Protein Alignment fuss and ski

DIOPT Version :10

• Sequence 1: NP_001162829.1
• Gene: fuss / 43835
• FlyBaseID: FBgn0039932
• Length: 770
• Species: Drosophila melanogaster
• Sequence 2: XP_004916211.1
• Gene: ski / 100486949
• XenbaseID: XB-GENE-494028
• Length: 719
• Species: Xenopus tropicalis
• Alignment Length: 748
• Identity: 173/748 - (23%)
• Similarity: 273/748 - (36%)
• Gaps: 226/748 - (30%)

  Fly    26 SQRSNHVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQL 90
            |.||......:|.|..|....:.|::||||.||.|::|:.||..:|:.....|.:.|.:||..||
 Frog    77 SDRSTERCETILEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHVYCSRCTADQL 141

  Fly    91 EILRRAGAMPVSSRRCGMITRREAERLCKSFL-GDNTPPRL--PDDF------------AFNVQH 140
            |||:..|.:|.|:..||:||:.:|||||.:.| |.:.|||.  ..||            :|.|.|
 Frog   142 EILKVMGILPFSAPSCGLITKTDAERLCNALLYGGSYPPRCAKKSDFPPGPLELELTESSFRVYH 206

  Fly   141 KCAWGCRGSFLPSRYNSSRAKCIKCSYCGMFFSPNKFIFHSHRITTNDR-YVQPDAANFNSWRRH 204
            :|...|||.|:|..|....|.||:|..|.:.:.|:||:.|||:...|.. :...|:||   ||.:
 Frog   207 ECFGKCRGLFVPELYGHPSAPCIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSAN---WRAY 268

  Fly   205 MSLS-------GNDYDEKIIHAWEDVKAMFNGGTRKRLVGSSINPRSPGSPTQSTAVSSGVGSSS 262
            :.|:       |.:...::....|::|..|:...:.:...:.|:       ::..|.......|.
 Frog   269 ILLARDNPGAGGEEEQARLSRLLEEMKEKFDYSNKYKRKAARIS-------SEPVAKKPKADDSI 326

  Fly   263 CGSPTSFERDTNEVDGKSGSSLPQRSQIDSQYNYGTVAAAAAVVGVTAVAAATVGVPFNLHGSTV 327
            ..||:|.|:|      ||.|
 Frog   327 IHSPSSAEKD------KSSS--------------------------------------------- 340

  Fly   328 LSPLHSLRNERDLSIMPISRNFVVDYMWQQKDQHYQQPYARKIPSGDNSDSSLDFDSWVKPDSNN 392
                 .|||        :|.|        .|:..|..|..|...          |..|      :
 Frog   341 -----WLRN--------LSNN--------NKNTGYVHPRQRLSA----------FRPW------S 368

  Fly   393 PIPNANSVRTSDNCSFNIKNESHSSIYGIIKNHKLSGVPNSGLNLSDYNIPSILNCSAFKPVVAS 457
            |..:||....|.:....|::    |.|    |:|      |..||...|:       |..|.|..
 Frog   369 PAISANDKELSAHLPALIRD----SFY----NYK------SFENLVAPNV-------ALAPPVQQ 412

  Fly   458 TAIVSTSLYTRSNESTRTDCNNPAQS--TRTTTVLTHNSISASSHQIVGHKTFSPILGKIHSNPE 520
            ..|.|.........||::. .:|.||  .|.|..|                   ||..:..:.|.
 Frog   413 KVITSPPCVPAVPRSTQSS-GSPPQSRKRRPTAEL-------------------PIAPEAPAPPA 457

  Fly   521 KNRIVSVFASSSTGNADDNDDDDEVVDIETTEDEGKFT--VQHADSPK-TQYDAISGSDSPSRSP 582
            ..|             ::..:.:..:::|:.| |..||  :....||. |...:.....||....
 Frog   458 PIR-------------EEEKESETEIEVESRE-ECMFTSSLSSLSSPSFTSSSSAKELSSPGMLA 508

  Fly   583 STSTNIDVEQDVDVDIITTDTEDQLE-----LSVGRYSTENTSHSLSFFQAEKIQISDLSPNTKT 642
            .|..|...|.....|..::..|.:||     |..|..|.|.....|  .:..|:::..
 Frog   509 PTVINTSYEVASHSDQHSSGLEAELEHLRQALDSGLDSKEAKEKFL--HEVVKMRVKQ------- 564

  Fly   643 SSGDNETNTLKDAK-GINGNLQILARRKRNKLQKDRCLSKRTVSKCV------SDKSLIKGLAAN 700
               :.:.|....|| .:...|:.|...|:.|| ::...:||.:.|.:      ::|.:.:   ||
 Frog   565 ---EEKLNAALQAKRSLQQELEFLRVAKKEKL-REATEAKRNLRKEIERLRAENEKKMKE---AN 622

  Fly   701 ELSSSLQIQQHVAFPVFLKSQLHSLRPQQAQQV 733
            |  |.|::::.:               :||:|:
 Frog   623 E--SRLRLKREL---------------EQARQI 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	DHD_Skor	32..122	CDD:410783	36/89 (40%)
		c-SKI_SMAD_bind	135..228	CDD:198114	31/100 (31%)
ski	XP_004916211.1	DHD_Ski	74..175	CDD:410786	40/97 (41%)
		c-SKI_SMAD_bind	201..299	CDD:198114	31/100 (31%)
		SMC_prok_B	529..>700	CDD:274008	29/143 (20%)