Protein Alignment fuss and SKI

DIOPT Version :10

• Sequence 1: NP_001162829.1
• Gene: fuss / 43835
• FlyBaseID: FBgn0039932
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: XP_005244832.1
• Gene: SKI / 6497
• HGNCID: 10896
• Length: 730
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 168/788 - (21%)
• Similarity: 286/788 - (36%)
• Gaps: 242/788 - (30%)

  Fly    26 SQRSNHVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQL 90
            |.||......:|.|..|....:.|::||||.||.|::|:.||..:|:.....|.|.|.:||..||
Human    94 SDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQL 158

  Fly    91 EILRRAGAMPVSSRRCGMITRREAERLCKSFL-GDNTPPRLPDDFA-------------FNVQHK 141
            |||:..|.:|.|:..||:||:.:|||||.:.| |...||....:.|             ..|.|:
Human   159 EILKVMGILPFSAPSCGLITKTDAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHE 223

  Fly   142 CAWGCRGSFLPSRYNSSRAKCIKCSYCGMFFSPNKFIFHSHRITTNDR-YVQPDAANFNSWRRHM 205
            |...|:|..:|..|:|..|.||:|..|.:.:.|:||:.|||:...|.. :...|:||   ||.::
Human   224 CFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSAN---WRAYI 285

  Fly   206 SLS----GNDYDEKIIHAWEDVKAMFNGGTR-KRLV-------GSSINPRSPGSPTQSTAVSSGV 258
            .||    |.:...::....:|||..|:.|.: ||.|       .:||.|::..:.:||.|
Human   286 LLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPA----- 345

  Fly   259 GSSSCGSPTSFERDTNEVDGKSGSSLPQRSQIDSQYNYGTVAAAAAVVGVTAVAAATVGVPFNLH 323
             .|....|:|:.|.......||...:..|.::.:...:....:|
Human   346 -PSEKDKPSSWLRTLAGSSNKSLGCVHPRQRLSAFRPWSPAVSA--------------------- 388

  Fly   324 GSTVLSPLHSLRNERDLSIMPISRNFVVDYMWQQKDQHYQQPYARKIPSGDNSDSSLDFDSWVKP 388
                        :|::||  |.....:.|..:..|                      .|::.|.|
Human   389 ------------SEKELS--PHLPALIRDSFYSYK----------------------SFETAVAP 417

  Fly   389 DSNNPIPNANSVRTSDNCSFNIKNESHSSIYGIIKNHKLSGVPNSGLNLSDYNIPSILNCSAFKP 453
            :.....|....|.:|..|:
Human   418 NVALAPPAQQKVVSSPPCA---------------------------------------------- 436

  Fly   454 VVASTAIVSTSLYTRSNESTRTDCNNPAQSTRTTTVLTHNSISASSHQIVGHKTFSPILGKIHSN 518
                 |.||     |:.|...| |..|.:  |..||.|..:          .:|.:|:     :.
Human   437 -----AAVS-----RAPEPLAT-CTQPRK--RKLTVDTPGA----------PETLAPV-----AA 473

  Fly   519 PEKNRIVSVFASSSTGNADDNDDDDEVVDIETTED-----------EGKFTVQHADS-------- 564
            ||                :|.|.:.| |::|:.|:           ...||...:..
Human   474 PE----------------EDKDSEAE-VEVESREECTFTSSLSSLSSPSFTSSSSAKDLGSPGAR 521

  Fly   565 --PKTQYDAISGSDSPSRSPSTSTNI--DVEQDVDV---------DIITTDTEDQLELSVGRYST 616
              |....||.:.:|:||...:...::  .:|..:|.         :::....:.:.:||....:.
Human   522 ALPSAVPDAAAPADAPSGLEAELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAK 586

  Fly   617 ENTSHSLSFFQ-AEKIQISDLSPNTKTSSGDNETNTLKDAKGINGNLQILARRKRNKLQKDRCLS 680
            .:....|.|.: |:|.::.:.:        :.:.|..|:.:    .|:....:|..:..:.|...
Human   587 RSLHQELEFLRVAKKEKLREAT--------EAKRNLRKEIE----RLRAENEKKMKEANESRLRL 639

  Fly   681 KRTVSKCVSDKSLIKGLAANELSS--SLQIQ------QHVAFPVFLKSQLHS--LRPQQAQQVVS 735
            ||.:.:....:...||..|..|.:  |.||:      ||....   :.||.:  ||.::|::.:.
Human   640 KRELEQARQARVCDKGCEAGRLRAKYSAQIEDLQVKLQHAEAD---REQLRADLLREREAREHLE 701

  Fly   736 LTTNSVAE 743
            .....:.|
Human   702 KVVKELQE 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	DHD_Skor	32..122	CDD:410783	37/89 (42%)
		c-SKI_SMAD_bind	135..228	CDD:198114	32/110 (29%)
SKI	XP_005244832.1	DHD_Ski	91..192	CDD:410786	41/97 (42%)
		c-SKI_SMAD_bind	217..311	CDD:462602	31/96 (32%)
		PTZ00449	<318..478	CDD:185628	46/312 (15%)
		SMC_prok_B	540..>711	CDD:274008	30/185 (16%)