DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fuss and skor1a

DIOPT Version :9

Sequence 1:	NP_001162829.1	Gene:	fuss / 43835	FlyBaseID:	FBgn0039932	Length:	770	Species:	Drosophila melanogaster
Sequence 2:	NP_001124124.1	Gene:	skor1a / 100170817	ZFINID:	ZDB-GENE-080722-5	Length:	751	Species:	Danio rerio

Alignment Length:	799	Identity:	274/799 - (34%)
Similarity:	378/799 - (47%)	Gaps:	187/799 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TSQRSNHVSSVLLYGVQIVSLHIEGQERLCLAQISNTLLKQFSYNEIHNRRVALGITCVQCTPVQ 89
            :|.:.|.||...||||.||||.|:||||||||||||||||.:|||||||||||||||||||||||
Zfish    31 SSMKPNQVSETALYGVPIVSLVIDGQERLCLAQISNTLLKNYSYNEIHNRRVALGITCVQCTPVQ 95

  Fly    90 LEILRRAGAMPVSSRRCGMITRREAERLCKSFLGDNTPPRLPDDFAFNVQHKCAWGCRGSFLPSR 154
            |||||||||||:|||||||||:||||||||||||.:.||:||::|||:|.|:|||||||:|:|:|
Zfish    96 LEILRRAGAMPISSRRCGMITKREAERLCKSFLGAHNPPKLPENFAFDVSHECAWGCRGNFIPAR 160

  Fly   155 YNSSRAKCIKCSYCGMFFSPNKFIFHSHRITTNDRYVQPDAANFNSWRRHMSLSGNDYDEKIIHA 219
            |||||||||||:||.|:|||||||||||| |...:|.|||||||||||||:.|:.....:.:.||
Zfish   161 YNSSRAKCIKCTYCNMYFSPNKFIFHSHR-TPESKYTQPDAANFNSWRRHLKLTDKSLADDLCHA 224

  Fly   220 WEDVKAMFNGGTRKRL-------VGSSINPRSPGSPTQSTAVSSGVGSSSCGSPTSFERDTNEVD 277
            |||||||||||:|||.       :.|.:.|:|.|:.||:|:             :.....|...|
Zfish   225 WEDVKAMFNGGSRKRAMPGSGSEMSSHLKPQSSGNITQTTS-------------SDIPHKTLRCD 276

  Fly   278 GKSGSSLPQRSQIDSQYNYGTVAAAAAVVGVTAVAAATVGVPFNLHGSTVLSPLHSLRNERDLSI 342
            ...|:    .|..:|..||..:...:...|:..      .:|..:.......|...|..::|..:
Zfish   277 DDRGN----LSLSNSVRNYPVIPVPSKSFGMLQ------KIPPPIFPHPYSFPAFGLCQKKDDGV 331

  Fly   343 MPISRNFVVDYMWQ-QKDQHYQQ-----PYARKIP-------------SGDNSDSSLDFDSWVKP 388
            ...::..|....|. .||..|..     |.|..:|             .|..:::.:   |..:.
Zfish   332 GEQNKTNVPSVFWPGAKDGIYPSFPMFWPTAGSLPLSSYQPKPHADLLGGRQTEAEI---SESER 393

  Fly   389 DSNNPIPNANSVRTSDNCSF--NIKN-------ESHSSIYGIIKNHKLSGVPNSGLNLSDYNIPS 444
            ..|.|   .:|:..|:.||.  :::|       |:.||          .|.|::...||
Zfish   394 GGNTP---RDSLFDSERCSSSQSLRNDEDKSGDEARSS----------EGQPSTPRKLS------ 439

  Fly   445 ILNCSAFKPVVASTAIVSTSLYTRSNESTRTDCNNPAQSTRTTTVLTHNSISASSHQIVGHKTFS 509
              ..|||:|||.....:: .||.          |..|.|......|:.:.:|.||    .:::.|
Zfish   440 --YISAFRPVVKDAESIA-KLYG----------NRDAYSGAHPGHLSPDFVSESS----SYRSAS 487

  Fly   510 PILGKIHSNPEKNRIVSVFASSSTGNADDNDDDDEVVDIET-----TEDEGKFTVQHADSPKTQY 569
            |.                        ||..::.|  ||:||     .|:..:.:|....||..:
Zfish   488 PC------------------------ADSGEEPD--VDVETHRIPDDEESIQLSVDDRQSPVRE- 525

  Fly   570 DAISGSDSPSRSP---------STSTNIDVEQDVDV----DIITTDTEDQLELSVGRYSTENTSH 621
                  |:|:..|         |.|.:.|.:|:..|    |.|..|.          ||.|....
Zfish   526 ------DTPTPQPDDDHQTVTFSDSGSPDHKQNKQVAKKSDAIAYDV----------YSHEKDGA 574

  Fly   622 SL-SFFQAEKIQISDLSPNTKTSSGDNET-NTLKDAKGINGNLQILARRKRNKLQKDRCLSKRTV 684
            || :.......::|..:.:|..|...|.| :..:..|..:..:::   .:.|.:  |..|  |:.
Zfish   575 SLQNTLSCSASKLSRCAQDTNDSHISNSTDDECESQKSCSDQIRV---SRENSI--DAAL--RST 632

  Fly   685 SKCVSDKSLIKGLAANELSSSLQIQQHVAFPVFLKSQLHSLRP-----------------QQAQQ 732
            ....:.:..|:.:|..||..  |:.:.|.....|:.:..||:.                 ||.|.
Zfish   633 DNRFNFEKDIENMAKEELQK--QLLEQVELRKKLEREFQSLKDNFQDQMKRELSYREEMVQQLQI 695

  Fly   733 VVSLTTNSVAESNKWSYPV 751
            |.....|.:.:..|..|.:
Zfish   696 VRDTLCNELDQERKARYAI 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fuss	NP_001162829.1	Ski_Sno	25..123	CDD:280577	82/97 (85%)
fuss	NP_001162829.1	c-SKI_SMAD_bind	135..228	CDD:198114	65/92 (71%)
skor1a	NP_001124124.1	Ski_Sno	36..129	CDD:280577	81/92 (88%)
		c-SKI_SMAD_bind	142..232	CDD:285935	63/90 (70%)
		RILP-like	<648..727	CDD:304877	14/69 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	169	1.000	Domainoid score	I3767
eggNOG	1	0.900	-	-		E1_2C3ZR
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003480
OrthoInspector	1	1.000	-	-		otm25922
orthoMCL	1	0.900	-	-		OOG6_106258
Panther	1	1.100	-	-	O	PTHR10005
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5040
SonicParanoid	1	1.000	-	-		X2371
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.800