DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment toy and Pax8

DIOPT Version :9

Sequence 1:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_112403.2	Gene:	Pax8 / 81819	RGDID:	620434	Length:	457	Species:	Rattus norvegicus

Alignment Length:	534	Identity:	181/534 - (33%)
Similarity:	251/534 - (47%)	Gaps:	137/534 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 PHSSVGQSTLFGCSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGC 77
            ||:|:         .:||.|:|||||.:|||||||:..||:||:|||.|.|||||||.|:||:||
  Rat     2 PHNSI---------RSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGC 57

  Fly    78 VSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRLLSEQVCNSDNI 142
            ||||||||||||||:|..||||||:|||..||:||.||||:.|::||||||||||:|.||::|.:
  Rat    58 VSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTV 122

  Fly   143 PSVSSINRVLRNLASQKEQQAQQQNESVYEKLRMFNGQTGGWAWYPSNTTTAHLTLPPA-----A 202
            ||||||||::|.    |.||.             ||        .|.::..|..:|.|.     :
  Rat   123 PSVSSINRIIRT----KVQQP-------------FN--------LPMDSCVATKSLSPGHTLIPS 162

  Fly   203 SVVTSPAN--------------LSGQADRDDVQKRELQFSVEVSHTNSHDSTSDGNSEHNSSGDE 253
            |.||.|.:              |.|.|......||::..|.:.|...|.||.|      :|||
  Rat   163 SAVTPPESPQSDSLGSTYSINGLLGIAQPGSDNKRKMDDSDQDSCRLSIDSQS------SSSG-- 219

  Fly   254 DSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQVWFSNRRA 318
                    .||..|..| |....::.||..|||.|||:.:|..                     :
  Rat   220 --------PRKHLRTDT-FGQHHLEPLECPFERQHYPEAYASP---------------------S 254

  Fly   319 KWRREEKMRTQRRSADTV-DGSGRTSTANNPSGTTASSS-----VA---------------TSNN 362
            ..:.|:.:........|: ||....:.:|.|.|...|:.     ||               :|::
  Rat   255 HTKGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVADPHSPYAIKQETPELSSSS 319

  Fly   363 STPGIVNSA--INVAERTSSALVSNSLP---EASNGPTVLG---GEANTTHTSSESPPLQPAAPR 419
            |||..::|:  :::.:..|......|:|   ..|:..:|.|   |:|..:......|.|....|.
  Rat   320 STPSSLSSSAFLDLQQVGSGGPAGASVPPFNAFSHAASVYGQFTGQALLSGREMVGPTLPGYPPH 384

  Fly   420 LPLNSGFNTMYSSIPQPIATMAENYNSSLGSMTPSCLQQRDAYPYMFHDPLS--LGSPYVSAHHR 482
            :|.:...:...|:|...:|  ...|:.:..|.||..     :|...:..|.|  |.|||    :.
  Rat   385 IPTSGQGSYASSAIAGMVA--GSEYSGNAYSHTPYA-----SYSEAWRFPNSSLLSSPY----YY 438

  Fly   483 NTACNPSAAHQQPP 496
            ::...|||    ||
  Rat   439 SSTTRPSA----PP 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
toy	NP_001368990.1	PAX	29..153	CDD:128645	90/123 (73%)
		COG5576	<253..368	CDD:227863	28/135 (21%)
		Homeobox	269..322	CDD:395001	11/52 (21%)
Pax8	NP_112403.2	PAX	9..133	CDD:128645	90/123 (73%)
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	12..68		42/55 (76%)
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	87..135		32/51 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..226		20/82 (24%)
		Pax2_C	344..455	CDD:289189	30/120 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910