DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and MIXL1

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001269331.1	Gene:	MIXL1 / 83881	HGNCID:	13363	Length:	240	Species:	Homo sapiens

Alignment Length:	245	Identity:	69/245 - (28%)
Similarity:	93/245 - (37%)	Gaps:	61/245 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 GGWAWYPSNTTTAHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSE 246
            ||....|.:...|.|..|||.   ..||..:|...||.........|:      ...:...|.:.
Human    26 GGALLPPPSPAAALLPAPPAG---PGPATFAGFLGRDPGPAPPPPASL------GSPAPPKGAAA 81

  Fly   247 HNSSGDEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARI-- 309
            .::|              .:|.|||||.||:..||..|.||.|||:..|||||....|||:||
Human    82 PSAS--------------QRRKRTSFSAEQLQLLELVFRRTRYPDIHLRERLAALTLLPESRIQL 132

  Fly   310 ------QVWFSNRRAKWRREEKMRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIV 368
                  ||||.|||||.||:               ||:       |....:......|:..||..
Human   133 LFSPLFQVWFQNRRAKSRRQ---------------SGK-------SFQPLARPEIILNHCAPGTE 175

  Fly   369 NSAINVAERTSSALVSNSLPEASNGPTVLGGEANTTHTSSESPPLQPAAP 418
            ...:.  .:....:..|.|||    |..:||  ..:.:||:....:..:|
Human   176 TKCLK--PQLPLEVDVNCLPE----PNGVGG--GISDSSSQGQNFETCSP 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645
		COG5576	<253..368	CDD:227863	43/122 (35%)
		Homeobox	269..322	CDD:395001	34/60 (57%)
MIXL1	NP_001269331.1	Homeobox	89..150	CDD:278475	34/60 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810