DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment toy and Sdcbp

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_114192.1	Gene:	Sdcbp / 83841	RGDID:	621497	Length:	300	Species:	Rattus norvegicus

Alignment Length:	288	Identity:	56/288 - (19%)
Similarity:	100/288 - (34%)	Gaps:	68/288 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 DRLLSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTT 193
            |:::..|..:|.|..|.:....|:       :..|.....::|.||            ||..:..
  Rat    13 DKVIQAQTASSANPASQAFFLNVV-------DSAAFPPGGNLYPKL------------YPELSQY 58

  Fly   194 AHLTLPPAASVVTSPANLSGQADRDDVQKRELQFSVEVSHTNSHDS------TSDGNSEHNSSGD 252
            ..|:|..|......|. :||...:..:..|....:..|:....:|:      ...|..|.....|
  Rat    59 MGLSLSEAEICENMPV-VSGAPTQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKD 122

  Fly   253 EDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQV------ 311
            :|.::.||||        |..|    .:..:..:.:.|......|..|::      :|:
  Rat   123 QDGKIGLRLK--------SVDN----GIFVQLVQANSPASLVGLRFGDQV------LQINGENCA 169

  Fly   312 -WFSNRRAKWRRE---EK--MRTQRRSADTVDGSGRTSTANNPSGTTASSSVATSNNSTPGIVNS 370
             |.|::..|..::   ||  |..:.|..:      ||.|.:..|    |..|.....|  |.:.|
  Rat   170 GWSSDKAHKVLKQAFGEKITMTIRDRPFE------RTVTMHKDS----SGHVGFIFKS--GKITS 222

  Fly   371 AINVAERTSSALVSNSLPEASNGPTVLG 398
            .:..:....:.|:::......||..|:|
  Rat   223 IVKDSSAARNGLLTDHHICEINGQNVIG 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	6/23 (26%)
		COG5576	<253..368	CDD:227863	26/126 (21%)
		Homeobox	269..322	CDD:395001	9/59 (15%)
Sdcbp	NP_114192.1	Interaction with PDCD6IP. /evidence=ECO:0000250\|UniProtKB:O08992	2..104		21/110 (19%)
		LYPX(n)L motif 1. /evidence=ECO:0000250\|UniProtKB:O08992	3..7
		LYPX(n)L motif 2. /evidence=ECO:0000250\|UniProtKB:O08992	47..51		1/3 (33%)
		LYPX(n)L motif 3. /evidence=ECO:0000250\|UniProtKB:O08992	51..55		3/15 (20%)
		PDZ_signaling	114..193	CDD:238492	19/96 (20%)
		PDZ_signaling	198..271	CDD:238492	14/65 (22%)
		phosphatidylinositol-4, 5-bisphosphate-binding. /evidence=ECO:0000250\|UniProtKB:O00560	252..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900