DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fuss and Skor1

DIOPT Version :9

Sequence 1:	NP_001162829.1	Gene:	fuss / 43835	FlyBaseID:	FBgn0039932	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_766034.2	Gene:	Skor1 / 207667	MGIID:	2443473	Length:	964	Species:	Mus musculus

Alignment Length:	981	Identity:	284/981 - (28%)
Similarity:	364/981 - (37%)	Gaps:	382/981 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 RSNHVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQLEI 92
            :.|.|....||||.||||.|:||||||||||||||||.:||||||||||||||||||||||||||
Mouse    73 KPNQVGETSLYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQLEI 137

  Fly    93 LRRAGAMPVSSRRCGMITRREAERLCKSFLGDNTPPRLPDDFAFNVQHKCAWGCRGSFLPSRYNS 157
            ||||||||:|||||||||:||||||||||||::.||:||::|||:|.|:||||.||||:|:||||
Mouse   138 LRRAGAMPISSRRCGMITKREAERLCKSFLGEHKPPKLPENFAFDVVHECAWGSRGSFIPARYNS 202

  Fly   158 SRAKCIKCSYCGMFFSPNKFIFHSHRITTNDRYVQPDAANFNSWRRHMSLSGNDYDEKIIHAWED 222
            ||||||||.||.|:|||||||||||| |.:.:|.|||||||||||||:.||.....:::.|||||
Mouse   203 SRAKCIKCGYCSMYFSPNKFIFHSHR-TPDAKYTQPDAANFNSWRRHLKLSDKSATDELSHAWED 266

  Fly   223 VKAMFNGGTRKR----------------------------------------------------- 234
            ||||||||||||
Mouse   267 VKAMFNGGTRKRTFSLQGGGGGGANSGSGGAGKGGAGGGGGPGCGSEMAPGPPPHKSLRCGEDEA 331

  Fly   235 ----------------LVGSSINPRSPGSPTQSTAVSS--------------------------- 256
                            |..::..|..||.|..|..|.|
Mouse   332 AGPPGPPPPHPQRALGLAAAASGPAGPGGPGGSAGVRSYPVIPVPSKGFGLLQKLPPPLFPHPYG 396

  Fly   257 -----------------------GVGSSSCG---------------------------------S 265
                                   |.|:.|.|                                 .
Mouse   397 FPTAFGLCPKKDDPVLVAGEPKGGPGTGSSGGAGTAAGAGGPGAGHLPPGAGPGPGGGTMFWGHQ 461

  Fly   266 PTSFERDTNEVDGKSGS---------------SLPQRSQIDSQYNYGTVAAAAAVVGVTAVAAAT 315
            |:...:|...|...:.:               |||......:|.....||||.|.....|.|||.
Mouse   462 PSGAAKDAAAVAAAAAAATVYPTFPMFWPAAGSLPVPPYPAAQSQAKAVAAAVAAAAAAAAAAAG 526

  Fly   316 VGVPFNLHGSTVLSPLH--SLRNER----DLSIMPISRNFVVDYMWQQKDQHYQQPYARKIPSGD 374
            .|.|.:|.|:   .|..  ||..|.    .||..|:..                          |
Mouse   527 GGGPESLDGA---EPAKEGSLGTEERCPSALSRGPLDE--------------------------D 562

  Fly   375 NSDSSLDFDSWVKPDSNNPIPNANSVRTSDNCSFNIKNESHSSIYGIIKNHKLSGVPNSGLNLSD 439
            .:|.:|       |.|..|:|..                                 |......|.
Mouse   563 GADEAL-------PPSLGPLPPP---------------------------------PPPPARKSS 587

  Fly   440 YNIPSILNCSAFKPVVASTAIVSTSLYTRSNESTRT-DCNNPAQSTRTTTVLTHNSISASSHQIV 503
            |       .|||:|||.....:: .||..:.|:..: ....|...|.|
Mouse   588 Y-------VSAFRPVVKDAESIA-KLYGSAREAYGSGPARGPVPGTGT----------------- 627

  Fly   504 GHKTFSPILGKIHSNPEKNRIVSVFASSSTGNADDNDDDDE-VVDIETT---EDEGKFTVQHADS 564
                     |..:.:|:   .:|..:||....:.|.|..|| .||:|:.   ::||.     .|.
Mouse   628 ---------GGGYVSPD---FLSEGSSSYHSASPDVDTADEPEVDVESNRFPDEEGA-----QDD 675

  Fly   565 PKTQYDAISG---SDSPSRSPS-TSTNIDVEQD---------------------VDVDIITTDTE 604
            .:.:..:..|   .|.|:..|| ||:..|...|                     ...|::..|..
Mouse   676 TEPRAPSTGGGPDGDQPAGPPSVTSSGADGPTDSADGDSPRPRRRLGPPPAIRSAFGDLVADDVV 740

  Fly   605 DQLELS--------------VGR------YSTENTSH------------SLSFFQAEKIQISDLS 637
            .:.|.|              :|.      |:.|...|            :.|:....:....|..
Mouse   741 RRTERSPPSGGYELREPCGPLGGPGAAKVYAPERDEHVKSTAVAAALGPAASYLCTPETHEPDKE 805

  Fly   638 PNTKTSSGDNET-NTLKDAKGINGNLQILARRKRNKLQKDRCLSKRTVSKCVSDKSL----IKGL 697
            .|..|::.|.|| .:..|.:.::........|..:.|..|           |:...|    |:.|
Mouse   806 DNHSTTADDLETRKSFSDQRSVSQPSPANTDRGEDGLTLD-----------VTGTQLVEKDIENL 859

  Fly   698 AANELSSSLQIQQHVAFPVFLKSQLHSLRP-----------------QQAQQVVSLTTNSVAESN 745
            |..||...|..|..:...  |:.:..||:.                 ||.|.|.....|.:.:..
Mouse   860 AREELQKLLLEQMELRKK--LEREFQSLKDNFQDQMKRELAYREEMVQQLQIVRDTLCNELDQER 922

  Fly   746 KWSYPV 751
            |..|.:
Mouse   923 KARYAI 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	Ski_Sno	25..123	CDD:280577	80/94 (85%)
fuss	NP_001162829.1	c-SKI_SMAD_bind	135..228	CDD:198114	66/92 (72%)
Skor1	NP_766034.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..72
		Ski_Sno	75..168	CDD:280577	80/92 (87%)
		c-SKI_SMAD_bind	180..272	CDD:198114	66/92 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..365		6/86 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..461		4/46 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..587		20/130 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	610..768		33/191 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	794..842		8/47 (17%)
		RILP-like	<843..941	CDD:304877	20/99 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3797
eggNOG	1	0.900	-	-		E1_2C3ZR
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003480
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_106258
Panther	1	1.100	-	-	O	PTHR10005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5040
SonicParanoid	1	1.000	-	-		X2371
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.800