DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fuss and Skor1

DIOPT Version :9

Sequence 1:	NP_001162829.1	Gene:	fuss / 43835	FlyBaseID:	FBgn0039932	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001363881.1	Gene:	Skor1 / 315748	RGDID:	1307687	Length:	964	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	285/938 - (30%)
Similarity:	365/938 - (38%)	Gaps:	335/938 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSNHVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQLEI 92
            :.|.|....||||.||||.|:||||||||||||||||.:||||||||||||||||||||||||||
  Rat    73 KPNQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEI 137

  Fly    93 LRRAGAMPVSSRRCGMITRREAERLCKSFLGDNTPPRLPDDFAFNVQHKCAWGCRGSFLPSRYNS 157
            ||||||||:|||||||||:||||||||||||::.||:||::|||:|.|:||||.||||:|:||||
  Rat   138 LRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPENFAFDVVHECAWGSRGSFIPARYNS 202

  Fly   158 SRAKCIKCSYCGMFFSPNKFIFHSHRITTNDRYVQPDAANFNSWRRHMSLSGNDYDEKIIHAWED 222
            ||||||||.||.|:|||||||||||| |.:.:|.|||||||||||||:.||.....:::.|||||
  Rat   203 SRAKCIKCGYCSMYFSPNKFIFHSHR-TPDAKYTQPDAANFNSWRRHLKLSDKSATDELSHAWED 266

  Fly   223 VKAMFNGGTRKR----------------------------------------------------- 234
            ||||||||||||
  Rat   267 VKAMFNGGTRKRTFSLQGGGGGGANSGSGGAGKGGAGGGGGPGCGSEMAPGPPPHKSLRCGEDEA 331

  Fly   235 ----------------LVGSSINPRSPGSPTQSTAV---------SSGVG----------SSSCG 264
                            |..::..|..||.|..|..|         |.|.|          ....|
  Rat   332 SGPPGPPPPHPQRALGLAAAANGPAGPGGPGGSAGVRSYPVIPVPSKGFGLLQKLPPPLFPHPYG 396

  Fly   265 SPTSF----ERD-----TNEVDGKSGS-------------------------------------- 282
            .||:|    ::|     ..|..|..|:
  Rat   397 FPTAFGLCPKKDDPVLVAGEPKGGPGTGSGGGAGTAAGAGGPGAGHLPPGAGPGPGGGTMFWGHQ 461

  Fly   283 --------------------------------SLPQRSQIDSQYNYGTVAAAAAVVGVTAVAAAT 315
                                            |||......:|.....||||.|.....|.|||.
  Rat   462 PSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPVPPYPAAQSQAKAVAAAVAAAAAAAAAAAG 526

  Fly   316 VGVPFNLHGSTVLSPLH--SLRNER----DLSIMPISRNFVVDYMWQQKDQHYQQPYARKIPSGD 374
            .|.|.:|.|:   .|..  ||..|.    .||..|:..                          |
  Rat   527 GGGPESLDGA---EPAKEGSLGTEERCPSALSRGPLDE--------------------------D 562

  Fly   375 NSDSSLDFDSWVKPDSNNPI---PNANSVRTSDNCSFN--IKN-ESHSSIYGIIKNHKLSG---- 429
            .:|.:|       |.|..|:   |...:.::|...:|.  :|: ||.:.:||..:....||
  Rat   563 GADEAL-------PPSLAPLAPPPPPPARKSSYVSAFRPVVKDAESIAKLYGSAREAYGSGPARG 620

  Fly   430 -VPNSGLNLSDYNIPSILNCSAFKPVVASTAIVSTSLYTRSNESTRTDCNNPAQSTRTTTVLTHN 493
             ||.:|.. ..|..|..|:..:.....||..:.:........||.|......||..      |..
  Rat   621 PVPGTGTG-GGYVSPDFLSEGSSSYHSASPDVDTADEPEVDVESNRFPDEEGAQED------TEP 678

  Fly   494 SISASSHQIVGHKTFSPILGKIHSNPEKNRIVSVFASSSTGNADDNDDD---------------- 542
            |:.::.....|.:...|              .||.:|.:.|..|..|.|
  Rat   679 SVPSTGGGPDGDQPAGP--------------PSVTSSGADGPTDSADGDSPRPRRRLGPPPAIRS 729

  Fly   543 -------DEVV-DIETTEDEGKFTV---------------------QHADS--------PKTQYD 570
                   |:|| ..|.:...|.:.:                     :|..|        |...|.
  Rat   730 AFGDLVADDVVRRTERSPPNGGYELREPCGPLGGPAAAKVYVPERDEHVKSAAAAAALGPAASYL 794

  Fly   571 AISGSDSPSRSPSTSTNID-------------VEQDVDVDIITTDTEDQLELSV-GRYSTENTSH 621
            ....:..|.:..:.||..|             |.|....:  |...||.|.|.| |....|....
  Rat   795 CTPETHEPDKEDNHSTTADDLETRKSFSDQRSVSQPSPAN--TDRGEDGLTLDVTGTQLVEKDIE 857

  Fly   622 SLSFFQAEKIQISDLSPNTKTSSGDNETNTLKDAKGINGNLQILARRKRNKLQKDRCLSKRTVSK 686
            :|:..:.:|:.:..:....|.   :.|..:|||      |.|...:|:         |:.|  .:
  Rat   858 NLAREELQKLLLEQMELRKKL---EREFQSLKD------NFQDQMKRE---------LAYR--EE 902

  Fly   687 CVSDKSLIKGLAANELSSSLQ----IQQ 710
            .|....:::....|||....:    |||
  Rat   903 MVQQLQIVRDTLCNELDQERKARYAIQQ 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	Ski_Sno	25..123	CDD:280577	80/94 (85%)
fuss	NP_001162829.1	c-SKI_SMAD_bind	135..228	CDD:198114	66/92 (72%)
Skor1	NP_001363881.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..72
		Ski_Sno	75..168	CDD:367087	80/92 (87%)
		c-SKI_SMAD_bind	180..272	CDD:198114	66/92 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..365		6/86 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..452		3/37 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..587		19/97 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..766		31/176 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..842		10/50 (20%)
		CCDC66	<850..934	CDD:373669	20/101 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3704
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003480
OrthoInspector	1	1.000	-	-		otm46163
orthoMCL	1	0.900	-	-		OOG6_106258
Panther	1	1.100	-	-	O	PTHR10005
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2371
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.910