------------------RRIGSGRII---------------SARAFEKD------------ 188

  Fly   259 NQHNQSQHRSRTFSGRLVERVPEVTDRRFQYDSKKSFDRQGINNRRISGKEPFSTQSRSKRGNSY 323
              |..|....|....|         ||...|..|: |.|:..:::|:.|:.        :|.:||
  Rat   189 --HRLSDKDLRDLRDR---------DRERDYKDKR-FRREFGDSKRVFGER--------RRNDSY 233

  Fly   324 LIHEEPEWFSAGPKSQLETIDLHGFED--LEKNEE-RSVTEDKNNQIQQ--LDKNLDAQASKDEA 383
             ..||||||||||.||.|||:|.||:|  ||::.: |..|..:...:::  ::.| ...|.:||.
  Rat   234 -TEEEPEWFSAGPTSQSETIELTGFDDKILEEDHKGRKRTRRRTASVREGIVECN-GGVAEEDEV 296

  Fly   384 SMRNSNDSLNFREVIPSDEKKHTDENVVTSIQNSTDLGHPNKNKPIQMQPSQNPESEFNFDAFLN 448
                        |||.:.|.. .|:.|...:                :.|.|:| .||:|:.|.|
  Rat   297 ------------EVILAQEPS-ADQEVPRDV----------------ILPEQSP-GEFDFNEFFN 331

  Fly   449 MH--PLDNSVLSNDETGKSDSKGTSRFSRWFRQKEAA---------------------------- 483
            :.  |...|:: .|..|:. |...|||||||.....:
  Rat   332 LDKVPCLASMI-EDVLGEG-SVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAVLSP 394

  Fly   484 ---NNNEF-PGFRESHAQEKRGIPSVKDLE-AQMIKVDMRTDLINPIAGSLCQTVQMEKPIA--- 540
               :.|.| |...|.||:.|     |..|| .|..|||::     |:..||....:..|..:
  Rat   395 GQNSGNYFAPIPSEDHAENK-----VDILEMLQKAKVDLK-----PLLSSLSANKEKLKESSHSG 449

  Fly   541 -----RDTEAFKKLLQQLGSQARQHHPCNDDCRTINLSNIANHVHLESKL------HQKINDGHL 594
                 .:.||..|.| ::..|.:...|...:             |||..|      .|...||.:
  Rat   450 VVLSVEEVEAGLKGL-KVDQQIKNSTPFMAE-------------HLEETLSAVTSNRQLKKDGDM 500

  Fly   595 QQPELSVNV----PTMPTSSHVFLQKRLEIQHLI--QRLHCGDVSHDFLEKELDNPSTPAATKDV 653
            ......||.    .|:||...|  .:.|| .||:  ..:....|..:.|::.|..|....|:.::
  Rat   501 TAFNKLVNTMKASGTLPTQPKV--SRNLE-SHLLAPAEIPGQPVPKNILQELLGQPVQRPASSNL 562

  Fly   654 IATVLN-----------------------------EYSHSK-RNPV--------VTGDP------ 674
            ::.::.                             :|.|.: .:|:        :.|||
  Rat   563 LSGLMGSLEPTASLLSQRAPSPPMSQVFRTQAASADYLHPRIPSPIGFPSGPQQLLGDPFQGMRK 627

  Fly   675 --------------------------------NIFTQQSFLQPQSVHQHYSQELHSQNTANHTIN 707
                                            ..|.|..|.:||............|........
  Rat   628 PMSPVTAQMSQLELQQAALEGLTLPHDLAVQTTPFYQPGFSKPQVDRTRDGLRNRQQRMTKSPAP 692

  Fly   708 QLISHGNSPTPLA---------FTPTSVLRKM----TADKDTQSPSTYCQNPQYHVHQQNAKQVG 759
            ....:.:||.|.|         ||||||:|||    ...|:..:|.|.....    .:::| |..
  Rat   693 MHRGNSSSPAPAASITSMLSPSFTPTSVIRKMYESREKSKEEIAPGTVVPGD----GKEDA-QKA 752

  Fly   760 TRENVLEPQLTATMAVQPRMILGGGNFAIGQNNQHLSPNMSQSRN-----------QQVLKWTSG 813
            :.||:|...                  :|..::|..||..:...:           .|..::|
  Rat   753 SEENLLSSN------------------SISNSDQDSSPTANPKLSTLQRSSCSTPLSQTNRYT-- 797

  Fly   814 NMQMVHGKTFGR--PILKGGLNSMP--HSNSALPFTAHKIEMQPIHQPHLQQQQHRFKAVQSVES 874
            ..|....|..||  |.|...:...|  .....:|...|...::|.||.|           ..:..
  Rat   798 KEQDYRPKAAGRKTPTLASPVPGTPFLRPTHQVPLVPHVPIVRPAHQLH-----------PGLVQ 851

  Fly   875 NLNTESVH----------------------QNITSPVGWHQLYMQHQQQHH-----------H-- 904
            .|..:.||                      |.::.|:....||.......|           |
  Rat   852 RLIAQGVHPQHLPGLLQAGVLPPGIDIAPLQGLSGPLLGQPLYPLVSAASHPLLNPRPGTPLHLA 916

  Fly   905 -TRQQLSQRVIY--GEMHRQS--NPQMSPPVPGFSDSSDSGNVIKANSLTSPSYQRDERISSPTN 964
             .:|||.:.|::  |...:.:  |.|..|.||     |.||.....:.|   .::..:|.|||..
  Rat   917 VMQQQLQRSVLHPPGSSSQAAAINVQTPPNVP-----SRSGLPHMHSQL---EHRTSQRSSSPVG 973

  Fly   965 QLAQWFSPELLAKASAGKLPLLNV-NQALSLEEFE 998
             ||:||..::|.:      ||.:: .:.:|::|.|
  Rat   974 -LAKWFGSDVLQQ------PLPSMPTKVISVDELE 1001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
4E-T	NP_726618.3	EIF4E-T	10..736	CDD:371079	187/876 (21%)
Eif4enif1	XP_006251352.1	EIF4E-T	49..730	CDD:371079	186/872 (21%)