DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fuss and skor1b

DIOPT Version :9

Sequence 1:	NP_001162829.1	Gene:	fuss / 43835	FlyBaseID:	FBgn0039932	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001038598.1	Gene:	skor1b / 567457	ZFINID:	ZDB-GENE-050419-82	Length:	751	Species:	Danio rerio

Alignment Length:	812	Identity:	278/812 - (34%)
Similarity:	372/812 - (45%)	Gaps:	234/812 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSNHVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQLEI 92
            :.|.||...|||:.||||.|:||||||||||||||||.:||||||||||||||||||||||||||
Zfish    32 KPNQVSETSLYGIPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEI 96

  Fly    93 LRRAGAMPVSSRRCGMITRREAERLCKSFLGDNTPPRLPDDFAFNVQHKCAWGCRGSFLPSRYNS 157
            ||||||||:|||||||||:||||||||||||.::||:||::|||:|.|:||||.||:|:|:||||
Zfish    97 LRRAGAMPISSRRCGMITKREAERLCKSFLGAHSPPKLPENFAFDVSHECAWGSRGNFIPARYNS 161

  Fly   158 SRAKCIKCSYCGMFFSPNKFIFHSHRITTNDRYVQPDAANFNSWRRHMSLSGNDYDEKIIHAWED 222
            |||||||||:|.|:|||||||||||| |...:|.|||||||||||||:.||..:..:.:||||||
Zfish   162 SRAKCIKCSFCNMYFSPNKFIFHSHR-TPESKYTQPDAANFNSWRRHLKLSDKNSSDDVIHAWED 225

  Fly   223 VKAMFNGGTRKRLVGSSINPRSPGSP--------------------------TQSTAVSS----G 257
            ||||||||:|||.:....:..||..|                          |..:::.|    .
Zfish   226 VKAMFNGGSRKRTLPIGRSESSPSQPPRGQTQGEPSDVPHKTLRCEDDRVNVTMPSSIRSYPVIP 290

  Fly   258 VGSSSCG-----------SPTSF-------ERDTNEVDGK------SGSSLPQRSQIDSQYN--- 295
            |.|.|.|           .|..|       ::|..||.|:      ||...|  |..||.|.
Zfish   291 VPSKSFGMLQKIPPPLFPHPYGFPAFGLCQKKDDGEVMGEPNKTNLSGVFWP--SPKDSAYTSFP 353

  Fly   296 --YGTVAAAAAVVGVTAVAAATVGVPFNLHG-----STVLSPLHSLRNERDLSIMPISRNFVVDY 353
              :.|..:.|              :|...|.     |.||...|   ||.|:|
Zfish   354 MFWPTTGSLA--------------MPTYHHAQPKPPSDVLCARH---NELDVS------------ 389

  Fly   354 MWQQKDQHYQQPYARKIPSGDNSDSSLDFDSWVKPDSNNPIPNANSVRTSDNCSFNIKNESHSSI 418
              :|.|:....|          .||.||         |....:..|.|..::.|   .:||.|
Zfish   390 --EQSDRSTSTP----------KDSLLD---------NERCSSTQSTRNEEDKS---GDESRS-- 428

  Fly   419 YGIIKNHKLSGVPNSGLNLSDYNIPSILNCSAFKPVVASTAIVSTSLYTRSNESTRTDCNNPAQS 483
                    :.|:|.:...:|        ..|||:|||.....:: .||     ..|...:.|...
Zfish   429 --------IEGIPPTSRKIS--------YISAFRPVVKDVESIA-KLY-----GNRGPYSGPRSG 471

  Fly   484 TRTTTVLTHNSISASSHQIVGHKTFSPILGKIHSNPEKNRIVSVFASSSTGNADDNDDDDEVVDI 548
            ..:...|:.:|         .:::.||                        :.|..||.|  ||:
Zfish   472 YMSPDFLSESS---------SYRSVSP------------------------DVDSVDDPD--VDV 501

  Fly   549 ET---TEDEG--KFTVQHADSPKT----QYDAISGSDSPSRSPST-----STNIDVEQDVDVDII 599
            |:   .|||.  :.:|....||.:    |.:.:.|.|..:....|     |||....:..|::..
Zfish   502 ESHKAHEDEECLQLSVDDRRSPHSLTLAQSEGVKGQDQENTQMHTLNDLHSTNSSETRPSDMESH 566

  Fly   600 TTDTEDQLELSVGRYSTENTSH----SLSFFQA-----EKIQISDLSPNTKTSSGDN-ETNTLKD 654
            ......:.|:    |:.|...|    |.|:|.:     .:..:.|:.....:|:.:. |....:|
Zfish   567 GNKHTTRFEV----YARERDEHVHQMSTSYFGSATTYQRETSVKDVHEEEPSSTVEEMEPKNHQD 627

  Fly   655 AKGINGNLQILARRKRNKLQKDRCLSKRTVSKCVSDK-SL----IKGLAANELSSSLQIQQHV-- 712
            ...|:        .:|.|...|.|..:..:.|...:: ||    |:.:|..||...|..|..:
Zfish   628 ENNIS--------EERLKEPNDVCADEEAICKDTGNRGSLIEKNIESMAKEELQKQLVEQVELRK 684

  Fly   713 -----------AFPVFLKSQLHSLRPQQAQQV 733
                       :|...:|.:| |.|.:..||:
Zfish   685 KLEREFQNLKDSFQDQMKREL-SYREEMVQQL 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	Ski_Sno	25..123	CDD:280577	80/94 (85%)
fuss	NP_001162829.1	c-SKI_SMAD_bind	135..228	CDD:198114	66/92 (72%)
skor1b	NP_001038598.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		Ski_Sno	34..127	CDD:280577	80/92 (87%)
		c-SKI_SMAD_bind	140..230	CDD:285935	64/90 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..267		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..434		17/93 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..569		28/149 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	600..635		5/42 (12%)
		RILP-like	<670..>716	CDD:304877	11/47 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3767
eggNOG	1	0.900	-	-		E1_2C3ZR
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003480
OrthoInspector	1	1.000	-	-		otm25922
orthoMCL	1	0.900	-	-		OOG6_106258
Panther	1	1.100	-	-	O	PTHR10005
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2371
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.770