DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and PXL1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_013016.4	Gene:	PXL1 / 853965	SGDID:	S000001798	Length:	706	Species:	Saccharomyces cerevisiae

Alignment Length:	503	Identity:	99/503 - (19%)
Similarity:	166/503 - (33%)	Gaps:	139/503 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 PDSTRQKIVELAHSGARPCDI-SRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQ 110
            |..|||:.|..|.|  .|..: |.....|....|.:.|   |:....|..:..|:.|..|.|
Yeast    54 PPITRQRNVSAAPS--VPVTMKSAYTASSKSAYSSVKG---ESDIYPPPVLENSERRSVTPP--- 110

  Fly   111 KIADYKRECPSIFAWEIRDRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQNESVYEKLR 175
            |.:::....||..:..|...  ||:....|..       |..|:|..|.||.|..::
Yeast   111 KNSNFTSSRPSDISRSISRP--SERASQEDPF-------RFERDLDRQAEQYAASRH-------- 158

  Fly   176 MFNGQTGGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQA--------DRDDV--QKRELQFS-V 229
                                        ...||||...||        :::|.  .:||...| :
Yeast   159 ----------------------------TCKSPANKEFQAADNFPFNFEQEDAGNTEREQDLSPI 195

  Fly   230 EVSH--TNSHDSTSDGNSEHNSSGDEDSQMRLRLKRKLQRNRTS--FSNEQIDSLEKEFERTHYP 290
            |.|.  ...:|:.|..||.:.:  |....:..:|.::.|:..:|  :.:|.....|.:.|..::.
Yeast   196 ERSFMMLTQNDTASVVNSMNQT--DNRGVLDQKLGKEQQKEESSIEYESEGQQEDENDIESLNFE 258

  Fly   291 DVFARERLADKIGLPEARIQVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGT--TA 353
                          |:.::|:...|...:....|..:.::.:...:.....|..:|.||.|  ..
Yeast   259 --------------PDPKLQMNLENEPLQDDFPEAKQEEKNTEPKIPEINVTRESNTPSLTMNAL 309

  Fly   354 SSSVATSNN----------STPGIVNSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSS 408
            .|.:...:|          .:||:.:|:..|.:.:...|                .|...:.|||
Yeast   310 DSKIYPDDNFSGLESSKEQKSPGVSSSSTKVEDLSLDGL----------------NEKRLSITSS 358

  Fly   409 ESPPLQPAAPRLPLNSGFNTMYSSIPQPIATMAE---NYNSSLGSMTPSCLQQRDAYPYMFHDPL 470
            |:......|..|           .:.|.||.:.:   :.|:.| .|..:||...|.....|
Yeast   359 ENVETPYTATNL-----------QVEQLIAQLDDVSLSRNAKL-DMNGNCLNAVDRKASRF---- 407

  Fly   471 SLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSSPMPSSNTGVISAG 518
            ...|.|:|.:       ||.......|..:..||:...|..|.::..|
Yeast   408 KKSSAYLSGY-------PSMDIPVTQQTSIVQNSNTNLSRQTILVDKG 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	26/106 (25%)
		COG5576	<253..368	CDD:227863	19/128 (15%)
		Homeobox	269..322	CDD:395001	7/54 (13%)
PXL1	NP_013016.4	LIM1_UF1	556..614	CDD:188783
PXL1	NP_013016.4	LIM	621..672	CDD:259829
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030